DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CTCF and CTCFL

DIOPT Version :10

Sequence 1:NP_648109.1 Gene:CTCF / 38817 FlyBaseID:FBgn0035769 Length:818 Species:Drosophila melanogaster
Sequence 2:NP_001255972.1 Gene:CTCFL / 140690 HGNCID:16234 Length:700 Species:Homo sapiens


Alignment Length:763 Identity:219/763 - (28%)
Similarity:340/763 - (44%) Gaps:140/763 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    36 TILEAISAEAIDLDENGAEAGGSKPMEEAEAD-----LDHAEEAEEEEEDDEDKYFIDDEGNCYI 95
            |.:..:|.:...:.|  .|....|.::|.|.|     .||...:|.|.|                
Human     4 TEISVLSEQFTKIKE--LELMPEKGLKEEEKDGVCREKDHRSPSELEAE---------------- 50

  Fly    96 KTTPKKQKELQKKLKQAAAKPGKATRSVVSTA-----TNKSINLRPAKSTPKATTSKPPPEPKAI 155
            :|:...|..:.::..:....|.:.:...:.|.     |::::.|:               :...:
Human    51 RTSGAFQDSVLEEEVELVLAPSEESEKYILTLQTVHFTSEAVELQ---------------DMSLL 100

  Fly   156 SVRPARAAAAKAKQSAMPPPPALVVKVPAPRGRPRKNPVIPKPE----PMDLE----RELEE--- 209
            |::.........:|    |.|.|:.....||...::...|...:    |.::|    ..|||   
Human   101 SIQQQEGVQVVVQQ----PGPGLLWLEEGPRQSLQQCVAISIQQELYSPQEMEVLQFHALEENVM 161

  Fly   210 --------------------LVDEPDISSMVTE--------LSDYTVDEAAVEAATATLTPNEAE 246
                                |.:|.:.:.::.|        :...:.||.:.|   ..||.:.:.
Human   162 VASEDSKLAVSLAETTGLIKLEEEQEKNQLLAERTKEQLFFVETMSGDERSDE---IVLTVSNSN 223

  Fly   247 VYEFEDNATTEDENADKKDVDFVLSNKEVKLKTASSTSQNSNASGHK--YSCPHCPYTASKKFLI 309
            |.|.||..|....:|:|                |.||.......|.|  :.|..|.:|:|:....
Human   224 VEEQEDQPTAGQADAEK----------------AKSTKNQRKTKGAKGTFHCDVCMFTSSRMSSF 272

  Fly   310 TRHSRSHDVEPSFKCSICERSFRSNVGLQNHINTHMGNKPHKCKLCESAFTTSGELVRHTRYKHT 374
            .||.::|..|....|.:|.::||:...|:||:|||.|.:|:||..|..||.||||||||.|||||
Human   273 NRHMKTHTSEKPHLCHLCLKTFRTVTLLRNHVNTHTGTRPYKCNDCNMAFVTSGELVRHRRYKHT 337

  Fly   375 KEKPHKCTECTYASVELTKLRRHMTCHTGERPYQCPHCTYASQDMFKLKRHMVIHTGEKKYQCDI 439
            .|||.||:.|.|||||.:||:||:..||||||:||..|:|||:|.:||||||..|:|||.|:|.|
Human   338 HEKPFKCSMCKYASVEASKLKRHVRSHTGERPFQCCQCSYASRDTYKLKRHMRTHSGEKPYECHI 402

  Fly   440 CKSRFTQSNSLKAHKLIHSVVDKPVFQCNYCPTTCGRKADLRVHIKHMHT-SDVPMTCRRCGQQL 503
            |.:|||||.::|.|.|.....:.|.:||.:|.|...||:|||||::::|. |...:.||.|....
Human   403 CHTRFTQSGTMKIHILQKHGENVPKYQCPHCATIIARKSDLRVHMRNLHAYSAAELKCRYCSAVF 467

