Protein Alignment CTCF and ZNF473

DIOPT Version :10

• Sequence 1: NP_648109.1
• Gene: CTCF / 38817
• FlyBaseID: FBgn0035769
• Length: 818
• Species: Drosophila melanogaster
• Sequence 2: NP_056243.1
• Gene: ZNF473 / 25888
• HGNCID: 23239
• Length: 871
• Species: Homo sapiens
• Alignment Length: 411
• Identity: 115/411 - (27%)
• Similarity: 159/411 - (38%)
• Gaps: 94/411 - (22%)

  Fly   282 STSQNSNASGHK--------YSCPHCPYTASKKFLITRHSRSHDV-------------------- 318
            |.|:.|:...|:        |||..|..|.|....:.:|.:.|.|
Human   467 SFSRPSHLMRHQAIHTAEKPYSCAECKETFSDNNRLVQHQKMHTVKTPYECQECGERFICGSTLK 531

  Fly   319 ---------------------------EPSFKCSICERSFRSNVGLQNHINTH-MGNKPHKCKLC 355
                                       |..|||:.||::|..:..|..|...| .|.||.:|..|
Human   532 CHESVHAREKQGFFVSGKILDQNPEQKEKCFKCNKCEKTFSCSKYLTQHERIHTRGVKPFECDQC 596

  Fly   356 ESAFTTSGELVRHTR-------YK-------------------HTKEKPHKCTECTYASVELTKL 394
            ..||..|..|:.|.|       ||                   ||||.|.||.||.........|
Human   597 GKAFGQSTRLIHHQRIHSRVRLYKWGEQGKAISSASLIKLQSFHTKEHPFKCNECGKTFSHSAHL 661

  Fly   395 RRHMTCHTGERPYQCPHCTYASQDMFKLKRHMVIHTGEKKYQCDICKSRFTQSNSLKAHKLIHSV 459
            .:|...|.||.|::|..|.........|.:|...|..:|...|:.|...|.||:.|..|:.|||
Human   662 SKHQLIHAGENPFKCSKCDRVFTQRNYLVQHERTHARKKPLVCNECGKTFRQSSCLSKHQRIHS- 725

  Fly   460 VDKPVFQCNYCPTTCGRKADLRVHIKHMHTSDVPMTCRRCGQQLPDRYQYKLHVKSHEGEKCYSC 524
            .:|| :.|:||....|..|:|..| :.:||.:.|..|:.||:.........:|.:.|.|||.|.|
Human   726 GEKP-YVCDYCGKAFGLSAELVRH-QRIHTGEKPYVCQECGKAFTQSSCLSIHRRVHTGEKPYRC 788

  Fly   525 KLCSYASVTQRHLASHMLIHLDEKPFHCDQCPQAFRQRQLLRRHMNLVHNEEYQPPEPREKLHKC 589
            ..|..|...:.:|..|..||..|||:.|:.|.:||.....|.:|:. ||.:        |.|::|
Human   789 GECGKAFAQKANLTQHQRIHTGEKPYSCNVCGKAFVLSAHLNQHLR-VHTQ--------ETLYQC 844

  Fly   590 PSCPREFTHKGNLMRHMETHD 610
            ..|.:.|....:|.||...|:
Human   845 QRCQKAFRCHSSLSRHQRVHN 865

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CTCF	NP_648109.1	FAP	116..>202	CDD:429334
		C2H2 Zn finger	296..316	CDD:275368	5/19 (26%)
		COG5048	321..>621	CDD:227381	101/317 (32%)
		C2H2 Zn finger	324..344	CDD:275368	6/19 (32%)
		C2H2 Zn finger	352..373	CDD:275368	10/46 (22%)
		C2H2 Zn finger	381..401	CDD:275368	5/19 (26%)
		zf-H2C2_2	394..415	CDD:463886	8/20 (40%)
		C2H2 Zn finger	409..429	CDD:275368	4/19 (21%)
		zf-H2C2_2	422..446	CDD:463886	7/23 (30%)
		C2H2 Zn finger	437..457	CDD:275368	7/19 (37%)
		C2H2 Zn finger	467..485	CDD:275368	7/17 (41%)
		C2H2 Zn finger	496..516	CDD:275370	4/19 (21%)
		C2H2 Zn finger	524..544	CDD:275368	5/19 (26%)
		zf-H2C2_2	536..561	CDD:463886	11/24 (46%)
		C2H2 Zn finger	552..573	CDD:275368	6/20 (30%)
		zf-C2H2	587..609	CDD:395048	6/21 (29%)
		C2H2 Zn finger	589..609	CDD:275368	6/19 (32%)
ZNF473	NP_056243.1	KRAB_A-box	6..45	CDD:143639
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	47..81
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	140..164
		COG5048	207..614	CDD:227381	34/146 (23%)
		C2H2 Zn finger	211..231	CDD:275368
		C2H2 Zn finger	239..259	CDD:275368
		C2H2 Zn finger	267..286	CDD:275368
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	290..318
		Interaction with SLBP/pre-mRNA complex	312..552		13/84 (15%)
		C2H2 Zn finger	322..342	CDD:275368
		C2H2 Zn finger	349..369	CDD:275368
		C2H2 Zn finger	377..397	CDD:275368
		C2H2 Zn finger	405..425	CDD:275368
		C2H2 Zn finger	433..453	CDD:275368
		COG5048	457..860	CDD:227381	112/404 (28%)
		C2H2 Zn finger	461..481	CDD:275368	4/13 (31%)
		C2H2 Zn finger	489..509	CDD:275368	5/19 (26%)
		C2H2 Zn finger	517..537	CDD:275368	0/19 (0%)
		C2H2 Zn finger	564..584	CDD:275368	6/19 (32%)
		C2H2 Zn finger	593..613	CDD:275368	8/19 (42%)
		C2H2 Zn finger	648..668	CDD:275368	5/19 (26%)
		C2H2 Zn finger	676..696	CDD:275368	4/19 (21%)
		C2H2 Zn finger	704..724	CDD:275368	7/19 (37%)
		C2H2 Zn finger	732..752	CDD:275368	7/20 (35%)
		C2H2 Zn finger	760..780	CDD:275368	4/19 (21%)
		C2H2 Zn finger	788..808	CDD:275368	5/19 (26%)
		C2H2 Zn finger	816..836	CDD:275368	6/20 (30%)
		C2H2 Zn finger	844..864	CDD:275368	6/19 (32%)