DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CTCF and Zfp612

DIOPT Version :9

Sequence 1:	NP_648109.1	Gene:	CTCF / 38817	FlyBaseID:	FBgn0035769	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	XP_006530970.1	Gene:	Zfp612 / 234725	MGIID:	2443465	Length:	735	Species:	Mus musculus

Alignment Length:	537	Identity:	139/537 - (25%)
Similarity:	208/537 - (38%)	Gaps:	116/537 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   224 SDYTVDEAAVEAATATLTPNEAEVYEFEDNATTEDENADKKDVDFVLSNKEVKLKTASSTSQNSN 288
            :|.....::||....:.||..::.:.........|....|.: ......:.:|.:..:..||.|.
Mouse   210 TDGRAKASSVEGCLFSQTPQLSQDHTSSTGELYSDTKLSKSE-RITTEERPLKPRELAEASQGSP 273

  Fly   289 ASGH---------KYSCPHCPYTASKKFLITRHSRSHDVEPSFKCSICERSFRSNVGLQNHINTH 344
            ....         .|.|..|....|.|.....|.|.|:.|..|||..|.:.|..:.....|...|
Mouse   274 QVNQLPEICDVEKPYQCAECGKAFSVKAKFVWHQRLHNGEKPFKCVECGKCFSYSSHYITHQTIH 338

  Fly   345 MGNKPHKCKLCESAFTTSGELVRHTRYKHTKEKPHKCTEC----TYASVELTKLRRHMTCHTGER 405
            .|.||::||:|..||:.:|.||||.|. ||.|||::|.:|    ..:|..:|    |...||||:
Mouse   339 SGEKPYQCKVCGKAFSVNGSLVRHQRI-HTGEKPYQCKDCGAGFGCSSAYIT----HQRTHTGEK 398

  Fly   406 PYQCPHCTYASQDMFKLKRHMVIHTGEKKYQCDICKSRFTQSNSLKAHKLIHS------------ 458
            ||:|..|..|.....||.:|..||||||.|:||:|...|..|..|:.|:.||:
Mouse   399 PYECSDCGKAFNVNAKLIQHQRIHTGEKPYECDVCGKGFRCSTQLRQHQSIHTGEKPHRCSECGK 463

  Fly   459 ---------------VVDKPVFQCNYCPTT------------------------CGR----KADL 480
                           ..:|| :.|:.|..|                        ||:    .:.|
Mouse   464 GFTKNAKLIQHQRVHTGEKP-YACSDCGKTFSAKGKLIQHQRIHTGERPYECSECGKSFRCNSQL 527

  Fly   481 RVHIKHMHTSDVPMTCRRCGQQLPDRYQYKLHVKSHEGEKCYSCKLCSYASVTQRHLASHMLIHL 545
            |.|:: :||.:.|..|..||:......:...|.::|.|||.:.||.|.....::|:|..|...|.
Mouse   528 RQHLR-IHTGEKPYKCSECGKAFNVNAKLMQHRRTHTGEKPFECKECGKCFTSKRNLLDHQRAHT 591

  Fly   546 DEKPFHCDQCPQAFRQRQLLRRHMNLVHNEE--------------------YQPPEPREKLHKCP 590
            .|||:.|.:|.:||.....|.||.. :|..|                    :|.....||..:|.
Mouse   592 GEKPYQCSECGKAFSINAKLTRHQQ-IHTREKPFKCMECEKAFSCSSDYIVHQRIHTGEKPFQCG 655

  Fly   591 SCPREFTHKGNLMRHMETHDDSANAREKRRRLKLGRNVRLQKDGTVITLI---KDQYV------- 645
            .|.:.|....:|:||..:|    ...:..|..:.|:...|..|..:...:   |..||
Mouse   656 ECGKAFHVNAHLIRHQRSH----TGEKPFRCTECGKGFSLSSDCIIHQTVHTWKKPYVCNVCGKT 716

  Fly   646 -----DMDRDQEENEED 657
                 .:.:.|:.:.||
Mouse   717 FRFSFQLSQHQDVHNED 733

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CTCF	NP_648109.1	23ISL	<116..206	CDD:293226
		C2H2 Zn finger	296..316	CDD:275368	6/19 (32%)
		COG5048	321..>621	CDD:227381	109/378 (29%)
		zf-C2H2	322..344	CDD:278523	6/21 (29%)
		C2H2 Zn finger	324..344	CDD:275368	4/19 (21%)
		zf-H2C2_2	337..361	CDD:290200	10/23 (43%)
		C2H2 Zn finger	352..373	CDD:275368	11/20 (55%)
		C2H2 Zn finger	381..401	CDD:275368	5/23 (22%)
		zf-H2C2_2	394..415	CDD:290200	9/20 (45%)
		C2H2 Zn finger	409..429	CDD:275368	6/19 (32%)
		zf-H2C2_2	422..446	CDD:290200	13/23 (57%)
		C2H2 Zn finger	437..457	CDD:275368	7/19 (37%)
		C2H2 Zn finger	467..485	CDD:275368	8/45 (18%)
		C2H2 Zn finger	496..516	CDD:275370	4/19 (21%)
		C2H2 Zn finger	524..544	CDD:275368	6/19 (32%)
		zf-H2C2_2	536..561	CDD:290200	10/24 (42%)
		C2H2 Zn finger	552..573	CDD:275368	7/20 (35%)
		zf-C2H2	587..609	CDD:278523	6/21 (29%)
		C2H2 Zn finger	589..609	CDD:275368	6/19 (32%)
Zfp612	XP_006530970.1	KRAB	74..134	CDD:214630
		C2H2 Zn finger	290..310	CDD:275368	6/19 (32%)
		COG5048	314..720	CDD:227381	116/417 (28%)
		C2H2 Zn finger	318..338	CDD:275368	4/19 (21%)
		C2H2 Zn finger	346..366	CDD:275368	11/20 (55%)
		C2H2 Zn finger	374..394	CDD:275368	5/23 (22%)
		C2H2 Zn finger	402..422	CDD:275368	6/19 (32%)
		C2H2 Zn finger	430..450	CDD:275368	7/19 (37%)
		C2H2 Zn finger	458..478	CDD:275368	0/19 (0%)
		C2H2 Zn finger	486..506	CDD:275368	3/19 (16%)
		C2H2 Zn finger	514..534	CDD:275368	5/20 (25%)
		C2H2 Zn finger	542..562	CDD:275368	4/19 (21%)
		C2H2 Zn finger	570..590	CDD:275368	6/19 (32%)
		C2H2 Zn finger	598..618	CDD:275368	7/20 (35%)
		C2H2 Zn finger	626..646	CDD:275368	1/19 (5%)
		C2H2 Zn finger	654..674	CDD:275368	6/19 (32%)
		C2H2 Zn finger	682..702	CDD:275368	3/19 (16%)
		C2H2 Zn finger	710..730	CDD:275368	1/19 (5%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000