DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CTCF and Zfp26

DIOPT Version :9

Sequence 1:	NP_648109.1	Gene:	CTCF / 38817	FlyBaseID:	FBgn0035769	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	XP_011240753.1	Gene:	Zfp26 / 22688	MGIID:	99173	Length:	965	Species:	Mus musculus

Alignment Length:	383	Identity:	120/383 - (31%)
Similarity:	172/383 - (44%)	Gaps:	68/383 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   283 TSQNSNASGHK-YSCPHCPYTASKKFLITRHSRSHDVEPSFKCSICERSFRSNVGLQNHINTHMG 346
            |....:.:|.| |.|..|....:....:|.|.|:|..|..|:|:||.::|..:..|..||.||.|
Mouse   422 TEHMRSHTGEKPYQCDQCGNAFASSSYLTTHLRTHTGEKPFECNICGKAFTRSSYLLGHIRTHTG 486

  Fly   347 NKPHKCKLCESAFTTSGELVRHTRYKHTKEKPHKCTECTYASVELTKLRRHMTCHTGERPYQCPH 411
            .||::||:|..||:....|..|.| |||.|:|:.||||..|.....:|..|:..||||:|::|..
Mouse   487 EKPYECKVCGKAFSGRSWLTIHLR-KHTGERPYPCTECEKAFTSFAQLTEHIKTHTGEKPFRCKV 550

  Fly   412 CTYASQDMFKLKRHMVIHTGEKKYQCDICKSRFTQSNSLKAHKLIH------------------- 457
            |....::...||.|..||||.|.|:|:.|...||..:.|..|.|||
Mouse   551 CARTFRNSSCLKTHFRIHTGIKPYKCNYCGKAFTARSGLTKHVLIHNGEKPYECKECGKAFSTSS 615

  Fly   458 ----------------------------SVV--------DKPVFQCNYCPTTCGRKADLRVHIKH 486
                                        |:|        :|| |:||.|..|..|.:.||:|::
Mouse   616 GLVEHIRIHTGEKPFECYQCGKALAHSSSLVGHLRTHTGEKP-FECNQCDKTFTRSSYLRIHMR- 678

  Fly   487 MHTSDVPMTCRRCGQQLPDRYQYKLHVKSHEGEKCYSCKLCSYASVTQRHLASHMLIHLDEKPFH 551
            .||.:.|..|:.||:..|:|.....|:::|.||:.|.||.|....::...|..|:..|..|:||.
Mouse   679 THTGEKPYECKECGKTFPERSCLTKHIRTHTGERPYECKECGKGFISFAQLTVHIKTHSSERPFQ 743

  Fly   552 CDQCPQAFRQRQLLRRHMNLVHNEEYQPPEPREKLHKCPSCPREFTHKGNLMRHMETH 609
            |..|.::||....|..|.. :|.        ..|.:||..|.:.||.:..|..|:..|
Mouse   744 CKVCTKSFRNSSSLETHFR-IHT--------GVKPYKCSYCGKAFTARSGLTIHLRNH 792

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CTCF	NP_648109.1	23ISL	<116..206	CDD:293226
		C2H2 Zn finger	296..316	CDD:275368	5/19 (26%)
		COG5048	321..>621	CDD:227381	109/344 (32%)
		zf-C2H2	322..344	CDD:278523	8/21 (38%)
		C2H2 Zn finger	324..344	CDD:275368	7/19 (37%)
		zf-H2C2_2	337..361	CDD:290200	13/23 (57%)
		C2H2 Zn finger	352..373	CDD:275368	8/20 (40%)
		C2H2 Zn finger	381..401	CDD:275368	7/19 (37%)
		zf-H2C2_2	394..415	CDD:290200	9/20 (45%)
		C2H2 Zn finger	409..429	CDD:275368	5/19 (26%)
		zf-H2C2_2	422..446	CDD:290200	12/23 (52%)
		C2H2 Zn finger	437..457	CDD:275368	7/19 (37%)
		C2H2 Zn finger	467..485	CDD:275368	8/17 (47%)
		C2H2 Zn finger	496..516	CDD:275370	6/19 (32%)
		C2H2 Zn finger	524..544	CDD:275368	5/19 (26%)
		zf-H2C2_2	536..561	CDD:290200	9/24 (38%)
		C2H2 Zn finger	552..573	CDD:275368	6/20 (30%)
		zf-C2H2	587..609	CDD:278523	7/21 (33%)
		C2H2 Zn finger	589..609	CDD:275368	6/19 (32%)
Zfp26	XP_011240753.1	KRAB	113..171	CDD:214630
		C2H2 Zn finger	297..317	CDD:275368
		COG5048	325..760	CDD:227381	109/340 (32%)
		C2H2 Zn finger	352..372	CDD:275368
		C2H2 Zn finger	380..400	CDD:275368
		C2H2 Zn finger	408..428	CDD:275368	1/5 (20%)
		C2H2 Zn finger	436..456	CDD:275368	5/19 (26%)
		C2H2 Zn finger	464..484	CDD:275368	7/19 (37%)
		C2H2 Zn finger	492..512	CDD:275368	8/20 (40%)
		C2H2 Zn finger	520..540	CDD:275368	7/19 (37%)
		C2H2 Zn finger	548..568	CDD:275368	5/19 (26%)
		C2H2 Zn finger	576..596	CDD:275368	7/19 (37%)
		COG5048	600..956	CDD:227381	51/204 (25%)
		C2H2 Zn finger	604..624	CDD:275368	0/19 (0%)
		C2H2 Zn finger	632..652	CDD:275368	2/19 (11%)
		C2H2 Zn finger	660..680	CDD:275368	8/20 (40%)
		C2H2 Zn finger	688..708	CDD:275368	6/19 (32%)
		C2H2 Zn finger	716..736	CDD:275368	5/19 (26%)
		C2H2 Zn finger	744..764	CDD:275368	6/20 (30%)
		C2H2 Zn finger	772..792	CDD:275368	6/19 (32%)
		C2H2 Zn finger	800..820	CDD:275368
		C2H2 Zn finger	828..848	CDD:275368
		C2H2 Zn finger	856..876	CDD:275368
		C2H2 Zn finger	884..904	CDD:275368
		C2H2 Zn finger	912..932	CDD:275368
		C2H2 Zn finger	940..956	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000