DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CTCF and Zfp184

DIOPT Version :9

Sequence 1:	NP_648109.1	Gene:	CTCF / 38817	FlyBaseID:	FBgn0035769	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	NP_898835.1	Gene:	Zfp184 / 193452	MGIID:	1922244	Length:	737	Species:	Mus musculus

Alignment Length:	424	Identity:	133/424 - (31%)
Similarity:	194/424 - (45%)	Gaps:	47/424 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   201 MDLERELEELVDEPDISSMVTELSDYTVDEAAVE--AATATLTPNEAEVYEFEDNATTEDENADK 263
            ::|:...|.|..|       |.:::...|:.::|  .|...:.|.|.::  .|..|.|.:.|...
Mouse   112 LELDISEEHLFSE-------TVVTNSKRDDGSLEKLQANQQMLPREVQI--TEKTAPTCESNLSV 167

  Fly   264 KDVDFVLSNKEVKL---KTASSTSQNSNASGHK--YSCPHCPYTASKKFLITRHSRSHDVEPSFK 323
            .. .|: :..||.|   .|.:...|||:....:  ..|..|....:....:.||.|:|..|..:|
Mouse   168 SS-SFI-TQTEVALDQPSTKTRAKQNSHPVKKEKLCKCNECGKAFTYCSALIRHQRTHTGEKPYK 230

  Fly   324 CSICERSFRSNVGLQNHINTHMGNKPHKCKLCESAFTTSGELVRHTRYKHTKEKPHKCTECTYAS 388
            |:.|.::|..:..|.||...|.|:||:||..|...|.....|.:|.|. ||.|||:||.||..|.
Mouse   231 CNECNKAFSRSENLINHQRIHTGDKPYKCDQCGKGFIEGPSLTQHQRI-HTGEKPYKCDECGKAF 294

  Fly   389 VELTKLRRHMTCHTGERPYQCPHCTYASQDMFKLKRHMVIHTGEKKYQCDICKSRFTQSNSLKAH 453
            .:.|.|.:|...||||:||.|..|..:.........|..||||||.::|:.|:..||:|..|..|
Mouse   295 SQRTHLVQHQRIHTGEKPYTCTECGKSFSQRGHFMEHQKIHTGEKPFKCEECEKTFTRSTHLTQH 359

  Fly   454 KLIHSVVDKPVFQCNYC------PTTCGRKADLRVHIKH--MHTSDVPMTCRRCGQQLPDRYQYK 510
            :.||:  .:..::||.|      |:|         .|:|  :||.:.|..|..||:.........
Mouse   360 QKIHT--GEKTYKCNECGKAFNGPST---------FIRHHMIHTGEKPYECNECGKAFSQHSNLT 413

  Fly   511 LHVKSHEGEKCYSCKLCSYASVTQRHLASHMLIHLDEKPFHCDQCPQAFRQRQLLRRHMNLVHNE 575
            .|.|:|.|||.|.|..|..|......||.|:.||..|||:.|..|.:||.....|.:|.. :|.
Mouse   414 QHQKTHTGEKPYDCAECGKAFSYWSSLAQHLKIHTGEKPYKCSDCGKAFSYCSSLTQHRR-IHT- 476

  Fly   576 EYQPPEPREKLHKCPSCPREFTHKGNLMRHMETH 609
                   |||..:|..|.:.|::..||.:|.:||
Mouse   477 -------REKPFECSECGKAFSYLSNLNQHQKTH 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CTCF	NP_648109.1	23ISL	<116..206	CDD:293226	1/4 (25%)
		C2H2 Zn finger	296..316	CDD:275368	5/19 (26%)
		COG5048	321..>621	CDD:227381	104/297 (35%)
		zf-C2H2	322..344	CDD:278523	7/21 (33%)
		C2H2 Zn finger	324..344	CDD:275368	6/19 (32%)
		zf-H2C2_2	337..361	CDD:290200	11/23 (48%)
		C2H2 Zn finger	352..373	CDD:275368	6/20 (30%)
		C2H2 Zn finger	381..401	CDD:275368	7/19 (37%)
		zf-H2C2_2	394..415	CDD:290200	10/20 (50%)
		C2H2 Zn finger	409..429	CDD:275368	3/19 (16%)
		zf-H2C2_2	422..446	CDD:290200	10/23 (43%)
		C2H2 Zn finger	437..457	CDD:275368	7/19 (37%)
		C2H2 Zn finger	467..485	CDD:275368	5/23 (22%)
		C2H2 Zn finger	496..516	CDD:275370	5/19 (26%)
		C2H2 Zn finger	524..544	CDD:275368	6/19 (32%)
		zf-H2C2_2	536..561	CDD:290200	12/24 (50%)
		C2H2 Zn finger	552..573	CDD:275368	6/20 (30%)
		zf-C2H2	587..609	CDD:278523	6/21 (29%)
		C2H2 Zn finger	589..609	CDD:275368	6/19 (32%)
Zfp184	NP_898835.1	KRAB	28..88	CDD:214630
		COG5048	163..634	CDD:227381	120/364 (33%)
		C2H2 Zn finger	203..223	CDD:275368	5/19 (26%)
		C2H2 Zn finger	231..251	CDD:275368	6/19 (32%)
		C2H2 Zn finger	259..279	CDD:275368	6/20 (30%)
		C2H2 Zn finger	287..307	CDD:275368	7/19 (37%)
		C2H2 Zn finger	315..335	CDD:275368	3/19 (16%)
		C2H2 Zn finger	343..363	CDD:275368	7/19 (37%)
		C2H2 Zn finger	371..391	CDD:275368	7/28 (25%)
		C2H2 Zn finger	399..419	CDD:275368	5/19 (26%)
		C2H2 Zn finger	427..447	CDD:275368	6/19 (32%)
		C2H2 Zn finger	455..475	CDD:275368	6/20 (30%)
		C2H2 Zn finger	483..503	CDD:275368	6/19 (32%)
		C2H2 Zn finger	511..531	CDD:275368
		C2H2 Zn finger	539..559	CDD:275368
		C2H2 Zn finger	567..587	CDD:275368
		C2H2 Zn finger	595..615	CDD:275368
		C2H2 Zn finger	623..643	CDD:275368
		zf-H2C2_2	635..659	CDD:372612
		C2H2 Zn finger	651..671	CDD:275368
		C2H2 Zn finger	679..698	CDD:275368
		C2H2 Zn finger	706..726	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910