DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CTCF and ZNF585A

DIOPT Version :9

Sequence 1:	NP_648109.1	Gene:	CTCF / 38817	FlyBaseID:	FBgn0035769	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	NP_001275729.1	Gene:	ZNF585A / 199704	HGNCID:	26305	Length:	769	Species:	Homo sapiens

Alignment Length:	336	Identity:	115/336 - (34%)
Similarity:	157/336 - (46%)	Gaps:	25/336 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   284 SQNSNASGHK--------YSCPHC--PYTASKKFLITRHSRSHDVEPSFKCSICERSFRSNVGLQ 338
            |.|||...||        ..|..|  .:|...:.:|  |.|.|..|..::||.|.::|.....|.
Human   336 SNNSNLVTHKKVQSREKSSICTECGKAFTYRSELII--HQRIHTGEKPYECSDCGKAFTQKSALT 398

  Fly   339 NHINTHMGNKPHKCKLCESAFTTSGELVRHTRYKHTKEKPHKCTECTYASVELTKLRRHMTCHTG 403
            .|...|.|.|.:.|..|..||.....|:.| :..||.||||||..|.......::|..|...|||
Human   399 VHQRIHTGEKSYICMKCGLAFIQKAHLIAH-QIIHTGEKPHKCGHCGKLFTSKSQLHVHKRIHTG 462

  Fly   404 ERPYQCPHCTYASQDMFKLKRHMVIHTGEKKYQCDICKSRFTQSNSLKAHKLIHSVVDKPVFQCN 468
            |:||.|..|..|..:...|..|...|||||.|.|..|...|||.:.|..|:.||: .:|| ::||
Human   463 EKPYMCNKCGKAFTNRSNLITHQKTHTGEKSYICSKCGKAFTQRSDLITHQRIHT-GEKP-YECN 525

  Fly   469 YCPTTCGRKADLRVHIKHMHTSDVPMTCRRCGQQLPDRYQYKLHVKSHEGEKCYSCKLCSYASVT 533
            .|.....:|:.|.:|.| :||.:....|..||:....:....:|.|.|.|||.|.|..|..|.:.
Human   526 TCGKAFTQKSHLNIHQK-IHTGERQYECHECGKAFNQKSILIVHQKIHTGEKPYVCTECGRAFIR 589

  Fly   534 QRHLASHMLIHLDEKPFHCDQCPQAFRQRQLLRRHMNLVHNEEYQPPEPREKLHKCPSCPREFTH 598
            :.:..:|..||..|||:.|..|.::|..:..|     |||    ||....||.:.|..|.:.|:.
Human   590 KSNFITHQRIHTGEKPYECSDCGKSFTSKSQL-----LVH----QPVHTGEKPYVCAECGKAFSG 645

  Fly   599 KGNLMRHMETH 609
            :.||.:|.:||
Human   646 RSNLSKHQKTH 656

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CTCF	NP_648109.1	23ISL	<116..206	CDD:293226
		C2H2 Zn finger	296..316	CDD:275368	6/21 (29%)
		COG5048	321..>621	CDD:227381	101/289 (35%)
		zf-C2H2	322..344	CDD:278523	6/21 (29%)
		C2H2 Zn finger	324..344	CDD:275368	6/19 (32%)
		zf-H2C2_2	337..361	CDD:290200	9/23 (39%)
		C2H2 Zn finger	352..373	CDD:275368	6/20 (30%)
		C2H2 Zn finger	381..401	CDD:275368	4/19 (21%)
		zf-H2C2_2	394..415	CDD:290200	10/20 (50%)
		C2H2 Zn finger	409..429	CDD:275368	5/19 (26%)
		zf-H2C2_2	422..446	CDD:290200	11/23 (48%)
		C2H2 Zn finger	437..457	CDD:275368	7/19 (37%)
		C2H2 Zn finger	467..485	CDD:275368	6/17 (35%)
		C2H2 Zn finger	496..516	CDD:275370	5/19 (26%)
		C2H2 Zn finger	524..544	CDD:275368	4/19 (21%)
		zf-H2C2_2	536..561	CDD:290200	9/24 (38%)
		C2H2 Zn finger	552..573	CDD:275368	5/20 (25%)
		zf-C2H2	587..609	CDD:278523	6/21 (29%)
		C2H2 Zn finger	589..609	CDD:275368	6/19 (32%)
ZNF585A	NP_001275729.1	C2H2 Zn finger	748..768	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		KRAB	27..85	CDD:214630
		KRAB	27..66	CDD:279668
		C2H2 Zn finger	132..152	CDD:275368
		C2H2 Zn finger	160..180	CDD:275368
		COG5048	184..529	CDD:227381	71/197 (36%)
		C2H2 Zn finger	188..208	CDD:275368
		zf-H2C2_2	200..225	CDD:290200
		C2H2 Zn finger	216..236	CDD:275368
		C2H2 Zn finger	244..264	CDD:275368
		C2H2 Zn finger	272..292	CDD:275368
		zf-H2C2_2	284..309	CDD:290200
		C2H2 Zn finger	300..320	CDD:275368
		C2H2 Zn finger	328..347	CDD:275370	6/10 (60%)
		C2H2 Zn finger	356..376	CDD:275368	6/21 (29%)
		zf-H2C2_2	368..393	CDD:290200	9/26 (35%)
		C2H2 Zn finger	384..404	CDD:275368	6/19 (32%)
		C2H2 Zn finger	412..432	CDD:275368	6/20 (30%)
		C2H2 Zn finger	440..460	CDD:275368	4/19 (21%)
		zf-H2C2_2	455..477	CDD:290200	10/21 (48%)
		C2H2 Zn finger	468..488	CDD:275368	5/19 (26%)
		COG5048	476..768	CDD:227381	66/193 (34%)
		C2H2 Zn finger	496..516	CDD:275368	7/19 (37%)
		zf-H2C2_2	508..533	CDD:290200	9/26 (35%)
		C2H2 Zn finger	524..544	CDD:275368	7/20 (35%)
		zf-H2C2_2	536..561	CDD:290200	8/25 (32%)
		C2H2 Zn finger	552..572	CDD:275368	5/19 (26%)
		C2H2 Zn finger	580..600	CDD:275368	4/19 (21%)
		zf-H2C2_2	592..617	CDD:290200	9/24 (38%)
		C2H2 Zn finger	608..628	CDD:275368	9/28 (32%)
		C2H2 Zn finger	636..656	CDD:275368	6/19 (32%)
		zf-H2C2_2	648..673	CDD:290200	5/9 (56%)
		C2H2 Zn finger	664..684	CDD:275368
		zf-H2C2_2	676..700	CDD:290200
		C2H2 Zn finger	692..712	CDD:275368
		zf-H2C2_2	705..728	CDD:290200
		C2H2 Zn finger	720..740	CDD:275368
		zf-H2C2_2	732..757	CDD:290200
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910