DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CTCF and Ctcfl

DIOPT Version :9

Sequence 1:	NP_648109.1	Gene:	CTCF / 38817	FlyBaseID:	FBgn0035769	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	NP_001309415.1	Gene:	Ctcfl / 100360757	RGDID:	2321501	Length:	645	Species:	Rattus norvegicus

Alignment Length:	683	Identity:	218/683 - (31%)
Similarity:	308/683 - (45%)	Gaps:	145/683 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 DLDENGAEAGGSKPMEEAEADLDHAEEAEEEEEDDEDKYFIDDEGNCYIKTTPKKQKELQKKLKQ 111
            ||:|...|.|    ::..||.....||||.|.:                        ||..:
  Rat    25 DLEEEKEEGG----VQRGEAQEGAVEEAEAEPQ------------------------ELPSR--- 58

  Fly   112 AAAKPGKATRSVVST----ATNKSINLRPAKSTPKATTSKPPPEPKAISVRPARAAAAKAKQSAM 172
               .|.::.|.:::.    .|::.::|:..     ...|.|..|..:::|..|.:.........:
  Rat    59 ---APVESDRRILTLQTLHLTSQDVHLQGL-----GWLSVPHSEELSMTVPQAESILQLPSVLWL 115

  Fly   173 PPPPAL------VVKVPAPRGRPRKNPVIPKPEPMDLE--RELEELVDEPDISSMVTELSDYTVD 229
            .|.|.|      .|.:|        ..:.| ||.::|.  ..|.|.|.|.|     .|..:.|
  Rat   116 DPEPPLSLQHCVTVSIP--------EELYP-PEMLELRHFHLLRENVPEDD-----EENQEST-- 164

  Fly   230 EAAVEAATATLTPNEAEVYEFEDNATTEDENADKKDVDFVL------SNKEVKLKTASSTS---- 284
             :.:|.:||...|.|.|..:......|     |||:..|:.      ..|:..:.|.|..|
  Rat   165 -SNLEESTAPKKPEEDEKDQLLPQGGT-----DKKEERFLFVEMKPREGKDEIVLTISHLSLEEQ 223

  Fly   285 ------QNSNASGHK----------------YSCPHCPYTASKKFLITRHSRSHDVEPSFKCSIC 327
                  ::::|.|.|                :.|..||:|:||.....||.:.|..|....|.:|
  Rat   224 QDPPAAKHTSAPGAKAAKPKPQRQTKGRPRTFQCDTCPFTSSKLSTFNRHIKIHSDERPHLCHLC 288

  Fly   328 ERSFRSNVGLQNHINTHMGNKPHKCKLCESAFTTSGELVRHTRYKHTKEKPHKCTECTYASVELT 392
            .:|||:...|:||:|||.|.:|:||..|:.||.||||||||.|||||.|||.||:.|.|||||.:
  Rat   289 LKSFRTVTLLRNHVNTHTGTRPYKCGDCDMAFVTSGELVRHRRYKHTHEKPFKCSLCKYASVEAS 353

  Fly   393 KLRRHMTCHTGERPYQCPHCTYASQDMFKLKRHMVIHTGEKKYQCDICKSRFTQSNSLKAHKLIH 457
            ||:||:..||||||:||..|.|||:|.:||||||..|:|||.|:|..|.:|||||.::|.|....
  Rat   354 KLKRHIRSHTGERPFQCSQCAYASKDTYKLKRHMRTHSGEKPYECPTCHARFTQSGTMKIHIAQK 418

  Fly   458 SVVDKPVFQCNYCPTTCGRKADLRVHIKHMH-TSDVPMTCRRCGQQLPDRYQYKLHVKSHEGEKC 521
            ...:.|..:|.:|.|...||:|||||::::| .|...:.||.|.....:||....|.::|:.||.
  Rat   419 HGENVPKHECPHCATIIARKSDLRVHLRNLHGHSPEEIKCRYCPAAFHERYALLQHQRTHKNEKK 483

