DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CTCF and ZNF433

DIOPT Version :9

Sequence 1:	NP_648109.1	Gene:	CTCF / 38817	FlyBaseID:	FBgn0035769	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	XP_011526027.1	Gene:	ZNF433 / 163059	HGNCID:	20811	Length:	684	Species:	Homo sapiens

Alignment Length:	406	Identity:	116/406 - (28%)
Similarity:	171/406 - (42%)	Gaps:	70/406 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   290 SGHK-YSCPHCPYTASKKFLITRHSRSHDVEPSFKCSICERSFRSNVGLQNHINTHMGNKPHKCK 353
            :|.| |.|..|....|....:..|.|:|..|..:||:.|.::|.|:..|..|..||.|.||::||
Human   232 TGEKPYQCKQCGKAFSHSSSLRIHERTHTGEKPYKCNECGKAFHSSTCLHAHKRTHTGEKPYECK 296

  Fly   354 LCESAFTTSGELVRHTRYKHTKEKPHKCTECTYASVELTKLRRHMTCHTGERPYQCPHCTYASQD 418
            .|..||::|.....|.| .||.|||::|.||..|....:.:|||...|:.::||:|.||......
Human   297 QCGKAFSSSHSFQIHER-THTGEKPYECKECGKAFKCPSSVRRHERTHSRKKPYECKHCGKVLSY 360

  Fly   419 MFKLKRHMVIHTGEKKYQCDICKSRFTQSNSLKAHKLIHSVVDKPVFQCNYCPTTCGRKADLRVH 483
            :...:.|:.:||||..::|.||...|...:||:.|:..|: .:|| ::||.|.......:..|.|
Human   361 LTSFQNHLGMHTGEISHKCKICGKAFYSPSSLQTHEKTHT-GEKP-YKCNQCGKAFNSSSSFRYH 423

  Fly   484 IKHMHTSDVPMTCRRCGQQLPDRYQYKLHVKSHEGEKCYSCKLC--------------------- 527
             :..||.:.|..|::||:........:.|.::|.|||.|:||.|
Human   424 -ERTHTGEKPYECKQCGKAFRSASLLQTHGRTHTGEKPYACKECGKPFSNFSFFQIHERMHREEK 487

  Fly   528 -----------SYASVTQRHLASHM------------------------LIHLDEKPFHCDQCPQ 557
                       |..|:..||..:|.                        ..|..|||:.|.||.:
Human   488 PYECKGYGKTFSLPSLFHRHERTHTGGKTYECKQCGRSFNCSSSFRYHGRTHTGEKPYECKQCGK 552

  Fly   558 AFRQRQLLRRHMNLVHNEEYQPPEPREKLHKCPSCPREFTHKGNLMRHMETHDDSANAREKRRRL 622
            |||....|:     :|...:    ..||.::|..|.:.|....:|..|..||........|:...
Human   553 AFRSASQLQ-----IHGRTH----TGEKPYECKQCGKAFGSASHLQMHGRTHTGEKPYECKQCGK 608

  Fly   623 KLGRNVRLQKDGTVIT 638
            ..|...|||..|...|
Human   609 SFGCASRLQMHGRTHT 624

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CTCF	NP_648109.1	23ISL	<116..206	CDD:293226
		C2H2 Zn finger	296..316	CDD:275368	5/19 (26%)
		COG5048	321..>621	CDD:227381	100/355 (28%)
		zf-C2H2	322..344	CDD:278523	7/21 (33%)
		C2H2 Zn finger	324..344	CDD:275368	6/19 (32%)
		zf-H2C2_2	337..361	CDD:290200	12/23 (52%)
		C2H2 Zn finger	352..373	CDD:275368	8/20 (40%)
		C2H2 Zn finger	381..401	CDD:275368	7/19 (37%)
		zf-H2C2_2	394..415	CDD:290200	9/20 (45%)
		C2H2 Zn finger	409..429	CDD:275368	4/19 (21%)
		zf-H2C2_2	422..446	CDD:290200	9/23 (39%)
		C2H2 Zn finger	437..457	CDD:275368	7/19 (37%)
		C2H2 Zn finger	467..485	CDD:275368	5/17 (29%)
		C2H2 Zn finger	496..516	CDD:275370	4/19 (21%)
		C2H2 Zn finger	524..544	CDD:275368	8/75 (11%)
		zf-H2C2_2	536..561	CDD:290200	11/48 (23%)
		C2H2 Zn finger	552..573	CDD:275368	7/20 (35%)
		zf-C2H2	587..609	CDD:278523	5/21 (24%)
		C2H2 Zn finger	589..609	CDD:275368	5/19 (26%)
ZNF433	XP_011526027.1	KRAB	18..>60	CDD:214630
		KRAB	18..57	CDD:279668
		C2H2 Zn finger	145..175	CDD:275368
		C2H2 Zn finger	183..203	CDD:275368
		COG5048	208..614	CDD:227381	111/394 (28%)
		C2H2 Zn finger	211..231	CDD:275368
		zf-H2C2_2	227..248	CDD:290200	5/15 (33%)
		C2H2 Zn finger	239..259	CDD:275368	5/19 (26%)
		zf-H2C2_2	251..276	CDD:290200	8/24 (33%)
		C2H2 Zn finger	267..287	CDD:275368	6/19 (32%)
		zf-H2C2_2	283..304	CDD:290200	11/20 (55%)
		C2H2 Zn finger	295..315	CDD:275368	8/20 (40%)
		zf-H2C2_2	307..332	CDD:290200	11/25 (44%)
		C2H2 Zn finger	323..343	CDD:275368	7/19 (37%)
		C2H2 Zn finger	351..371	CDD:275368	4/19 (21%)
		C2H2 Zn finger	379..399	CDD:275368	7/19 (37%)
		zf-H2C2_2	391..416	CDD:290200	9/26 (35%)
		C2H2 Zn finger	407..427	CDD:275368	5/20 (25%)
		zf-H2C2_2	419..444	CDD:290200	8/25 (32%)
		C2H2 Zn finger	435..455	CDD:275368	4/19 (21%)
		C2H2 Zn finger	463..483	CDD:275368	3/19 (16%)
		C2H2 Zn finger	491..511	CDD:275368	4/19 (21%)
		C2H2 Zn finger	519..539	CDD:275368	0/19 (0%)
		C2H2 Zn finger	547..567	CDD:275368	8/24 (33%)
		C2H2 Zn finger	575..595	CDD:275368	5/19 (26%)
		C2H2 Zn finger	603..623	CDD:275368	6/19 (32%)
		C2H2 Zn finger	631..651	CDD:275368
		zf-H2C2_2	643..668	CDD:290200
		C2H2 Zn finger	659..679	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000