DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CTCF and ZNF567

DIOPT Version :9

Sequence 1:	NP_648109.1	Gene:	CTCF / 38817	FlyBaseID:	FBgn0035769	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	NP_001374688.1	Gene:	ZNF567 / 163081	HGNCID:	28696	Length:	670	Species:	Homo sapiens

Alignment Length:	359	Identity:	116/359 - (32%)
Similarity:	165/359 - (45%)	Gaps:	27/359 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   273 KEVKLKTASSTSQNSNASGHKYSCPHCPYTASKKFLITRHSRSHDVEPSFKCSICERSFRSNVGL 337
            |..:||||.:..|.::.....|.|..|......|..:.||.|:|..|..::|:.|.:|||....|
Human   339 KSFRLKTALTDHQRTHTGEKSYECLQCRNAFRLKSHLIRHQRTHTGEKPYECNDCGKSFRQKTTL 403

  Fly   338 QNHINTHMGNKPHKCKLCESAFTTSGELVRHTRYKHTKEKPHKCTECTYASVELTKLRRHMTCHT 402
            ..|...|.|.||:.||.|..:|.....|..|.| .||.|||:.|.||..:..:.|.|..|...|.
Human   404 SLHQRIHTGEKPYICKECGKSFHQKANLTVHQR-THTGEKPYICNECGKSFSQKTTLALHEKTHN 467

  Fly   403 GERPYQCPHCTYASQDMFKLKRHMVIHTGEKKYQCDICKSRFTQSNSLKAHKLIHSVVDKPVFQC 467
            .|:||.|..|..:.:....|..|...|||||.|:|..|...|...:.|..|...|: .:|| ::|
Human   468 EEKPYICSECGKSFRQKTTLVAHQRTHTGEKSYECPHCGKAFRMKSYLIDHHRTHT-GEKP-YEC 530

  Fly   468 NYCPTTCGRKADLRVHIKHMHTSDVPMTCRRCGQQLPDRYQYKLHVKSHEGEKCYSCKLCSYASV 532
            |.|..:..:|.:|.:| :.:||.:.|..|..||:....:....:|.|.|.|:|.|.|..|..|..
Human   531 NECGKSFSQKTNLNLH-QRIHTGEKPYVCNECGKSFRQKATLTVHQKIHTGQKSYECPQCGKAFS 594

  Fly   533 TQRHLASHMLIHLDEKPFHCDQCPQAFRQRQLLRRHMNLVHNEEYQPPEPREKLHKCPSCPREFT 597
            .:.:|..|...|..|||:.|.:|.:.|||:..|     :||    |.....||.:.|..|.:.|:
Human   595 RKSYLIHHQRTHTGEKPYKCSECGKCFRQKTNL-----IVH----QRTHTGEKPYVCNECGKSFS 650

  Fly   598 HKGNLMRHMETHDDSANAREKRRRLKLGRNVRLQ 631
            :|.||:.|..||.              |.|:.:|
Human   651 YKRNLIVHQRTHK--------------GENIEMQ 670

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CTCF	NP_648109.1	23ISL	<116..206	CDD:293226
		C2H2 Zn finger	296..316	CDD:275368	6/19 (32%)
		COG5048	321..>621	CDD:227381	98/299 (33%)
		zf-C2H2	322..344	CDD:278523	7/21 (33%)
		C2H2 Zn finger	324..344	CDD:275368	7/19 (37%)
		zf-H2C2_2	337..361	CDD:290200	10/23 (43%)
		C2H2 Zn finger	352..373	CDD:275368	7/20 (35%)
		C2H2 Zn finger	381..401	CDD:275368	6/19 (32%)
		zf-H2C2_2	394..415	CDD:290200	8/20 (40%)
		C2H2 Zn finger	409..429	CDD:275368	4/19 (21%)
		zf-H2C2_2	422..446	CDD:290200	11/23 (48%)
		C2H2 Zn finger	437..457	CDD:275368	5/19 (26%)
		C2H2 Zn finger	467..485	CDD:275368	6/17 (35%)
		C2H2 Zn finger	496..516	CDD:275370	5/19 (26%)
		C2H2 Zn finger	524..544	CDD:275368	5/19 (26%)
		zf-H2C2_2	536..561	CDD:290200	9/24 (38%)
		C2H2 Zn finger	552..573	CDD:275368	6/20 (30%)
		zf-C2H2	587..609	CDD:278523	7/21 (33%)
		C2H2 Zn finger	589..609	CDD:275368	7/19 (37%)
ZNF567	NP_001374688.1	KRAB	6..89	CDD:214630
		C2H2 Zn finger	236..255	CDD:275368
		C2H2 Zn finger	278..298	CDD:275368
		COG5048	302..650	CDD:227381	106/323 (33%)
		C2H2 Zn finger	306..326	CDD:275368
		C2H2 Zn finger	334..354	CDD:275368	6/14 (43%)
		C2H2 Zn finger	362..382	CDD:275368	6/19 (32%)
		C2H2 Zn finger	390..410	CDD:275368	7/19 (37%)
		C2H2 Zn finger	418..438	CDD:275368	7/20 (35%)
		C2H2 Zn finger	446..466	CDD:275368	6/19 (32%)
		C2H2 Zn finger	474..494	CDD:275368	4/19 (21%)
		C2H2 Zn finger	502..522	CDD:275368	5/19 (26%)
		C2H2 Zn finger	530..550	CDD:275368	6/20 (30%)
		C2H2 Zn finger	558..578	CDD:275368	5/19 (26%)
		C2H2 Zn finger	586..606	CDD:275368	5/19 (26%)
		C2H2 Zn finger	614..634	CDD:275368	9/28 (32%)
		zf-C2H2	640..662	CDD:395048	7/21 (33%)
		C2H2 Zn finger	642..662	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910