DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CTCF and Zfp51

DIOPT Version :9

Sequence 1:	NP_648109.1	Gene:	CTCF / 38817	FlyBaseID:	FBgn0035769	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	NP_001295252.1	Gene:	Zfp51 / 22709	MGIID:	99198	Length:	781	Species:	Mus musculus

Alignment Length:	513	Identity:	152/513 - (29%)
Similarity:	218/513 - (42%)	Gaps:	131/513 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   206 ELEELVDEPDISSMVTELSDYTVDEAAVEAATATLTPNEAEVYEFEDNAT------TEDENADKK 264
            :|.|::.||...::... ||.|      ||:......|..:|.....|..      |.:|..:.|
Mouse   106 KLGEMLHEPSNCALYNR-SDTT------EASNKFRCCNNEDVSVDSSNQNRYKSTHTGEEPCESK 163

  Fly   265 DVDFVLSNKEVKLKTASSTSQNS---NASGHK-----------YS-----------------CPH 298
            |.       |..|...|..||:.   ||..|:           ||                 |..
Mouse   164 DC-------EKSLTLCSDISQDQRLYNAKQHRQEVYDDYFSSAYSLMQPTAYIKEKPHQCGKCGK 221

  Fly   299 CPYTASKKFLITRHSRSHDVEPSFKCSICERSFRSNVGLQNHINTHMGNKPHKCKLCESAFTTSG 363
            |..|:|.   :|.|.|.|..|..:|||:|::||.....|:.|...|.|.||:|||.||.:|....
Mouse   222 CFNTSSS---LTVHHRIHTKEKPYKCSVCDKSFTQCTHLKIHQRRHTGEKPYKCKECEKSFVQLS 283

  Fly   364 ELVRHTRYKHTKEKPHKCTEC-----------TYASV-----------------ELTKLRRHMTC 400
            .|..|.:. ||.|||:||.||           |:..:                 :|:.||:|...
Mouse   284 ALKSHQKL-HTGEKPYKCKECDKSFAHYPNFRTHQKIHTSEEHCSCPECGREFHQLSHLRKHYRL 347

  Fly   401 HTGERPYQCPHCT-----YASQ-----------------------DMFKLKRHMVIHTGEKKYQC 437
            ||||:||:|..|.     |||.                       ::..||||..||||||.|:|
Mouse   348 HTGEKPYKCNECDRSFTHYASLRWHQKTHTPEIHYECKECGKSFIELSHLKRHYRIHTGEKPYKC 412

  Fly   438 DICKSRFTQSNSLKAHKLIHSVVDKPVFQCNYCPTTCGRKADLRVHIKHMHTSDVPMTCRRCGQQ 502
            :||...||.:.:||.|:.||: .:|| ::|..|..:....:.||.| :::||.:.|..|:.|.:.
Mouse   413 EICDKSFTTTTTLKTHQKIHT-GEKP-YKCRECDKSFIHSSHLRRH-QNVHTGERPYRCKECDKS 474

  Fly   503 LPDRYQYKLHVKSHEGEKCYSCKLCSYASVTQR-HLAS-HMLIHLDEKPFHCDQCPQAFRQRQLL 565
            ..:....:.|.|||.|||.|.|:.|. .|.||| :|.: |..:|..|:|:.|.:|.::|.....|
Mouse   475 FHESATLREHEKSHTGEKTYKCRECD-KSFTQRAYLRNHHNRVHTGERPYECKECGKSFTTCSTL 538

  Fly   566 RRHMNLVHNEEYQPPEPREKLHKCPSCPREFTHKGNLMRHMETHDDSANAREKRRRLK 623
            |.|.. :|.        .:|.:||..|.:.||:...|..|.:.|     :.||..|.|
Mouse   539 RIHQT-IHT--------GKKPYKCIECGKSFTNNSYLRTHQKVH-----SGEKPYRCK 582

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CTCF	NP_648109.1	23ISL	<116..206	CDD:293226	152/513 (30%)
		C2H2 Zn finger	296..316	CDD:275368	7/19 (37%)
		COG5048	321..>621	CDD:227381	115/357 (32%)
		zf-C2H2	322..344	CDD:278523	8/21 (38%)
		C2H2 Zn finger	324..344	CDD:275368	7/19 (37%)
		zf-H2C2_2	337..361	CDD:290200	12/23 (52%)
		C2H2 Zn finger	352..373	CDD:275368	7/20 (35%)
		C2H2 Zn finger	381..401	CDD:275368	8/47 (17%)
		zf-H2C2_2	394..415	CDD:290200	11/25 (44%)
		C2H2 Zn finger	409..429	CDD:275368	9/47 (19%)
		zf-H2C2_2	422..446	CDD:290200	15/23 (65%)
		C2H2 Zn finger	437..457	CDD:275368	8/19 (42%)
		C2H2 Zn finger	467..485	CDD:275368	5/17 (29%)
		C2H2 Zn finger	496..516	CDD:275370	4/19 (21%)
		C2H2 Zn finger	524..544	CDD:275368	8/21 (38%)
		zf-H2C2_2	536..561	CDD:290200	8/25 (32%)
		C2H2 Zn finger	552..573	CDD:275368	6/20 (30%)
		zf-C2H2	587..609	CDD:278523	7/21 (33%)
		C2H2 Zn finger	589..609	CDD:275368	6/19 (32%)
Zfp51	NP_001295252.1	KRAB	42..82	CDD:366587
		C2H2 Zn finger	216..236	CDD:275368	7/22 (32%)
		SFP1	<239..318	CDD:227516	31/79 (39%)
		C2H2 Zn finger	244..264	CDD:275368	7/19 (37%)
		C2H2 Zn finger	272..292	CDD:275368	7/20 (35%)
		C2H2 Zn finger	300..320	CDD:275368	4/19 (21%)
		COG5048	327..749	CDD:227381	87/274 (32%)
		C2H2 Zn finger	356..376	CDD:275368	5/19 (26%)
		C2H2 Zn finger	384..404	CDD:275368	4/19 (21%)
		C2H2 Zn finger	412..432	CDD:275368	8/19 (42%)
		C2H2 Zn finger	440..460	CDD:275368	5/20 (25%)
		C2H2 Zn finger	468..488	CDD:275368	4/19 (21%)
		C2H2 Zn finger	496..517	CDD:275368	8/21 (38%)
		C2H2 Zn finger	525..545	CDD:275368	6/20 (30%)
		C2H2 Zn finger	553..573	CDD:275368	6/19 (32%)
		C2H2 Zn finger	581..601	CDD:275368	1/2 (50%)
		C2H2 Zn finger	609..629	CDD:275368
		C2H2 Zn finger	637..657	CDD:275368
		C2H2 Zn finger	665..685	CDD:275368
		C2H2 Zn finger	693..713	CDD:275368
		C2H2 Zn finger	721..741	CDD:275368
		C2H2 Zn finger	749..769	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000