DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CTCF and Zfp958

DIOPT Version :9

Sequence 1:	NP_648109.1	Gene:	CTCF / 38817	FlyBaseID:	FBgn0035769	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	XP_038944925.1	Gene:	Zfp958 / 100302405	RGDID:	2311392	Length:	495	Species:	Rattus norvegicus

Alignment Length:	372	Identity:	119/372 - (31%)
Similarity:	167/372 - (44%)	Gaps:	60/372 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   290 SGHK-YSCPHCPYTASKKFLITRHSRSHDVEPSFKCSICERSFRSNVGLQNHINTHMGNKPHKCK 353
            :|.| |.|..|....|.:..:.||.|:|..|...||:.|.::|..:..|:.|..||.|.||:.|.
  Rat   126 TGEKLYKCIQCGKAFSDQNTLQRHKRTHSEEKPCKCNQCGKAFAHHSSLRKHERTHTGEKPYGCN 190

  Fly   354 LCESAFTTSGELVRHTR-------YK--------------------HTKEKPHKCTECTYASVEL 391
            .|:.||.....|.||.|       |:                    ||.|||:.|.:|..|....
  Rat   191 QCDKAFACHSSLRRHERTHTGEKPYECNQCDKAFAYHSSLQKHERTHTGEKPYGCNQCDKAFACH 255

  Fly   392 TKLRRHMTCHTGERPYQCPHCTYASQDMFKLKRHMVIHTGEKKYQCDICKSRFTQSNSLKAHKLI 456
            :.||:|...||||:||:|..|..|......|::|..||||||.|:|:.|...|:..|:|:.|:..
  Rat   256 SSLRKHERTHTGEKPYECNQCGKAFACHSTLRKHERIHTGEKPYECNQCGKAFSMQNTLRVHERT 320

  Fly   457 HSVVDKPVFQCNYCPTTCGRKADLRVHIKHMHTSDVPMTCRRCGQQLPDRYQYKLHVKSHEGEKC 521
            |: .:|| |:||.|..|....:.||:| |.:||.:.|..|.:||:.......::.|.:.|.|||.
  Rat   321 HT-GEKP-FECNQCGKTFKLHSQLRIH-KRVHTGEKPHECDQCGKTFACPSSFQKHKRVHSGEKP 382

  Fly   522 YSCKLCSYASVTQRHLASHMLIHLDEKPFHCDQCPQAFRQRQLLRRHMNLVHNEEYQPPEPRE-- 584
            |.|..|..|......|..|...|..||||.|:||.:.|.|...|:     ||...:...:|.|
  Rat   383 YGCNQCDKAFAIHSRLRKHERTHTGEKPFKCNQCGKTFSQSNSLQ-----VHKRTHTGEKPYECN 442

  Fly   585 ----------------------KLHKCPSCPREFTHKGNLMRHMETH 609
                                  |.::|..|.:.|.:..:|.||..||
  Rat   443 QCGKAFPYDSSLRVHERTHTGMKPYECNQCGKAFGYHSHLQRHERTH 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CTCF	NP_648109.1	23ISL	<116..206	CDD:293226
		C2H2 Zn finger	296..316	CDD:275368	6/19 (32%)
		COG5048	321..>621	CDD:227381	108/340 (32%)
		zf-C2H2	322..344	CDD:278523	6/21 (29%)
		C2H2 Zn finger	324..344	CDD:275368	5/19 (26%)
		zf-H2C2_2	337..361	CDD:290200	11/23 (48%)
		C2H2 Zn finger	352..373	CDD:275368	9/47 (19%)
		C2H2 Zn finger	381..401	CDD:275368	6/19 (32%)
		zf-H2C2_2	394..415	CDD:290200	11/20 (55%)
		C2H2 Zn finger	409..429	CDD:275368	5/19 (26%)
		zf-H2C2_2	422..446	CDD:290200	12/23 (52%)
		C2H2 Zn finger	437..457	CDD:275368	6/19 (32%)
		C2H2 Zn finger	467..485	CDD:275368	7/17 (41%)
		C2H2 Zn finger	496..516	CDD:275370	4/19 (21%)
		C2H2 Zn finger	524..544	CDD:275368	5/19 (26%)
		zf-H2C2_2	536..561	CDD:290200	11/24 (46%)
		C2H2 Zn finger	552..573	CDD:275368	6/20 (30%)
		zf-C2H2	587..609	CDD:278523	6/21 (29%)
		C2H2 Zn finger	589..609	CDD:275368	6/19 (32%)
Zfp958	XP_038944925.1	KRAB	4..44	CDD:396083
		C2H2 Zn finger	80..97	CDD:275368
		C2H2 Zn finger	105..125	CDD:275368
		COG5048	129..490	CDD:227381	118/369 (32%)
		C2H2 Zn finger	133..153	CDD:275368	6/19 (32%)
		C2H2 Zn finger	161..181	CDD:275368	5/19 (26%)
		C2H2 Zn finger	189..209	CDD:275368	8/19 (42%)
		C2H2 Zn finger	217..237	CDD:275368	0/19 (0%)
		C2H2 Zn finger	245..265	CDD:275368	6/19 (32%)
		C2H2 Zn finger	273..293	CDD:275368	5/19 (26%)
		C2H2 Zn finger	301..321	CDD:275368	6/19 (32%)
		C2H2 Zn finger	329..349	CDD:275368	8/20 (40%)
		C2H2 Zn finger	357..377	CDD:275368	4/19 (21%)
		C2H2 Zn finger	385..405	CDD:275368	5/19 (26%)
		C2H2 Zn finger	413..433	CDD:275368	8/24 (33%)
		C2H2 Zn finger	441..461	CDD:275368	0/19 (0%)
		C2H2 Zn finger	469..489	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000