DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CTCF and Zfp7

DIOPT Version :9

Sequence 1:	NP_648109.1	Gene:	CTCF / 38817	FlyBaseID:	FBgn0035769	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	NP_001345745.1	Gene:	Zfp7 / 223669	MGIID:	99208	Length:	685	Species:	Mus musculus

Alignment Length:	405	Identity:	116/405 - (28%)
Similarity:	170/405 - (41%)	Gaps:	76/405 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   272 NKEVKLKTASS---TSQNSNASGHKYSCPHCPYTASKKF----LITRHSRSHDVEPSFKCSICER 329
            ||..|:..:||   ..|.::.....:.|..|    .|:|    ::|:|.|.|..|..|||:.|.:
Mouse   223 NKCTKVFASSSRLIRHQRAHTGEKPFKCDQC----GKRFVLASVLTQHQRIHTGERPFKCAECGK 283

  Fly   330 SFRSNVGLQNHINTHMGNKPHKCKLCESAFTTSGELVRHTRYKHTKEKPHKCTECTYASVELTKL 394
            .|..:..|..|...|.|.||::|:.|...|..|..||.|.|. ||.|:|..|.||..|..:.::|
Mouse   284 GFHLSAKLVQHQRIHTGEKPYRCEECGKTFGQSSSLVHHQRI-HTGERPFICQECGKAFCQRSQL 347

  Fly   395 RRHMTCHTGERPYQCPHC--------TYASQD--------------------------------- 418
            .||...|||||||.|..|        |.|...
Mouse   348 SRHRRTHTGERPYSCQECGKAFCQRATLAQHQKMMHTAEKSQMPRASESPSLIACQGNTTEEKPF 412

  Fly   419 -----------MFKLKRHMVIHTGEKKYQCDICKSRFTQSNSLKAHKLIHSVVDKPVFQCNYCPT 472
                       :.:|.:|.|:|:|||.|||:.|...|..::.|..|:..|: .:|| |:|:.|..
Mouse   413 KCEQCGKAFRWLSRLNQHQVVHSGEKPYQCNKCSKAFGCTSRLIRHQRTHT-GEKP-FKCDECGK 475

  Fly   473 TCGRKADLRVHIKHMHTSDVPMTCRRCGQQLPDRYQYKLHVKSHEGEKCYSCKLCSYASVTQRHL 537
            ...:.:.|..| :.:||.:.|..|..||:..........|.:.|:|||.|.|..|..|......|
Mouse   476 RFVQSSHLIQH-QRIHTGEKPYVCDDCGRAFTQSSSLIYHQRIHKGEKPYKCSQCGKAFSMSTQL 539

  Fly   538 ASHMLIHLDEKPFHCDQCPQAFRQRQLLRRHMNLVHNEEYQPPEPREKLHKCPSCPREFTHKGNL 602
            .||...|..|:|:.|::|.:.|||...|.:| .::|        .|.|.::|..|.:.|:....|
Mouse   540 TSHQRTHTGERPYTCNECGKTFRQNSTLFQH-QIIH--------VRVKPYECNECGKAFSRSSYL 595

  Fly   603 MRHMETHDDSANARE 617
            :.|...|..:....|
Mouse   596 IEHQRIHTRAQGGHE 610

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CTCF	NP_648109.1	23ISL	<116..206	CDD:293226
		C2H2 Zn finger	296..316	CDD:275368	7/23 (30%)
		COG5048	321..>621	CDD:227381	101/349 (29%)
		zf-C2H2	322..344	CDD:278523	7/21 (33%)
		C2H2 Zn finger	324..344	CDD:275368	5/19 (26%)
		zf-H2C2_2	337..361	CDD:290200	9/23 (39%)
		C2H2 Zn finger	352..373	CDD:275368	8/20 (40%)
		C2H2 Zn finger	381..401	CDD:275368	7/19 (37%)
		zf-H2C2_2	394..415	CDD:290200	13/28 (46%)
		C2H2 Zn finger	409..429	CDD:275368	7/71 (10%)
		zf-H2C2_2	422..446	CDD:290200	12/23 (52%)
		C2H2 Zn finger	437..457	CDD:275368	5/19 (26%)
		C2H2 Zn finger	467..485	CDD:275368	4/17 (24%)
		C2H2 Zn finger	496..516	CDD:275370	4/19 (21%)
		C2H2 Zn finger	524..544	CDD:275368	6/19 (32%)
		zf-H2C2_2	536..561	CDD:290200	9/24 (38%)
		C2H2 Zn finger	552..573	CDD:275368	7/20 (35%)
		zf-C2H2	587..609	CDD:278523	5/21 (24%)
		C2H2 Zn finger	589..609	CDD:275368	5/19 (26%)
Zfp7	NP_001345745.1	KRAB	4..65	CDD:214630
		C2H2 Zn finger	194..214	CDD:275368
		C2H2 Zn finger	222..242	CDD:275368	6/18 (33%)
		COG5048	246..668	CDD:227381	110/382 (29%)
		C2H2 Zn finger	250..270	CDD:275368	7/23 (30%)
		C2H2 Zn finger	278..298	CDD:275368	5/19 (26%)
		C2H2 Zn finger	306..326	CDD:275368	8/20 (40%)
		C2H2 Zn finger	334..354	CDD:275368	7/19 (37%)
		C2H2 Zn finger	362..380	CDD:275368	4/17 (24%)
		C2H2 Zn finger	414..434	CDD:275368	3/19 (16%)
		C2H2 Zn finger	442..462	CDD:275368	5/19 (26%)
		C2H2 Zn finger	470..490	CDD:275368	4/20 (20%)
		C2H2 Zn finger	498..518	CDD:275368	4/19 (21%)
		C2H2 Zn finger	526..546	CDD:275368	6/19 (32%)
		C2H2 Zn finger	554..574	CDD:275368	7/20 (35%)
		C2H2 Zn finger	582..602	CDD:275368	5/19 (26%)
		C2H2 Zn finger	635..655	CDD:275368
		C2H2 Zn finger	663..683	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000