DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CTCF and Zfp366

DIOPT Version :9

Sequence 1:	NP_648109.1	Gene:	CTCF / 38817	FlyBaseID:	FBgn0035769	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	NP_001004149.1	Gene:	Zfp366 / 238803	MGIID:	2178429	Length:	746	Species:	Mus musculus

Alignment Length:	720	Identity:	174/720 - (24%)
Similarity:	260/720 - (36%)	Gaps:	215/720 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 EAGGSKPMEEAEADLDHAEEAEEEEEDDEDKYFIDDEGNCYIKTTPKKQK-------------EL 105
            |.|||:..:.....:.:...|||.....|.| .:.......:...|::.|             :.
Mouse    72 EGGGSRKRKSMPTKVPYTHPAEEASIAQESK-SLGPPNLTLLFPQPQRPKCDSQMIDLCNVGLQF 135

  Fly   106 QKKLKQAAAKPGKATRSVVSTATNKSINLRPAKSTPKATTSKPPPEPKAISVRPARAAAAKAKQS 170
            .:.|:....||.|                               .||              .|.|
Mouse   136 YRTLEHLGGKPVK-------------------------------QEP--------------VKPS 155

  Fly   171 AM---PPPPALVVKVPAPRG-RPRKNP------VIPKPEPMDLERE--LEELVDEPDISSMVTEL 223
            ||   |.|||.   :|||.. .|:.:|      .:|...|....|.  |.:...||
Mouse   156 AMWPQPTPPAF---LPAPYPYYPKVHPGLMFPFFVPSSSPFPFSRHTFLPKQPPEP--------- 208

  Fly   224 SDYTVDEAAVEAATATLTPNEAEVYEFEDNATTEDENADKKDVDFVLSNKEVKLKTASSTSQNSN 288
                            :.|.:.|..|.|:.         |:.|:.|    :|.::...|...:..
Mouse   209 ----------------VLPRKVEPLESEET---------KQKVERV----DVNVQIDDSYYVDVG 244

  Fly   289 ASGHKYSCPHCPYTASKKFLITRHSRSHDVEPSFKCSICERSFRSNVGLQNHINTHMGNKPHKCK 353
            .:..::.||.|..:.:.|:.:..|...|.......||.|.:.|:....|..|:.||.|.:||||:
Mouse   245 GAQKRWQCPTCEKSYTSKYNLVTHILGHSGIKPHACSRCGKLFKQLSHLHTHMLTHQGTRPHKCQ 309

  Fly   354 LCESAFTTSGELVRHTRYKHTKEKPHKCTECT---------------YAS------VE------- 390
            :|..|||.:..|.|| ..:|::.|||.|..|:               :||      ||
Mouse   310 VCHKAFTQTSHLKRH-MMQHSEVKPHNCRVCSRGFAYPSELKAHEAKHASGRENICVECGLDFPT 373

  Fly   391 LTKLRRHMTCHTGERPYQCPHCTYASQDMFKLKRHMVIHTGEKKYQCDICKSRFTQSNSLKAHKL 455
            |.:|:||:|.|.|...|.|..|....|...:|:.||:.|...:.|.|..|...|.|.:.||.|.|
Mouse   374 LAQLKRHLTTHRGPIQYNCSECDKTFQYPSQLQNHMMKHKDIRPYICSECGMEFVQPHHLKQHSL 438

  Fly   456 IHSVVDKPVFQCNYCPTTCGRKADLRVHIKHMHTSDVPMTCRRCGQQLPDRYQYKLHVKSHEGEK 520
            .|..|.:  .:|.    .|||:..|..::|.                         ||..|...:
Mouse   439 THKGVKE--HKCG----ICGREFTLLANMKR-------------------------HVLIHTNIR 472

  Fly   521 CYSCKLCSYASVTQRHLASHMLIHLDEKPFHCDQCPQAFRQRQLLRRHMNLVHNEEYQPPEPREK 585
            .|.|.||..:.|.::.|.:||::|.|.|||.|..|.:.|.:...|..|::| |::        .|
Mouse   473 AYQCHLCYKSFVQKQTLKAHMIVHSDVKPFKCKLCGKEFNRMHNLMGHLHL-HSD--------SK 528

