DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CTCF and ZNF524

DIOPT Version :9

Sequence 1:NP_648109.1 Gene:CTCF / 38817 FlyBaseID:FBgn0035769 Length:818 Species:Drosophila melanogaster
Sequence 2:XP_011524789.1 Gene:ZNF524 / 147807 HGNCID:28322 Length:370 Species:Homo sapiens


Alignment Length:337 Identity:79/337 - (23%)
Similarity:112/337 - (33%) Gaps:103/337 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   117 GKATRSVVSTATNKSINLRPAKSTPKATTSKPPPEPKAISVRPARAAAAKAKQSAMPPPPALVVK 181
            |||.|:..|..|          ..|..:...|.|:|     .|:.....:.|..|:.|       
Human    89 GKAFRAGSSAQT----------QAPHCSMDTPSPDP-----LPSPLPGEEEKPLALSP------- 131

  Fly   182 VPAPRGRPRKNPVIPKPEPMDLERELEELVDEPDISSMVTELSDYTVDEAAVEAATATLTPNEAE 246
             |.||||..:.|.........|:..|......|..|.....|       ..|:..||.:..:.. 
Human   132 -PVPRGRRGRRPGGATSSNRTLKASLPRKRGRPPKSGQEPPL-------VQVQGVTAPVGSSGG- 187

  Fly   247 VYEFEDNATTEDENADKKDVDFVLSNKEVKLKTASSTSQNSNASGHKYSCPHCPYTASKKFLITR 311
                .|....:|:..                                      |||.|:......
Human   188 ----SDLLLIDDQGV--------------------------------------PYTVSEGSAAGP 210

  Fly   312 HSRSHDVEPSFKCSICERSFRSNVGLQNHINTHMGNKPHKCKLCESAFTTSGELVRHTRYKHTKE 376
            ........|.| |.:|.|:|.....|:.|..:|...|||:||:|...|               |.
Human   211 EGSGPRKAPHF-CPVCLRAFPYLSDLERHSISHSELKPHQCKVCGKTF---------------KR 259

  Fly   377 KPHKCTECTYASVELTKLRRHMTCHTGERPYQCPHCTYASQDMFKLKRHMVIHTGEKKYQCDICK 441
            ..|              ||||...|.|.||::||.|....::..:|..|..:|:||:.|||.||:
Human   260 SSH--------------LRRHCNIHAGLRPFRCPLCPRRFREAGELAHHHRVHSGERPYQCPICR 310

  Fly   442 SRFTQSNSLKAH 453
            .|||::|:|:.|
Human   311 LRFTEANTLRRH 322

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CTCFNP_648109.1 23ISL <116..206 CDD:293226 21/88 (24%)
C2H2 Zn finger 296..316 CDD:275368 4/19 (21%)
COG5048 321..>621 CDD:227381 44/133 (33%)
zf-C2H2 322..344 CDD:278523 7/21 (33%)
C2H2 Zn finger 324..344 CDD:275368 6/19 (32%)
zf-H2C2_2 337..361 CDD:290200 10/23 (43%)
C2H2 Zn finger 352..373 CDD:275368 4/20 (20%)
C2H2 Zn finger 381..401 CDD:275368 4/19 (21%)
zf-H2C2_2 394..415 CDD:290200 11/20 (55%)
C2H2 Zn finger 409..429 CDD:275368 5/19 (26%)
zf-H2C2_2 422..446 CDD:290200 12/23 (52%)
C2H2 Zn finger 437..457 CDD:275368 9/17 (53%)
C2H2 Zn finger 467..485 CDD:275368
C2H2 Zn finger 496..516 CDD:275370
C2H2 Zn finger 524..544 CDD:275368
zf-H2C2_2 536..561 CDD:290200
C2H2 Zn finger 552..573 CDD:275368
zf-C2H2 587..609 CDD:278523
C2H2 Zn finger 589..609 CDD:275368
ZNF524XP_011524789.1 COG5048 <219..>283 CDD:227381 29/93 (31%)
C2H2 Zn finger 222..242 CDD:275368 6/19 (32%)
zf-H2C2_2 234..259 CDD:290200 10/39 (26%)
C2H2 Zn finger 250..270 CDD:275368 10/48 (21%)
zf-H2C2_2 262..285 CDD:290200 12/36 (33%)
C2H2 Zn finger 278..298 CDD:275368 5/19 (26%)
zf-H2C2_2 290..314 CDD:290200 11/23 (48%)
C2H2 Zn finger 306..327 CDD:275368 9/17 (53%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24390
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.100

Return to query results.
Submit another query.