DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CTCF and Zfp454

DIOPT Version :9

Sequence 1:	NP_648109.1	Gene:	CTCF / 38817	FlyBaseID:	FBgn0035769	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	NP_001369380.1	Gene:	Zfp454 / 237758	MGIID:	2679253	Length:	536	Species:	Mus musculus

Alignment Length:	449	Identity:	138/449 - (30%)
Similarity:	200/449 - (44%)	Gaps:	58/449 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   206 ELEELVDEPDISSMVTELSD--YTVDEAAVEA---ATATLTPN------EAEVYEFEDNATTEDE 259
            |:||.|.|......|.:.:|  :....:|.||   .|..:|..      :|::.|.|.:.....|
Mouse    69 EVEECVSEEAPEGFVLDAADEPHLGPRSACEAQVPVTGEITVAMSKKFLKADIPEKESDQWIAKE 133

  Fly   260 NA----------------------DKKDVDFVLSNKEVKLKTASS-TSQNSNASGHKYSCPHCPY 301
            .|                      .:::....||.:.|:.:::|. .||.|.||...:.|..|..
Mouse   134 RACANLFNWQCQEGQEVKLQQVVLTQQNTPSKLSEQRVRAESSSPIQSQRSQASKTAFECSECGK 198

  Fly   302 TASKKFLITRHSRSH--DVEPS---------FKCSICERSFRSNVGLQNHINTHMGNKPHKCKLC 355
            ..||...:.:|.:.|  .:.||         :||..|.::|..:..|.:|...|.|.||::||.|
Mouse   199 AFSKSSTLKKHQKLHTEKLNPSQKSPMKEKRYKCRECGKAFHQSTHLIHHQRVHTGEKPYQCKDC 263

  Fly   356 ESAFTTSGELVRHTRYKHTKEKPHKCTECTYASVELTKLRRHMTCHTGERPYQCPHCTYASQDMF 420
            ..||:.|..|..|.:. ||.|||.:|..|..|.:....|..|...||||:|:||..|..|.....
Mouse   264 GKAFSVSSSLSYHQKI-HTGEKPFECNVCGKAFIRNIHLSHHHRMHTGEKPFQCNLCDKAFVCRA 327

  Fly   421 KLKRHMVIHTGEKKYQCDICKSRFTQSNSLKAHKLIHSVVDKPVFQCNYCPTTCGRKADLRVHIK 485
            .|.:|..||:|:|.|:|:.|...|.||.|...|:.||: .:|| |:||.|.......:.|..| :
Mouse   328 HLTKHQHIHSGKKPYKCNECGKAFNQSTSFLQHQRIHT-GEKP-FECNECGKAFRVNSSLTEH-Q 389

  Fly   486 HMHTSDVPMTCRRCGQQLPDRYQYKLHVKSHEGEKCYSCKLCSYASVTQRHLASHMLIHLDEKPF 550
            .:||.:.|..|..||:...|...:..|.|.|.|||.|.|.||..|...|..||.|...|..|||:
Mouse   390 RIHTGEKPYQCIECGKAFRDNSSFARHRKIHTGEKPYRCGLCEKAFRDQSALAQHQRTHTGEKPY 454

  Fly   551 HCDQCPQAFRQRQLLRRHMNLVHNEEYQPPEPREKLHKCPSCPREFTHKGNLMRHMETH 609
            .|:.|.:||.....|.:|.. :|.        |||.:||.:|.:.|....:|::|...|
Mouse   455 TCNICEKAFSDHSALTQHKR-IHT--------REKPYKCKTCGKAFIRSTHLIQHQRIH 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CTCF	NP_648109.1	23ISL	<116..206	CDD:293226	138/449 (31%)
		C2H2 Zn finger	296..316	CDD:275368	5/19 (26%)
		COG5048	321..>621	CDD:227381	105/298 (35%)
		zf-C2H2	322..344	CDD:278523	6/21 (29%)
		C2H2 Zn finger	324..344	CDD:275368	5/19 (26%)
		zf-H2C2_2	337..361	CDD:290200	11/23 (48%)
		C2H2 Zn finger	352..373	CDD:275368	8/20 (40%)
		C2H2 Zn finger	381..401	CDD:275368	5/19 (26%)
		zf-H2C2_2	394..415	CDD:290200	10/20 (50%)
		C2H2 Zn finger	409..429	CDD:275368	5/19 (26%)
		zf-H2C2_2	422..446	CDD:290200	10/23 (43%)
		C2H2 Zn finger	437..457	CDD:275368	7/19 (37%)
		C2H2 Zn finger	467..485	CDD:275368	5/17 (29%)
		C2H2 Zn finger	496..516	CDD:275370	6/19 (32%)
		C2H2 Zn finger	524..544	CDD:275368	8/19 (42%)
		zf-H2C2_2	536..561	CDD:290200	11/24 (46%)
		C2H2 Zn finger	552..573	CDD:275368	6/20 (30%)
		zf-C2H2	587..609	CDD:278523	6/21 (29%)
		C2H2 Zn finger	589..609	CDD:275368	5/19 (26%)
Zfp454	NP_001369380.1	KRAB	14..67	CDD:214630
		C2H2 Zn finger	193..213	CDD:275368	5/19 (26%)
		COG5048	197..532	CDD:227381	110/321 (34%)
		C2H2 Zn finger	232..252	CDD:275368	5/19 (26%)
		C2H2 Zn finger	260..280	CDD:275368	8/20 (40%)
		C2H2 Zn finger	288..308	CDD:275368	5/19 (26%)
		C2H2 Zn finger	316..336	CDD:275368	5/19 (26%)
		C2H2 Zn finger	344..364	CDD:275368	7/19 (37%)
		C2H2 Zn finger	372..392	CDD:275368	5/20 (25%)
		C2H2 Zn finger	400..420	CDD:275368	6/19 (32%)
		C2H2 Zn finger	428..448	CDD:275368	8/19 (42%)
		C2H2 Zn finger	456..476	CDD:275368	6/20 (30%)
		C2H2 Zn finger	484..504	CDD:275368	5/19 (26%)
		C2H2 Zn finger	512..532	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000