DRSC/TRiP Functional Genomics Resources

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Protein Alignment CTCF and zfp-2

DIOPT Version :9

Sequence 1:NP_648109.1 Gene:CTCF / 38817 FlyBaseID:FBgn0035769 Length:818 Species:Drosophila melanogaster
Sequence 2:NP_496055.1 Gene:zfp-2 / 174505 WormBaseID:WBGene00009448 Length:422 Species:Caenorhabditis elegans


Alignment Length:461 Identity:93/461 - (20%)
Similarity:162/461 - (35%) Gaps:109/461 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   208 EELVDEPDISSMVTELSDYTVDEAAVEAATAT---LTPN---EAEVYEFEDNATTED---ENADK 263
            ||:...|::...:.:...:..::......|.|   .|||   :....:.|..:|::|   :...:
 Worm    17 EEVTTAPNLPCSLIQQRSWDEEKPIGYELTNTKCYKTPNGVQKTATIQREQLSTSKDFGEQQIVE 81

  Fly   264 KDVDFVLSNKEVKLKTASSTSQNSNASGHKYSCPHCPYTASKKFL-----ITRHSRSHDVEPSFK 323
            .|.:|.:...::.....:|:|...:.|.:..|..|.|....:..:     :.|          ||
 Worm    82 MDGEFSIEGTDMHAIPCTSSSMQPSTSSNPSSGEHQPVPLRRMAIKIGQRVLR----------FK 136

  Fly   324 CSICERSFRSNVGLQNH-INTHMGNKP----------HKCKLCESAFTTSGELVRHTRYKHTKEK 377
            ....|.:..:.:..|:. ||   ..||          ::|..|::.|.......||.:..|...:
 Worm   137 VISAEEAPEAPLDTQDSWIN---DPKPVTTPKALAGLYRCTNCKTYFGNKEVYQRHIQEVHGDAR 198

  Fly   378 PHKCTECTYASVELTKLRRHMTCHTGERP-YQCPHCTYASQDMFKLKRHMVIHTGEKKYQCDICK 441
            |.:|..|.......|.:..|:..|:..:| :.|.:|......:....||..:|.  .:..|..|.
 Worm   199 PFRCFNCGMRFANKTSMTHHLKDHSLLKPMFSCDYCPRIFSKLESKTRHHKMHF--TRSTCQTCM 261

  Fly   442 SRFTQSNSLKAHKLIHSVVDKPVF------------------QCNYCPTTCGRKADLRVHIKHMH 488
            ..||..::|:.|:   |......|                  .|:||        :||.|.|.  
 Worm   262 RFFTTEDALRHHQ---STAHPATFDSGPPPEDLLPNGKSARYSCSYC--------NLRFHFKK-- 313

  Fly   489 TSDVPMTCRRCGQQLPDRYQYKLHVKSHEGEKCYSCKLCSYASVTQRHLASHMLIHLDEKPFHCD 553
                               ...:|.:.|.|||.|||..|..:....:.|.:|:..|..|.|:.|.
 Worm   314 -------------------DMLVHERIHTGEKPYSCGYCMKSFAQSQALTAHIRTHTKELPYGCG 359

  Fly   554 QCPQAFRQRQLLRRHMNLVHNEEYQPPEPREKLHKCPSCPREFTHKGNLMRHMETHDDSANAREK 618
            :|.:.||....||:|....|.:|   |..|         |....:...:.:.|:      ..||.
 Worm   360 KCDKRFRDNSCLRKHELAAHTDE---PIVR---------PISVAYSNQVQKQMQ------RQREN 406

  Fly   619 RRRLKL 624
            ||:.:|
 Worm   407 RRKQEL 412

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CTCFNP_648109.1 23ISL <116..206 CDD:293226
C2H2 Zn finger 296..316 CDD:275368 3/24 (13%)
COG5048 321..>621 CDD:227381 71/329 (22%)
zf-C2H2 322..344 CDD:278523 6/22 (27%)
C2H2 Zn finger 324..344 CDD:275368 4/20 (20%)
zf-H2C2_2 337..361 CDD:290200 8/34 (24%)
C2H2 Zn finger 352..373 CDD:275368 5/20 (25%)
C2H2 Zn finger 381..401 CDD:275368 4/19 (21%)
zf-H2C2_2 394..415 CDD:290200 5/21 (24%)
C2H2 Zn finger 409..429 CDD:275368 4/19 (21%)
zf-H2C2_2 422..446 CDD:290200 6/23 (26%)
C2H2 Zn finger 437..457 CDD:275368 6/19 (32%)
C2H2 Zn finger 467..485 CDD:275368 6/17 (35%)
C2H2 Zn finger 496..516 CDD:275370 1/19 (5%)
C2H2 Zn finger 524..544 CDD:275368 4/19 (21%)
zf-H2C2_2 536..561 CDD:290200 8/24 (33%)
C2H2 Zn finger 552..573 CDD:275368 7/20 (35%)
zf-C2H2 587..609 CDD:278523 2/21 (10%)
C2H2 Zn finger 589..609 CDD:275368 2/19 (11%)
zfp-2NP_496055.1 C2H2 Zn finger 173..194 CDD:275368 5/20 (25%)
C2H2 Zn finger 202..222 CDD:275368 4/19 (21%)
C2H2 Zn finger 231..251 CDD:275368 4/19 (21%)
COG5048 <251..>358 CDD:227381 30/140 (21%)
C2H2 Zn finger 257..278 CDD:275368 7/23 (30%)
C2H2 Zn finger 302..322 CDD:275368 8/48 (17%)
C2H2 Zn finger 330..350 CDD:275368 4/19 (21%)
C2H2 Zn finger 358..374 CDD:275368 6/15 (40%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
00.000

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