DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CTCF and Zscan2

DIOPT Version :9

Sequence 1:	NP_648109.1	Gene:	CTCF / 38817	FlyBaseID:	FBgn0035769	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	NP_001369440.1	Gene:	Zscan2 / 22691	MGIID:	99176	Length:	614	Species:	Mus musculus

Alignment Length:	634	Identity:	158/634 - (24%)
Similarity:	230/634 - (36%)	Gaps:	191/634 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   136 PAKSTPKATTSKPPPE---------------------------PKAISVRPARAAAAKA----KQ 169
            ||.|||.:...:.|.|                           |::   .|...:|.|.    :.
Mouse     6 PAVSTPLSPLVQVPQEEDEQAEVTTMILEDDAWVQEAVLQEDGPES---EPFPQSAGKGSPQEED 67

  Fly   170 SAMPPPPALVVKVPAPRGRPRK------NPVIPKPEPM--DLERELEELVDE--PDISSMVTELS 224
            :|..|..|||        |.|:      .|.:...|.|  .|.||::..:.|  |:.|....
Mouse    68 AAEGPQGALV--------RFRELCRRWLRPEVHTKEQMLTVLPREIQAWLQEHRPESSEEAV--- 121

  Fly   225 DYTVDEAAVEAATATLTPNEAEVYEFEDNATTED--ENADKKDVDFVLSNKEVKLKTASSTS--- 284
                  |.||..|.|...::.|:.......:.||  |..:...:...:|..|...::...:.
Mouse   122 ------ALVEDLTQTFRHSDFEIQSENGENSNEDMFEGVESHGMFLNISGGEGGQQSDGDSDFER 180

  Fly   285 --QNSNASGH------------------------------KYSCPHCPYTASKKFLITRHSRSHD 317
              .:..|.||                              .|.||.|..|.|:|..:..|.|:|.
Mouse   181 DCGSGGAQGHAPGEDPRVVPSEGREVGQLIGLQGTYLGEKPYECPQCGKTFSRKSHLITHERTHT 245

  Fly   318 VEPSFKCSICERSFRSNVGLQNHINTHMGNKPHKCKLCESAFTTSGELVRHTRYKHTKEKPHKCT 382
            .|..:||..|.:||........|..||.|.||:||:.|..:|:.|..|:.|.|. ||.|||.:|.
Mouse   246 GEKYYKCDECGKSFSDGSNFSRHQTTHTGEKPYKCRDCGKSFSRSANLITHQRI-HTGEKPFQCA 309

  Fly   383 ECTYASVELTKLRRHMTCHTGERPYQCPHC---------------------TYASQDM------- 419
            ||..:......|..|...||||:||.||.|                     .||.::.
Mouse   310 ECGKSFSRSPNLIAHQRTHTGEKPYSCPECGKSFGNRSSLNTHQGIHTGEKPYACKECGESFSYN 374

  Fly   420 FKLKRHMVIHTGEKKYQCDICKSRFTQSNSLKAHKLIHS-------------------------- 458
            ..|.||..||||||.|:|..|..:|:||::|..|:..|:
Mouse   375 SNLIRHQRIHTGEKPYKCTECGQKFSQSSALITHRRTHTGEKPYQCGECGKNFSRSSNLATHRRT 439

  Fly   459 -VVDKPVFQCNYCPTTCGRKADLRVH-------------------------IKHM--HTSDVPMT 495
             :|:|| ::|..|..:..:.:.|..|                         |||.  ||.:.|..
Mouse   440 HLVEKP-YKCGLCGKSFSQSSSLIAHQGTHTGEKPYECLTCGESFSWSSNLIKHQRTHTGEKPYR 503

  Fly   496 CRRCGQQLPDRYQYKLHVKSHEGEKCYSCKLCSYASVTQRHLASHMLIHLDEKPFHCDQCPQAFR 560
            |..||:....|.|..:|.::|.|||.|.|.:|..:......|..|...||.:||:.|.:|.:.|.
Mouse   504 CGDCGKGFSQRSQLVVHQRTHTGEKPYKCLMCGKSFSRGSILVMHQRAHLGDKPYRCPECGKGFS 568

  Fly   561 QRQLLRRHMNLVHNEEYQPPEPREKLHKCPSCPREFTHKGNLMRHMETH 609
            ...:|..|.. :|.        .||.::||.|.:.|::..|.:.|..||
Mouse   569 WNSVLIIHQR-IHT--------GEKPYRCPECGKGFSNSSNFITHQRTH 608

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CTCF	NP_648109.1	23ISL	<116..206	CDD:293226	22/108 (20%)
		C2H2 Zn finger	296..316	CDD:275368	8/19 (42%)
		COG5048	321..>621	CDD:227381	106/371 (29%)
		zf-C2H2	322..344	CDD:278523	6/21 (29%)
		C2H2 Zn finger	324..344	CDD:275368	5/19 (26%)
		zf-H2C2_2	337..361	CDD:290200	10/23 (43%)
		C2H2 Zn finger	352..373	CDD:275368	7/20 (35%)
		C2H2 Zn finger	381..401	CDD:275368	5/19 (26%)
		zf-H2C2_2	394..415	CDD:290200	11/41 (27%)
		C2H2 Zn finger	409..429	CDD:275368	8/47 (17%)
		zf-H2C2_2	422..446	CDD:290200	13/23 (57%)
		C2H2 Zn finger	437..457	CDD:275368	7/19 (37%)
		C2H2 Zn finger	467..485	CDD:275368	4/42 (10%)
		C2H2 Zn finger	496..516	CDD:275370	6/19 (32%)
		C2H2 Zn finger	524..544	CDD:275368	4/19 (21%)
		zf-H2C2_2	536..561	CDD:290200	9/24 (38%)
		C2H2 Zn finger	552..573	CDD:275368	5/20 (25%)
		zf-C2H2	587..609	CDD:278523	6/21 (29%)
		C2H2 Zn finger	589..609	CDD:275368	6/19 (32%)
Zscan2	NP_001369440.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25		7/18 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	42..73		5/33 (15%)
		SCAN	69..131	CDD:396558	20/78 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	162..200		5/37 (14%)
		COG5048	220..600	CDD:227381	113/390 (29%)
		C2H2 Zn finger	224..244	CDD:275368	8/19 (42%)
		C2H2 Zn finger	252..272	CDD:275368	5/19 (26%)
		C2H2 Zn finger	280..300	CDD:275368	7/20 (35%)
		C2H2 Zn finger	308..328	CDD:275368	5/19 (26%)
		C2H2 Zn finger	336..356	CDD:275368	3/19 (16%)
		C2H2 Zn finger	364..384	CDD:275368	3/19 (16%)
		C2H2 Zn finger	392..412	CDD:275368	7/19 (37%)
		C2H2 Zn finger	420..440	CDD:275368	0/19 (0%)
		C2H2 Zn finger	448..468	CDD:275368	4/19 (21%)
		C2H2 Zn finger	476..496	CDD:275368	3/19 (16%)
		C2H2 Zn finger	504..524	CDD:275368	6/19 (32%)
		C2H2 Zn finger	532..552	CDD:275368	4/19 (21%)
		C2H2 Zn finger	560..580	CDD:275368	5/20 (25%)
		C2H2 Zn finger	588..608	CDD:275368	6/19 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000