DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CTCF and ZNF544

DIOPT Version :9

Sequence 1:	NP_648109.1	Gene:	CTCF / 38817	FlyBaseID:	FBgn0035769	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	NP_001374339.1	Gene:	ZNF544 / 27300	HGNCID:	16759	Length:	769	Species:	Homo sapiens

Alignment Length:	350	Identity:	118/350 - (33%)
Similarity:	165/350 - (47%)	Gaps:	52/350 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   288 NASGHKYSCPHCPYTASKKFLITRHSRSHDVEPSFKCSICERSFRSNVGLQNHINTHMGNKPHKC 352
            |..|..:||  |.       ||  |.|:|..|..|:|:.|.:||..:..|..|..||.|.||::|
Human   411 NQCGKSFSC--CK-------LI--HQRTHTGEKPFECTQCGKSFSQSYDLVIHQRTHTGEKPYEC 464

  Fly   353 KLCESAFTTSGELVRHTRYKHTKEKPHKCTECTYASVELTKLRRHMTCHTGERPYQCPHC----- 412
            .||..:||...:|:.|.|. ||.|||::|.||..:....:.|..|...||||:||:|.||
Human   465 DLCGKSFTQRSKLITHQRI-HTGEKPYQCIECRKSFRWNSNLIVHQRIHTGEKPYECTHCGKSFS 528

  Fly   413 ----------TYASQDMFK-------------LKRHMVIHTGEKKYQCDICKSRFTQSNSLKAHK 454
                      |:..:..||             |..|...|||||.|:|::|...|:||:.|..|:
Human   529 QSYELVTHKRTHTGEKPFKCTQCGKSFSQKYDLVVHQRTHTGEKPYECNLCGKSFSQSSKLITHQ 593

  Fly   455 LIHSVVDKPVFQCNYCPTTCGRKADLRVHIKHMHTSDVPMTCRRCGQQLPDRYQYKLHVKSHEGE 519
            .||: .:|| :||..|..:....::|.:| :.:||.:.|..|..||:.....||...|.::|.||
Human   594 RIHT-GEKP-YQCIECGKSFRWNSNLVIH-QRIHTGEKPYDCTHCGKSFSQSYQLVAHKRTHTGE 655

  Fly   520 KCYSCKLCSYASVTQRHLASHMLIHLDEKPFHCDQCPQAFRQRQLLRRHMNLVHNEEYQPPEPRE 584
            |.|.|..|..|......|..|:.||..|||:.|:||.:||.:...|..|         |.....|
Human   656 KPYECNECGKAFNRSTQLIRHLQIHTGEKPYKCNQCNKAFARSSYLVMH---------QRTHTGE 711

  Fly   585 KLHKCPSCPREFTHKGNLMRHMETH 609
            |..:|..|.:.|:...||:.|...|
Human   712 KPFECSQCGKAFSGSSNLLSHHRIH 736

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CTCF	NP_648109.1	23ISL	<116..206	CDD:293226
		C2H2 Zn finger	296..316	CDD:275368	6/19 (32%)
		COG5048	321..>621	CDD:227381	106/316 (34%)
		zf-C2H2	322..344	CDD:278523	7/21 (33%)
		C2H2 Zn finger	324..344	CDD:275368	6/19 (32%)
		zf-H2C2_2	337..361	CDD:290200	11/23 (48%)
		C2H2 Zn finger	352..373	CDD:275368	8/20 (40%)
		C2H2 Zn finger	381..401	CDD:275368	5/19 (26%)
		zf-H2C2_2	394..415	CDD:290200	12/35 (34%)
		C2H2 Zn finger	409..429	CDD:275368	8/47 (17%)
		zf-H2C2_2	422..446	CDD:290200	11/23 (48%)
		C2H2 Zn finger	437..457	CDD:275368	7/19 (37%)
		C2H2 Zn finger	467..485	CDD:275368	4/17 (24%)
		C2H2 Zn finger	496..516	CDD:275370	6/19 (32%)
		C2H2 Zn finger	524..544	CDD:275368	5/19 (26%)
		zf-H2C2_2	536..561	CDD:290200	12/24 (50%)
		C2H2 Zn finger	552..573	CDD:275368	7/20 (35%)
		zf-C2H2	587..609	CDD:278523	6/21 (29%)
		C2H2 Zn finger	589..609	CDD:275368	6/19 (32%)
ZNF544	NP_001374339.1	KRAB	68..127	CDD:214630
		C2H2 Zn finger	410..428	CDD:275368	9/27 (33%)
		zf-H2C2_2	424..445	CDD:404364	9/20 (45%)
		C2H2 Zn finger	436..456	CDD:275368	6/19 (32%)
		COG5048	460..>753	CDD:227381	96/289 (33%)
		C2H2 Zn finger	464..484	CDD:275368	8/20 (40%)
		C2H2 Zn finger	492..512	CDD:275368	5/19 (26%)
		C2H2 Zn finger	520..540	CDD:275368	3/19 (16%)
		C2H2 Zn finger	548..568	CDD:275368	2/19 (11%)
		C2H2 Zn finger	576..596	CDD:275368	7/19 (37%)
		C2H2 Zn finger	604..624	CDD:275368	4/20 (20%)
		C2H2 Zn finger	632..652	CDD:275368	6/19 (32%)
		C2H2 Zn finger	660..680	CDD:275368	5/19 (26%)
		C2H2 Zn finger	688..708	CDD:275368	8/28 (29%)
		C2H2 Zn finger	716..736	CDD:275368	6/19 (32%)
		C2H2 Zn finger	744..764	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910