DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CTCF and Y5F2A.4

DIOPT Version :9

Sequence 1:	NP_648109.1	Gene:	CTCF / 38817	FlyBaseID:	FBgn0035769	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	NP_502063.1	Gene:	Y5F2A.4 / 178004	WormBaseID:	WBGene00012385	Length:	454	Species:	Caenorhabditis elegans

Alignment Length:	491	Identity:	111/491 - (22%)
Similarity:	176/491 - (35%)	Gaps:	128/491 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   293 KYSCPHCPYTASKKFLITRHS-RSH----------DVEPSFKCSICERSFRSNVGLQNHINTHMG 346
            ::.|..|..|...|..:|:|. |.|          ......|||:|::.|.....||.|..||:.
Worm     3 RHKCQDCGKTFDLKRYLTKHELRMHKNVVKSKNDRSASDPLKCSMCDKVFPRLSHLQRHQMTHLN 67

  Fly   347 NKPHKCKLCESAFTTSGELVRHTRYKHTKEKPHK-----CTECTYASVELTKLRRH-MTCHTGER 405
            .:.:.|..||..|.....|.||...||:.....:     |.:|........::|.| .|.|...:
Worm    68 VRNYSCTFCEEKFVQKSHLTRHVSRKHSNAPGVEVDWTACDKCGQLFKTTYEMRIHRQTYHELHK 132

  Fly   406 PYQCPHCTYASQDMFKLKRHMVIHTGEKKYQ--CDICKSRFTQSNSLKAHKLIHSVVDKPVFQCN 468
            ..||.....|..|  .|::|   |...:||.  ||.|.:.|::...|.:|:.  |.:.|..|.|.
Worm   133 CKQCQEVIEAGSD--GLRKH---HMQCRKYSNVCDECGASFSRPADLVSHET--SCLKKFAFVCK 190

  Fly   469 YCPTTCGRKADLRVHIK--HMHTSDVPMTCRRCGQQLPDRYQYKLHVKSHEGEKCYSCKLCSYAS 531
            .|.:...::..|..|||  |.|    |..|.:|.|......|...|  |.|..|...|..||..:
Worm   191 PCDSYFRQRVQLDRHIKKAHFH----PTKCSKCEQISDTPVQNSRH--SLECVKVIICGYCSLKN 249

  Fly   532 VTQRHLASHMLIHLDEKPFHCDQCPQAFRQRQLLRRHMNLVHNEEYQPPEPREKLHKCPSCPREF 596
            ..:.|:|:   :|     :|        |.::.:.:.:.:           |.||...|...::.
Worm   250 PDKNHVAT---VH-----WH--------RLKRAVSKSVTI-----------RHKLKDAPIADKDV 287

  Fly   597 -THKGNLMRHMETHDDSANARE------------KRRRLKLGRNVRLQKDGTVITLIKDQYVDMD 648
             :..|......|..|||.:..|            |.|.:|...|:...|..|           .:
Worm   288 PSSSGQSSLEEEILDDSEDDLEDTGEGLSNREQFKNRDIKRENNLEEVKSST-----------DN 341

  Fly   649 RDQEEN--------------------EEDDNPESYDLAEIEPENSEAEDADDDVETIVSDPIRQR 693
            ||:|::                    |:|..|..|....|.|:|::           :|..:|.|
Worm   342 RDEEDSLFNFPDTSTSQLDFCSTAFTEDDSFPGDYVTLSICPKNTD-----------LSFDLRDR 395

  Fly   694 IKP------------APIIINKQARLAASEKQPMII 717
            :.|            :.:::||..|...:.:.|:.|
Worm   396 LPPELSELFPELEATSIVLLNKSIRCRMTVRVPVCI 431

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CTCF	NP_648109.1	23ISL	<116..206	CDD:293226
		C2H2 Zn finger	296..316	CDD:275368	7/20 (35%)
		COG5048	321..>621	CDD:227381	79/322 (25%)
		zf-C2H2	322..344	CDD:278523	8/21 (38%)
		C2H2 Zn finger	324..344	CDD:275368	7/19 (37%)
		zf-H2C2_2	337..361	CDD:290200	9/23 (39%)
		C2H2 Zn finger	352..373	CDD:275368	7/20 (35%)
		C2H2 Zn finger	381..401	CDD:275368	5/20 (25%)
		zf-H2C2_2	394..415	CDD:290200	6/21 (29%)
		C2H2 Zn finger	409..429	CDD:275368	5/19 (26%)
		zf-H2C2_2	422..446	CDD:290200	9/25 (36%)
		C2H2 Zn finger	437..457	CDD:275368	6/19 (32%)
		C2H2 Zn finger	467..485	CDD:275368	4/17 (24%)
		C2H2 Zn finger	496..516	CDD:275370	5/19 (26%)
		C2H2 Zn finger	524..544	CDD:275368	5/19 (26%)
		zf-H2C2_2	536..561	CDD:290200	4/24 (17%)
		C2H2 Zn finger	552..573	CDD:275368	1/20 (5%)
		zf-C2H2	587..609	CDD:278523	3/22 (14%)
		C2H2 Zn finger	589..609	CDD:275368	3/20 (15%)
Y5F2A.4	NP_502063.1	C2H2 Zn finger	6..27	CDD:275368	7/20 (35%)
		zf-C2H2	44..65	CDD:278523	8/20 (40%)
		C2H2 Zn finger	45..65	CDD:275368	7/19 (37%)
		C2H2 Zn finger	73..94	CDD:275368	7/20 (35%)
		C2H2 Zn finger	107..126	CDD:275368	4/18 (22%)
		C2H2 Zn finger	161..181	CDD:275368	6/21 (29%)
		C2H2 Zn finger	189..212	CDD:275368	7/22 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	86	1.000	Inparanoid score	I3725
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050