DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CTCF and Zim1

DIOPT Version :9

Sequence 1:	NP_648109.1	Gene:	CTCF / 38817	FlyBaseID:	FBgn0035769	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	NP_035899.4	Gene:	Zim1 / 22776	MGIID:	1341879	Length:	579	Species:	Mus musculus

Alignment Length:	622	Identity:	157/622 - (25%)
Similarity:	241/622 - (38%)	Gaps:	143/622 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LQTFLNNFHKEIEGNSDEKVVN-----------TILEAISAEAIDL---------DENGAEAGGS 58
            |:....:.:|::...:.|.:::           |.||    :.:||         |....|||.|
Mouse    67 LEPAQKDLYKDVMLENYENLISVEYYIFKPKLITRLE----QGVDLFAKENDVPGDPQQGEAGVS 127

  Fly    59 KPMEEA-EADLDHAEEAEEEEEDDEDKYFIDDEGNCYIKTTPKKQKELQKKLKQAAAKPGKATRS 122
            :....| :...|::.:||..:.|:.             |||..:        ||.||..|:.::|
Mouse   128 RSDTSAGKKTGDNSTKAEIRKPDNS-------------KTTSLE--------KQKAADQGRGSQS 171

  Fly   123 VVSTATNKSINLRPAKSTPKATTSKPPPEPKAISVRPARAAAAKAKQSAMPPPPALVVKVPAPRG 187
            :.:..|:||.: ||:::..|.                |..:..:|.::::|             |
Mouse   172 LRAEKTSKSDD-RPSQNKEKC----------------ASTSTTEASKTSIP-------------G 206

  Fly   188 RPRKNPVIPKPEPMDLERELEELVDEPDISSMVTELSDYTVDEAAVEAATATLTPNEAEVYEFED 252
            .......||                                ..::.:.:.||.||..|
Mouse   207 NKENESAIP--------------------------------GTSSGQTSAATTTPQSA------- 232

  Fly   253 NATTEDENADKKDVDFVLSNKEVKLKTASSTSQN-----SNASGHKYSCPHCPYTASKKFLITRH 312
               ..::....|||       |.|.:|..|:|.|     :....:.:.|..|..|.::...:..|
Mouse   233 ---PSEKPTSGKDV-------EGKPQTMRSSSTNPKRKPARQGKNHFKCKECGKTFNQTLHLVEH 287

  Fly   313 SRSHDVEPSFKCSICERSFRSNVGLQNHINTHMGNKPHKCKLCESAFTTSGELVRHTRYKHTKEK 377
            .|.|..|...||..|.:|||.......|...|.|.:|:|||.|..||.:|..|..|.|. |:.||
Mouse   288 ERIHTGEKPHKCDTCGKSFRHLSYFLTHYRIHTGVRPYKCKECGKAFNSSSTLNNHCRI-HSGEK 351

  Fly   378 PHKCTECTYASVELTKLRRHMTCHTGERPYQCPHCTYASQDMFKLKRHMVIHTGEKKYQCDICKS 442
            |.||.||.....:.|||.||...||||:||:|..|.........|:.|..||||||.|.|.:|..
Mouse   352 PFKCDECGKTFKQSTKLTRHQRIHTGEKPYKCGECNKCFGRSSSLREHKRIHTGEKPYCCQVCGK 416

  Fly   443 RFTQSNSLKAHKLIHSVVDKPVFQCNYCPTTCGRKADLRVHIKHMHTSDVPMTCRRCGQQLPDRY 507
            .|..::.|..|:.:|..| || ::|:.|.......:.|..| |.:|.....:.|..||:....:.
Mouse   417 TFRVNSHLSEHQRLHLKV-KP-YKCDKCGKHFRNSSYLTEH-KQIHVPGARVDCPECGKVFACKV 478

  Fly   508 QYKLHVKSHEGEKCYSCKLCSYASVTQRHLASHMLIHLDEKPFHCDQCPQAFRQRQLLRRHMNLV 572
            ....|.|.||....|.||.|......:..:..|..:|..||||.|.:|.:.|..:..|..|:. :
Mouse   479 ALLKHQKRHEANSRYRCKGCGKTFRCKSSIQRHERLHAGEKPFVCHKCDKGFTDKTTLNNHLK-I 542

  Fly   573 HNEEYQPPEPREKLHKCPSCPREFTHKGNLMRHMETH 609
            |:.:  .|:|      |..|.|.|.....|:.|.:.|
Mouse   543 HSGD--RPDP------CAQCGRTFKKLATLLIHQKKH 571

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CTCF	NP_648109.1	23ISL	<116..206	CDD:293226	14/89 (16%)
		C2H2 Zn finger	296..316	CDD:275368	5/19 (26%)
		COG5048	321..>621	CDD:227381	97/289 (34%)
		zf-C2H2	322..344	CDD:278523	7/21 (33%)
		C2H2 Zn finger	324..344	CDD:275368	6/19 (32%)
		zf-H2C2_2	337..361	CDD:290200	10/23 (43%)
		C2H2 Zn finger	352..373	CDD:275368	9/20 (45%)
		C2H2 Zn finger	381..401	CDD:275368	8/19 (42%)
		zf-H2C2_2	394..415	CDD:290200	11/20 (55%)
		C2H2 Zn finger	409..429	CDD:275368	4/19 (21%)
		zf-H2C2_2	422..446	CDD:290200	12/23 (52%)
		C2H2 Zn finger	437..457	CDD:275368	5/19 (26%)
		C2H2 Zn finger	467..485	CDD:275368	4/17 (24%)
		C2H2 Zn finger	496..516	CDD:275370	5/19 (26%)
		C2H2 Zn finger	524..544	CDD:275368	4/19 (21%)
		zf-H2C2_2	536..561	CDD:290200	9/24 (38%)
		C2H2 Zn finger	552..573	CDD:275368	5/20 (25%)
		zf-C2H2	587..609	CDD:278523	6/21 (29%)
		C2H2 Zn finger	589..609	CDD:275368	6/19 (32%)
Zim1	NP_035899.4	KRAB	50..105	CDD:214630	6/41 (15%)
		PRK13335	137..>269	CDD:139494	39/231 (17%)
		COG5048	<226..427	CDD:227381	74/218 (34%)
		C2H2 Zn finger	271..291	CDD:275368	5/19 (26%)
		C2H2 Zn finger	299..319	CDD:275368	6/19 (32%)
		C2H2 Zn finger	327..347	CDD:275368	9/20 (45%)
		C2H2 Zn finger	355..375	CDD:275368	8/19 (42%)
		C2H2 Zn finger	383..403	CDD:275368	4/19 (21%)
		C2H2 Zn finger	411..431	CDD:275368	5/19 (26%)
		zf-C2H2	437..459	CDD:333835	5/22 (23%)
		C2H2 Zn finger	439..459	CDD:275368	5/20 (25%)
		C2H2 Zn finger	467..487	CDD:275368	5/19 (26%)
		C2H2 Zn finger	495..515	CDD:275368	4/19 (21%)
		zf-C2H2	521..543	CDD:333835	6/22 (27%)
		C2H2 Zn finger	523..543	CDD:275368	5/20 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000