DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CTCF and ZNF534

DIOPT Version :9

Sequence 1:	NP_648109.1	Gene:	CTCF / 38817	FlyBaseID:	FBgn0035769	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	NP_001137411.1	Gene:	ZNF534 / 147658	HGNCID:	26337	Length:	674	Species:	Homo sapiens

Alignment Length:	470	Identity:	134/470 - (28%)
Similarity:	192/470 - (40%)	Gaps:	73/470 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   238 ATLTPNEAEVYEFEDNATTEDENADKKDVDFVLSNKEVKLKTASST----------SQNSNASGH 292
            :||.|.|.:|: ..:.....:|:.....|...|:|::| :..|..|          |.|||.:.|
Human   183 STLLPQEQKVH-IREKPYGCNEHGKVFRVSSSLTNRQV-IHIADKTYKCSDCGEIFSSNSNFAQH 245

  Fly   293 K------------------------------------YSCPHCPYTASKKFLITRHSRSHDVEPS 321
            :                                    |:...|....|....:.:|.:.|..|..
Human   246 QRIHTGEKPYKYNECGKVFNQNSHLAQHQKIHTGQKPYNNKECGKVFSHHAYLAQHRKIHTGEKP 310

  Fly   322 FKCSICERSFRSNVGLQNHINTHMGNKPHKCKLCESAFTTSGELVRHTRYKHTKEKPHKCTECTY 386
            :|||.|.::|.....|..|:..|.|.||:.||.|...|.....|..| :..||.|:|:||.||..
Human   311 YKCSECGKAFSVCSSLTAHLVIHTGEKPYDCKECGKVFRHKSSLTTH-QTVHTGERPYKCNECGK 374

  Fly   387 ASVELTKLRRHMTCHTGERPYQCPHCTYASQDMFKLKRHMVIHTGEKKYQCDICKSRFTQSNSLK 451
            ....:..|.||...||||:||:|..|........:|.||..||||.::|:|:.|...|...:.|.
Human   375 GFSRIAFLARHRKVHTGEKPYKCNECGKVFIGNSRLARHRKIHTGGRRYKCNECGKAFRTCSDLT 439

  Fly   452 AHKLIHSVVDKPVFQCNYCPTTCGRKADLRVHIKHMHTSDVPMTCRRCGQQLPDRYQYKLHVKSH 516
            ||.|||: .:|| ::|..|......|:.|..|.: :||.:.|..|..||:........:.|.|.|
Human   440 AHLLIHT-GEKP-YECIDCGKVFRHKSSLTYHCR-IHTGEKPYKCNECGKVFSQNSNLQRHRKIH 501

  Fly   517 EGEKCYSCKLCSYASVTQRHLASHMLIHLDEKPFHCDQCPQAFRQRQLLRRHMNLVHNEE----- 576
            .|||.|.|..|........|||.|..||..|||:.|::|.:.||:...|.||.| ||..|
Human   502 TGEKLYKCNECGKVFRQNSHLAQHRDIHTGEKPYSCNECGKVFRRNSHLVRHRN-VHTGEKPYSC 565

  Fly   577 ---------------YQPPEPREKLHKCPSCPREFTHKGNLMRHMETHDDSANAREKRRRLKLGR 626
                           ::.....||.|.|..|.:.|:...:|.||.:.|......:.........|
Human   566 NECGKVFSRNSHLARHRNIHTGEKPHSCNECGKVFSRNSHLARHRKIHTGEKLYKCNECSKVFSR 630

  Fly   627 NVRLQKDGTVITLIK 641
            |.||.:...:.|.:|
Human   631 NSRLAQHRNIHTGVK 645

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CTCF	NP_648109.1	23ISL	<116..206	CDD:293226
		C2H2 Zn finger	296..316	CDD:275368	3/19 (16%)
		COG5048	321..>621	CDD:227381	105/319 (33%)
		zf-C2H2	322..344	CDD:278523	7/21 (33%)
		C2H2 Zn finger	324..344	CDD:275368	6/19 (32%)
		zf-H2C2_2	337..361	CDD:290200	10/23 (43%)
		C2H2 Zn finger	352..373	CDD:275368	6/20 (30%)
		C2H2 Zn finger	381..401	CDD:275368	6/19 (32%)
		zf-H2C2_2	394..415	CDD:290200	11/20 (55%)
		C2H2 Zn finger	409..429	CDD:275368	5/19 (26%)
		zf-H2C2_2	422..446	CDD:290200	11/23 (48%)
		C2H2 Zn finger	437..457	CDD:275368	7/19 (37%)
		C2H2 Zn finger	467..485	CDD:275368	5/17 (29%)
		C2H2 Zn finger	496..516	CDD:275370	5/19 (26%)
		C2H2 Zn finger	524..544	CDD:275368	6/19 (32%)
		zf-H2C2_2	536..561	CDD:290200	12/24 (50%)
		C2H2 Zn finger	552..573	CDD:275368	8/20 (40%)
		zf-C2H2	587..609	CDD:278523	7/21 (33%)
		C2H2 Zn finger	589..609	CDD:275368	6/19 (32%)
ZNF534	NP_001137411.1	KRAB	8..81	CDD:214630
		KRAB	8..47	CDD:279668
		C2H2 Zn finger	201..221	CDD:275368	5/20 (25%)
		COG5048	211..609	CDD:227381	118/403 (29%)
		C2H2 Zn finger	229..249	CDD:275368	5/19 (26%)
		zf-H2C2_2	241..266	CDD:290200	2/24 (8%)
		C2H2 Zn finger	258..277	CDD:275368	0/18 (0%)
		C2H2 Zn finger	286..305	CDD:275368	3/18 (17%)
		zf-H2C2_2	297..321	CDD:290200	7/23 (30%)
		C2H2 Zn finger	313..333	CDD:275368	6/19 (32%)
		C2H2 Zn finger	341..361	CDD:275368	6/20 (30%)
		zf-H2C2_2	353..378	CDD:290200	10/25 (40%)
		C2H2 Zn finger	369..389	CDD:275368	6/19 (32%)
		zf-H2C2_2	382..404	CDD:290200	11/21 (52%)
		C2H2 Zn finger	397..417	CDD:275368	5/19 (26%)
		C2H2 Zn finger	425..445	CDD:275368	7/19 (37%)
		C2H2 Zn finger	453..473	CDD:275368	5/20 (25%)
		zf-H2C2_2	465..490	CDD:290200	8/25 (32%)
		C2H2 Zn finger	481..501	CDD:275368	5/19 (26%)
		zf-H2C2_2	493..518	CDD:290200	9/24 (38%)
		C2H2 Zn finger	509..529	CDD:275368	6/19 (32%)
		zf-H2C2_2	521..546	CDD:290200	12/24 (50%)
		C2H2 Zn finger	537..557	CDD:275368	8/20 (40%)
		zf-H2C2_2	549..574	CDD:290200	7/25 (28%)
		C2H2 Zn finger	565..585	CDD:275368	0/19 (0%)
		zf-H2C2_2	577..602	CDD:290200	6/24 (25%)
		C2H2 Zn finger	593..613	CDD:275368	6/19 (32%)
		zf-H2C2_2	605..630	CDD:290200	4/24 (17%)
		C2H2 Zn finger	621..641	CDD:275368	4/19 (21%)
		C2H2 Zn finger	649..669	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000