  Fly   586 LHKCPSCPREFTHKGNLMRHMETHDDSANAREKRRRLKLGRNVRLQKDGTVITLIKDQYVDMDR- 649
            ..||..||.:||.||||.|||:............:.|..||.|.:|..|.:..|.:::..|:.:
Mouse   529 PFKCLYCPSKFTLKGNLTRHMKVKHGVMERGLHSQGLGRGRLVLVQSAGVLRNLEQEEPFDLSQK 593

  Fly   650 ----------------------DQEENEEDDN-----PESYDLAEIEPENSE---AEDADDDVET 684
                                  ::||..|:||     |.|..||   ||:.:   .||.....|.
Mouse   594 RSANGPMFQSDVDSTQDCLCQEEEEEAGEEDNCYEVEPYSPSLA---PESQQLCAPEDLSTKQEQ 655

  Fly   685 IVSDP 689
            .:.||
Mouse   656 TLQDP 660

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CTCF	NP_648109.1	23ISL	<116..206	CDD:293226	19/99 (19%)
		C2H2 Zn finger	296..316	CDD:275368	5/19 (26%)
		COG5048	321..>621	CDD:227381	99/327 (30%)
		zf-C2H2	322..344	CDD:278523	6/21 (29%)
		C2H2 Zn finger	324..344	CDD:275368	6/19 (32%)
		zf-H2C2_2	337..361	CDD:290200	12/23 (52%)
		C2H2 Zn finger	352..373	CDD:275368	8/20 (40%)
		C2H2 Zn finger	381..401	CDD:275368	11/47 (23%)
		zf-H2C2_2	394..415	CDD:290200	9/20 (45%)
		C2H2 Zn finger	409..429	CDD:275368	6/19 (32%)
		zf-H2C2_2	422..446	CDD:290200	8/23 (35%)
		C2H2 Zn finger	437..457	CDD:275368	8/19 (42%)
		C2H2 Zn finger	467..485	CDD:275368	5/17 (29%)
		C2H2 Zn finger	496..516	CDD:275370	2/19 (11%)
		C2H2 Zn finger	524..544	CDD:275368	7/19 (37%)
		zf-H2C2_2	536..561	CDD:290200	11/24 (46%)
		C2H2 Zn finger	552..573	CDD:275368	6/20 (30%)
		zf-C2H2	587..609	CDD:278523	13/21 (62%)
		C2H2 Zn finger	589..609	CDD:275368	12/19 (63%)
Zfp366	NP_001004149.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..64
		FtsK	<51..>227	CDD:332908	41/237 (17%)
		COG5048	250..>546	CDD:227381	101/336 (30%)
		C2H2 Zn finger	252..272	CDD:275368	5/19 (26%)
		C2H2 Zn finger	280..300	CDD:275368	6/19 (32%)
		C2H2 Zn finger	308..328	CDD:275368	8/20 (40%)
		C2H2 Zn finger	336..356	CDD:275368	2/19 (11%)
		C2H2 Zn finger	364..384	CDD:275368	7/19 (37%)
		C2H2 Zn finger	392..412	CDD:275368	6/19 (32%)
		C2H2 Zn finger	420..440	CDD:275368	8/19 (42%)
		C2H2 Zn finger	448..468	CDD:275368	8/48 (17%)
		Interaction with NRIP1. /evidence=ECO:0000250\|UniProtKB:Q8N895	452..746		65/246 (26%)
		C2H2 Zn finger	476..496	CDD:275368	7/19 (37%)
		C2H2 Zn finger	504..524	CDD:275368	6/20 (30%)
		C2H2 Zn finger	532..551	CDD:275368	12/18 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	587..689		17/77 (22%)
		PXDLS. /evidence=ECO:0000250\|UniProtKB:Q8N895	587..591		1/3 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000