  Fly   522 YSCKLCSYASVTQRHLASHMLIHLDEKPFHCDQCPQAFRQRQLLRRHMNLVHNEEYQPPEPREKL 586
            :.||.|.||...:|.|.:||..|..|:||.|..|.:.|||:|||..|:...|:..:.|     .:
  Rat   484 FKCKQCDYACKQERCLTAHMRTHTGERPFSCLTCNKHFRQKQLLTVHLRKYHDPSFVP-----SV 543

  Fly   587 HKCPSCPREFTHKGNLMRHME----THDDSANAREKRRRLKLGRNV-RLQKDGTVITLIKDQYVD 646
            |.|..|.:.|:...||.||.:    .|:.||.:|.       ||.| |.|.
  Rat   544 HLCLKCGKGFSRWSNLQRHRKKCDPEHEKSAPSRN-------GRPVTRAQA-------------- 587

  Fly   647 MDRDQEENEEDD----NPESYDLAEIEPENSEA 675
                .||..|.|    ..||....|..|...:|
  Rat   588 ----SEEGAEHDKDVATQESATSGEPRPPEEQA 616

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CTCF	NP_648109.1	23ISL	<116..206	CDD:293226	18/101 (18%)
		C2H2 Zn finger	296..316	CDD:275368	8/19 (42%)
		COG5048	321..>621	CDD:227381	137/304 (45%)
		zf-C2H2	322..344	CDD:278523	9/21 (43%)
		C2H2 Zn finger	324..344	CDD:275368	9/19 (47%)
		zf-H2C2_2	337..361	CDD:290200	13/23 (57%)
		C2H2 Zn finger	352..373	CDD:275368	14/20 (70%)
		C2H2 Zn finger	381..401	CDD:275368	11/19 (58%)
		zf-H2C2_2	394..415	CDD:290200	12/20 (60%)
		C2H2 Zn finger	409..429	CDD:275368	12/19 (63%)
		zf-H2C2_2	422..446	CDD:290200	14/23 (61%)
		C2H2 Zn finger	437..457	CDD:275368	9/19 (47%)
		C2H2 Zn finger	467..485	CDD:275368	10/17 (59%)
		C2H2 Zn finger	496..516	CDD:275370	6/19 (32%)
		C2H2 Zn finger	524..544	CDD:275368	9/19 (47%)
		zf-H2C2_2	536..561	CDD:290200	10/24 (42%)
		C2H2 Zn finger	552..573	CDD:275368	9/20 (45%)
		zf-C2H2	587..609	CDD:278523	8/25 (32%)
		C2H2 Zn finger	589..609	CDD:275368	7/23 (30%)
Ctcfl	NP_001309415.1	C2H2 Zn finger	257..277	CDD:275368	8/19 (42%)
		C2H2 Zn finger	285..305	CDD:275368	9/19 (47%)
		zf-H2C2_2	298..322	CDD:290200	13/23 (57%)
		C2H2 Zn finger	313..334	CDD:275368	14/20 (70%)
		COG5048	336..>398	CDD:227381	39/61 (64%)
		C2H2 Zn finger	342..362	CDD:275368	11/19 (58%)
		zf-H2C2_2	355..378	CDD:290200	14/22 (64%)
		C2H2 Zn finger	370..390	CDD:275368	12/19 (63%)
		zf-H2C2_2	383..407	CDD:290200	14/23 (61%)
		C2H2 Zn finger	398..415	CDD:275370	8/16 (50%)
		C2H2 Zn finger	428..451	CDD:275368	11/22 (50%)
		C2H2 Zn finger	458..478	CDD:275368	6/19 (32%)
		zf-H2C2_2	470..495	CDD:290200	9/24 (38%)
		C2H2 Zn finger	486..506	CDD:275368	9/19 (47%)
		zf-H2C2_2	499..523	CDD:290200	10/23 (43%)
		C2H2 Zn finger	514..532	CDD:275368	9/17 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BAC7
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	320	1.000	Inparanoid score	I2442
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm44416
orthoMCL	1	0.900	-	-		OOG6_107263
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.720