  Fly   504 PDRYQYKLHVKSHEGEKCYSCKLCSYASVTQRHLASHMLIHLDEKPFHCDQCPQAFRQRQLLRRH 568
            .:||....|.|:|:.||.:.||.||||...:||:.:|:..|..||||.|..|.:.|||:|||..|
Human   468 HERYALIQHQKTHKNEKRFKCKHCSYACKQERHMTAHIRTHTGEKPFTCLSCNKCFRQKQLLNAH 532

  Fly   569 MNLVHNEEYQPPEPREKLHKCPSCPREFTHKGNLMRHMETHDDSANAREKRRRLKLGRNVRLQKD 633
            ....|:..:.|     .::||..|.:.|:...||.||.|   ...:...|......||..|.:|.
Human   533 FRKYHDANFIP-----TVYKCSKCGKGFSRWINLHRHSE---KCGSGEAKSAASGKGRRTRKRKQ 589

  Fly   634 GTVITLIKDQYVDMDRDQEENEEDDNPESYDLAEIEPENSEAEDADDDVETIVSDPIRQRIK--- 695
                |::|:.........:..:|..|.:  :.|..|...::.|....::..:.......|:|   
Human   590 ----TILKEATKGQKEAAKGWKEAANGD--EAAAEEASTTKGEQFPGEMFPVACRETTARVKEEV 648

  Fly   696 ----PAPIIINKQARLAASEKQPMIINQRL-----------RSQRGTK 728
                ...:::|.....|....:.|:::..|           |.:||::
Human   649 DEGVTCEMLLNTMDNSAGCTGRMMLVSAWLLGRPQETYNQGRRRRGSR 696

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CTCFNP_648109.1 FAP 116..>202 CDD:429334 13/94 (14%)
C2H2 Zn finger 296..316 CDD:275368 6/19 (32%)
COG5048 321..>621 CDD:227381 139/300 (46%)
C2H2 Zn finger 324..344 CDD:275368 8/19 (42%)
C2H2 Zn finger 352..373 CDD:275368 14/20 (70%)
C2H2 Zn finger 381..401 CDD:275368 11/19 (58%)
zf-H2C2_2 394..415 CDD:463886 12/20 (60%)
C2H2 Zn finger 409..429 CDD:275368 12/19 (63%)
zf-H2C2_2 422..446 CDD:463886 15/23 (65%)
C2H2 Zn finger 437..457 CDD:275368 11/19 (58%)
C2H2 Zn finger 467..485 CDD:275368 10/17 (59%)
C2H2 Zn finger 496..516 CDD:275370 7/19 (37%)
C2H2 Zn finger 524..544 CDD:275368 9/19 (47%)
zf-H2C2_2 536..561 CDD:463886 10/24 (42%)
C2H2 Zn finger 552..573 CDD:275368 9/20 (45%)
zf-C2H2 587..609 CDD:395048 9/21 (43%)
C2H2 Zn finger 589..609 CDD:275368 8/19 (42%)
CTCFLNP_001255972.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 24..55 10/46 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 221..250 10/44 (23%)
COG5048 <259..403 CDD:227381 78/143 (55%)
C2H2 Zn finger 259..279 CDD:275368 6/19 (32%)
C2H2 Zn finger 287..307 CDD:275368 8/19 (42%)
C2H2 Zn finger 315..333 CDD:275368 12/17 (71%)
C2H2 Zn finger 344..364 CDD:275368 11/19 (58%)
C2H2 Zn finger 372..392 CDD:275368 12/19 (63%)
SUF4-like <392..>432 CDD:411020 19/39 (49%)
C2H2 Zn finger 400..421 CDD:411020 11/20 (55%)
C2H2 Zn finger 400..417 CDD:275368 9/16 (56%)
C2H2 Zn finger 430..448 CDD:275368 10/17 (59%)
SUF4-like 459..>492 CDD:411020 12/32 (38%)
C2H2 Zn finger 460..485 CDD:411020 9/24 (38%)
C2H2 Zn finger 460..480 CDD:275368 7/19 (37%)
C2H2 Zn finger 488..508 CDD:275368 9/19 (47%)
C2H2 Zn finger 516..534 CDD:275368 9/17 (53%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 569..630 12/66 (18%)

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