DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CTCF and Zfp180

DIOPT Version :9

Sequence 1:	NP_648109.1	Gene:	CTCF / 38817	FlyBaseID:	FBgn0035769	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	NP_653358.2	Gene:	Zfp180 / 246279	RGDID:	631380	Length:	727	Species:	Rattus norvegicus

Alignment Length:	710	Identity:	174/710 - (24%)
Similarity:	270/710 - (38%)	Gaps:	172/710 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 DEDPEDLQTFLNNFHK------EIEG------------NSDEKVVNTILEAISAEAIDLDENG-- 52
            ||.||.||..:.||..      |:||            ::|.|:|          .:||.|.|
  Rat    83 DESPETLQACVENFVLPQEMIIEVEGEDAGSLDILPQESTDFKIV----------TVDLTEEGQS 137

  Fly    53 ----AEAGGSKPMEEA--EADLDHAEEAEEEEEDDEDKYFIDDE-----------------GNCY 94
                |:....:|:..|  ..||..:......||....:...|:|                 .:|.
  Rat   138 TWSKAQRTPERPVTLAGPGRDLWDSTAVHRTEETTSKQTVFDEEPSHGSKPEVLARDDPWLSSCE 202

  Fly    95 IKTTPKKQKELQKKLKQAAAKPGKAT-------RSVVSTATNKSINLRPAKSTPKATTSKPPPEP 152
            .:...::.|:.:..|.|.:|.|.:..       ||.:|| :..|..:.|.::    ...|.....
  Rat   203 EQLEKQQDKQEEGVLTQGSAGPPETVYGDPGFDRSCLST-SRPSFPMIPLRN----HFHKQASHV 262

  Fly   153 KAISVRPARA--------------AAAKAKQSAMPPPPALVVKVPAPRGRP------RKNPVIPK 197
            |.:....|.:              .:.|..||..|     ...:..|:|:.      |..| ..:
  Rat   263 KKLHGDVANSHQQINNNADFFEDDKSGKVPQSLHP-----TQCIRTPKGKKACEFNGRVQP-FGQ 321

  Fly   198 PEPMDLERELEELVDEPDISSMVTELSDYTVDEAAVEAATATLTPNEAEVYEFEDNATTEDENAD 262
            ..|::|.:::.                                  .|.:.:.|:......:.|
  Rat   322 GVPLNLNQKVH----------------------------------LEGKSFGFKGRGQVLNRN-- 350

  Fly   263 KKDVDFVLSNKEVKL----------KTASSTSQNSNASGH----KYSCPHCPYTASKKFLITRHS 313
                  ::.|::.||          |||.|.|...|...:    ::.|.:|..:.|....:..|.
  Rat   351 ------IVLNEQQKLLIKEGQYKCSKTAPSPSLPQNLRNYSEEKRFECKYCGKSFSWSSHLIAHQ 409

  Fly   314 RSHDVEPSFKCSICERSFRSNVGLQNHINTHMGNKPHKCKLCESAFTTSGELVRHTRYKHTKEKP 378
            |:|..|..:||::|.:.|..:..:.:|...|.|.||::|.||..:||....||.|.| .||.|:|
  Rat   410 RTHTGEKPYKCNLCGKFFTRSSHVVSHQRIHTGEKPYRCNLCGKSFTQRYVLVVHQR-THTGERP 473

  Fly   379 HKCTECTYASVELTKLRRHMTCHTGERPYQCPHCTYASQDMFKLKRHMVIHTGEKKYQCDICKSR 443
            ::|.:|..:..:..||..|...||||:||:|..|..:....:||..|..||:|||.|:|..|...
  Rat   474 YECNQCGKSFRQSYKLIAHQRTHTGEKPYECTQCGKSFIQSYKLIAHQKIHSGEKPYECSHCGKS 538

  Fly   444 FTQSNSLKAHKLIHSVVDKPVFQCNYCPTTCGRKADLRVHIKHMHTSDVPMTCRRCGQQLPDRYQ 508
            |:||..|.||:..|: .:|| |:||||..:....:.|..| :..||.:.|..|..||:.......
  Rat   539 FSQSYKLVAHQRTHT-GEKP-FECNYCGKSFSWSSQLVSH-QRTHTGEKPYECNECGKSFNRSSH 600

