DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CTCF and Zfp617

DIOPT Version :9

Sequence 1:	NP_648109.1	Gene:	CTCF / 38817	FlyBaseID:	FBgn0035769	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	NP_579936.2	Gene:	Zfp617 / 170938	MGIID:	2684459	Length:	559	Species:	Mus musculus

Alignment Length:	479	Identity:	137/479 - (28%)
Similarity:	201/479 - (41%)	Gaps:	66/479 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   191 KNP-------VIPKPEPMDLERELEELVDE-PD-ISSMVT-----ELSDYTVDEAAVEAATATLT 241
            |||       |:.|....:.:.:.||:..| || :.|..|     |...|..|.....:...:|.
Mouse    57 KNPGGNLRYQVVEKLCEYEEDSQWEEIFSEIPDPVVSQKTGEKPCESHVYGEDITGHSSLNVSLR 121

  Fly   242 -PNEAEVYEFEDNATTEDENADKKDVDFVLSNKEVKLKTASSTSQN---------------SNAS 290
             ....:.:|::::.   ::....||......:.:..||.....:|.               |:..
Mouse   122 GQTRCKTHEYKEHG---EKPCKCKDSGVAFGSPQSFLKHEQIYTQEKPYACKQCDKAFKYLSSLQ 183

  Fly   291 GHK--------YSCPHCPYTASKKFLITRHSRSHDVEPSFKCSICERSFRSNVGLQNHINTHMGN 347
            .||        ::|..|..:..::..:..|.|:|..|..:.|..|.:::.|...|:.|..:|.|.
Mouse   184 NHKRIHNRERNHACKQCGKSFKRQSNVQAHERNHTGEKPYVCKHCGKAYTSYSTLRAHERSHTGE 248

  Fly   348 KPHKCKLCESAFTTSGELVRHTRYKHTKEKPHKCTECTYASVELTKLRRHMTCHTGERPYQCPHC 412
            ||:.||.|..|:|:...|..|.| .||.|||:.|..|..|......||.|...||||:||.|.||
Mouse   249 KPYVCKHCGKAYTSYSTLRAHER-SHTGEKPYVCKHCGKAYTTYNTLRAHERSHTGEKPYVCKHC 312

  Fly   413 TYASQDMFKLKRHMVIHTGEKKYQCDICKSRFTQSNSLKAHKLIHSVVDKPVFQCNYCPTTCGRK 477
            ..|......|:.|...|||||.|.|..|...||||:.|:.||..|: .:|| :.|..|.....|.
Mouse   313 GKAYTSYSTLRAHERSHTGEKPYVCKHCGKAFTQSSYLRIHKRTHT-GEKP-YICKQCGKAFARS 375

  Fly   478 ADLRVHIKHMHTSDVPMTCRRCGQQLPDRYQYKLHVKSHEGEKCYSCKLCSYASVTQRHLASHML 542
            :.|::| |..||.:.|..|::||:.........:|.:||.|||.|.||.|..|.....||..|.:
Mouse   376 SHLQIH-KRSHTGEKPYVCKQCGKAFAQSSYLHIHQRSHTGEKPYVCKQCGKAFTRSSHLQIHKI 439

  Fly   543 IHLDEKPFHCDQCPQAFRQRQLLRRHMNLVHNEE--------------------YQPPEPREKLH 587
            .|..|||:.|..|.:||.....|:.|.. :|..|                    ::.....||.:
Mouse   440 THTGEKPYSCKLCGKAFTHSNYLQIHKR-IHTGEKPYVCKECGKAFARSTSLHIHEGTHSGEKPY 503

  Fly   588 KCPSCPREFTHKGNLMRHMETHDD 611
            .|..|.:.||...:|.||...|.:
Mouse   504 VCKQCGKAFTLSSSLRRHDVVHSE 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CTCF	NP_648109.1	23ISL	<116..206	CDD:293226	5/21 (24%)
		C2H2 Zn finger	296..316	CDD:275368	4/19 (21%)
		COG5048	321..>621	CDD:227381	106/311 (34%)
		zf-C2H2	322..344	CDD:278523	5/21 (24%)
		C2H2 Zn finger	324..344	CDD:275368	5/19 (26%)
		zf-H2C2_2	337..361	CDD:290200	10/23 (43%)
		C2H2 Zn finger	352..373	CDD:275368	8/20 (40%)
		C2H2 Zn finger	381..401	CDD:275368	6/19 (32%)
		zf-H2C2_2	394..415	CDD:290200	12/20 (60%)
		C2H2 Zn finger	409..429	CDD:275368	6/19 (32%)
		zf-H2C2_2	422..446	CDD:290200	11/23 (48%)
		C2H2 Zn finger	437..457	CDD:275368	9/19 (47%)
		C2H2 Zn finger	467..485	CDD:275368	5/17 (29%)
		C2H2 Zn finger	496..516	CDD:275370	4/19 (21%)
		C2H2 Zn finger	524..544	CDD:275368	7/19 (37%)
		zf-H2C2_2	536..561	CDD:290200	11/24 (46%)
		C2H2 Zn finger	552..573	CDD:275368	6/20 (30%)
		zf-C2H2	587..609	CDD:278523	7/21 (33%)
		C2H2 Zn finger	589..609	CDD:275368	7/19 (37%)
Zfp617	NP_579936.2	KRAB	4..>47	CDD:214630
		KRAB	4..40	CDD:279668
		C2H2 Zn finger	141..161	CDD:275368	4/19 (21%)
		COG5048	156..542	CDD:227381	117/377 (31%)
		C2H2 Zn finger	169..189	CDD:275368	3/19 (16%)
		C2H2 Zn finger	197..217	CDD:275368	4/19 (21%)
		zf-H2C2_2	209..234	CDD:290200	6/24 (25%)
		C2H2 Zn finger	225..245	CDD:275368	5/19 (26%)
		zf-H2C2_2	238..262	CDD:290200	10/23 (43%)
		C2H2 Zn finger	253..273	CDD:275368	8/20 (40%)
		zf-H2C2_2	266..290	CDD:290200	11/24 (46%)
		C2H2 Zn finger	281..301	CDD:275368	6/19 (32%)
		zf-H2C2_2	294..318	CDD:290200	13/23 (57%)
		C2H2 Zn finger	309..329	CDD:275368	6/19 (32%)
		zf-H2C2_2	322..346	CDD:290200	11/23 (48%)
		C2H2 Zn finger	337..357	CDD:275368	9/19 (47%)
		zf-H2C2_2	349..374	CDD:290200	8/26 (31%)
		C2H2 Zn finger	365..385	CDD:275368	6/20 (30%)
		zf-H2C2_2	377..402	CDD:290200	9/25 (36%)
		C2H2 Zn finger	393..413	CDD:275368	4/19 (21%)
		zf-H2C2_2	409..430	CDD:290200	11/20 (55%)
		C2H2 Zn finger	421..441	CDD:275368	7/19 (37%)
		zf-H2C2_2	433..458	CDD:290200	11/24 (46%)
		C2H2 Zn finger	449..469	CDD:275368	6/20 (30%)
		zf-H2C2_2	461..486	CDD:290200	4/25 (16%)
		C2H2 Zn finger	477..497	CDD:275368	0/19 (0%)
		C2H2 Zn finger	505..525	CDD:275368	7/19 (37%)
		C2H2 Zn finger	533..553	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000