  Fly   509 YKLHVKSHEGEKCYSCKLCSYASVTQRHLASHMLIHLDEKPFHCDQCPQAFRQRQLLRRHMNLVH 573
            ..:|.::|.|||.|.||.|..:......|..|...|..|||:.|.||.:.|||.....:|.. .|
  Rat   601 LVMHQRTHTGEKPYQCKQCGKSFSQSYVLVVHQRTHTGEKPYECGQCGKTFRQSSCFTQHQR-TH 664

  Fly   574 NEE--------------------YQPPEPREKLHKCPSCPREFTHKGNLMRHMETHDDSA 613
            ..|                    :|.....||.:||..|.:.|.......||..||.:.:
  Rat   665 TGEKPYECNQCGKTFSLSARLIVHQRTHTGEKPYKCSQCGKAFISSSKRSRHQATHSEES 724

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CTCF	NP_648109.1	23ISL	<116..206	CDD:293226	20/116 (17%)
		C2H2 Zn finger	296..316	CDD:275368	5/19 (26%)
		COG5048	321..>621	CDD:227381	103/313 (33%)
		zf-C2H2	322..344	CDD:278523	5/21 (24%)
		C2H2 Zn finger	324..344	CDD:275368	4/19 (21%)
		zf-H2C2_2	337..361	CDD:290200	9/23 (39%)
		C2H2 Zn finger	352..373	CDD:275368	9/20 (45%)
		C2H2 Zn finger	381..401	CDD:275368	5/19 (26%)
		zf-H2C2_2	394..415	CDD:290200	10/20 (50%)
		C2H2 Zn finger	409..429	CDD:275368	5/19 (26%)
		zf-H2C2_2	422..446	CDD:290200	11/23 (48%)
		C2H2 Zn finger	437..457	CDD:275368	8/19 (42%)
		C2H2 Zn finger	467..485	CDD:275368	6/17 (35%)
		C2H2 Zn finger	496..516	CDD:275370	4/19 (21%)
		C2H2 Zn finger	524..544	CDD:275368	5/19 (26%)
		zf-H2C2_2	536..561	CDD:290200	10/24 (42%)
		C2H2 Zn finger	552..573	CDD:275368	7/20 (35%)
		zf-C2H2	587..609	CDD:278523	6/21 (29%)
		C2H2 Zn finger	589..609	CDD:275368	5/19 (26%)
Zfp180	NP_653358.2	C2H2 Zn finger	368..384	CDD:275368	6/15 (40%)
		COG5048	369..723	CDD:227381	116/358 (32%)
		zf-C2H2	390..412	CDD:278523	5/21 (24%)
		C2H2 Zn finger	392..412	CDD:275368	5/19 (26%)
		zf-H2C2_2	404..429	CDD:290200	8/24 (33%)
		C2H2 Zn finger	420..440	CDD:275368	4/19 (21%)
		zf-H2C2_2	432..457	CDD:290200	9/24 (38%)
		C2H2 Zn finger	448..468	CDD:275368	9/20 (45%)
		zf-H2C2_2	461..485	CDD:290200	10/24 (42%)
		C2H2 Zn finger	476..496	CDD:275368	5/19 (26%)
		zf-H2C2_2	492..513	CDD:290200	9/20 (45%)
		C2H2 Zn finger	504..524	CDD:275368	5/19 (26%)
		zf-H2C2_2	520..541	CDD:290200	10/20 (50%)
		C2H2 Zn finger	532..552	CDD:275368	8/19 (42%)
		zf-H2C2_2	545..568	CDD:290200	11/24 (46%)
		C2H2 Zn finger	560..580	CDD:275368	6/20 (30%)
		zf-H2C2_2	573..597	CDD:290200	8/24 (33%)
		C2H2 Zn finger	588..608	CDD:275368	4/19 (21%)
		zf-H2C2_2	600..625	CDD:290200	9/24 (38%)
		C2H2 Zn finger	616..636	CDD:275368	5/19 (26%)
		zf-H2C2_2	629..653	CDD:290200	10/23 (43%)
		C2H2 Zn finger	644..664	CDD:275368	7/20 (35%)
		zf-H2C2_2	659..680	CDD:290200	3/21 (14%)
		C2H2 Zn finger	672..692	CDD:275368	1/19 (5%)
		zf-H2C2_2	685..707	CDD:290200	6/21 (29%)
		C2H2 Zn finger	700..720	CDD:275368	5/19 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910