DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CTCF and zfp64

DIOPT Version :9

Sequence 1:	NP_648109.1	Gene:	CTCF / 38817	FlyBaseID:	FBgn0035769	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	XP_017944788.1	Gene:	zfp64 / 100125785	XenbaseID:	XB-GENE-976615	Length:	661	Species:	Xenopus tropicalis

Alignment Length:	597	Identity:	145/597 - (24%)
Similarity:	236/597 - (39%)	Gaps:	149/597 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   260 NADKKDVDFVLSN-----KEVKLKTASSTSQNSNASGHKYSCPHCPYTASKKFLITRHSRSHDVE 319
            |.....|.||..|     .:...:|.:|.:|....|...:...|    ..:.||.:.::.|...|
Frog    59 NGATSAVQFVPQNDTGTPTQTSPRTITSETQTIAVSAPGFVFEH----GYQTFLPSENAESQTTE 119

  Fly   320 ---PSFKC------SICER---------SFRSNVG---LQNHINTHMGNKPHKCKLCESAFTTSG 363
               |..||      |...|         .|::..|   |:.|:.||.|:|||||..|:.||:...
Frog   120 RTIPPIKCRRTVSGSSSRRKHSCTYPGCQFKTAYGLKDLERHLRTHTGDKPHKCPTCDKAFSRKD 184

  Fly   364 ELVRHTRYKHTKEKPHKCTECTYASVELTKLRRHMTCHTGERPYQCPHCTYASQDMFKLKRHMVI 428
            :|..|.| .||.|||.||.||.|.:.:.:.|.:|...||.|||::|..|.|||::..:|..|:..
Frog   185 KLKTHMR-SHTGEKPFKCKECDYRAADSSSLCKHQRIHTNERPFKCQICPYASRNSSQLTVHLRS 248

  Fly   429 HTGEKKYQCDICKSRFTQSNSLKAHKLIHSVVDKPVFQCNYCPTTCGRKADLRVHIKHMHTSDVP 493
            |||:..:||.:|.::|..::.||.|..:|: .:|| |:|::|...|..|.:|:.||:..|.::..
Frog   249 HTGDAPFQCILCNAKFKINSDLKRHMRVHT-GEKP-FRCDFCNFVCAMKGNLKSHIRMKHNTETT 311

  Fly   494 MTCRRCGQQLPDRYQYKLHVKSHEGEKCYSCKLCSYASVTQRHLASHMLIHLDEKPFHCDQCPQA 558
            ..|..|..|...:...:.||:.|..|:...|..|||:..::..|..|..||..::||.|..|...
Frog   312 FKCLECNFQCGSKADLRQHVRCHLPEQPVKCADCSYSCSSKAALKVHERIHSKDRPFKCSFCQFD 376

  Fly   559 FRQRQLLRRHMNLVHNEEYQP----------PEPR------------EKLHKCPSCPREFTHKGN 601
            .:||..|..|:...|.::.:|          ..||            :|.:.|..|...|..:.:
Frog   377 TKQRSNLTTHIKKCHGDQVKPRKSSLHRKEGDSPRHYTSRKGTKLEAKKAYNCDLCDASFVREDS 441

  Fly   602 LMRHMETHDDSANAREKR-------------------RRLK-------LGRN-VRLQKDGTVI-- 637
            |..|.:.|.:...|::..                   |.:|       .|:: |:|..|..:|
Frog   442 LRSHKKQHSEIIAAQKASGLDFIPLATSAPRSSTIAIRNIKFPTTILPFGQDGVKLMGDHPLIEG 506

  Fly   638 ----------------TLIKDQYV----------------------------------DMDRDQE 652
                            ..::|...                                  .:|....
Frog   507 ATAETTSEPARALDSMAKVQDHMATSQLRLLSQVNLIASPSAAQKLALPDIGNNPIQHHLDESGT 571

  Fly   653 ENEEDDNPESYDLAEIEPENSEAED----ADDDVE-TIVSDP---IRQR-------IKPAPIIIN 702
            :|:::.|.|::..|....|.|:.:.    .::.|| |||||.   ||..       ..|:|::..
Frog   572 DNDQETNDEAFMSASSIDECSDLDHLHIIKEEPVEVTIVSDAGDYIRMEEPHQSPVFSPSPLVNT 636

  Fly   703 KQARLAASEKQP 714
            .:......::.|
Frog   637 PKRSYIVVQEDP 648

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CTCF	NP_648109.1	23ISL	<116..206	CDD:293226
		C2H2 Zn finger	296..316	CDD:275368	3/19 (16%)
		COG5048	321..>621	CDD:227381	103/358 (29%)
		zf-C2H2	322..344	CDD:278523	8/39 (21%)
		C2H2 Zn finger	324..344	CDD:275368	7/37 (19%)
		zf-H2C2_2	337..361	CDD:290200	13/23 (57%)
		C2H2 Zn finger	352..373	CDD:275368	7/20 (35%)
		C2H2 Zn finger	381..401	CDD:275368	6/19 (32%)
		zf-H2C2_2	394..415	CDD:290200	9/20 (45%)
		C2H2 Zn finger	409..429	CDD:275368	7/19 (37%)
		zf-H2C2_2	422..446	CDD:290200	9/23 (39%)
		C2H2 Zn finger	437..457	CDD:275368	6/19 (32%)
		C2H2 Zn finger	467..485	CDD:275368	6/17 (35%)
		C2H2 Zn finger	496..516	CDD:275370	5/19 (26%)
		C2H2 Zn finger	524..544	CDD:275368	6/19 (32%)
		zf-H2C2_2	536..561	CDD:290200	8/24 (33%)
		C2H2 Zn finger	552..573	CDD:275368	6/20 (30%)
		zf-C2H2	587..609	CDD:278523	5/21 (24%)
		C2H2 Zn finger	589..609	CDD:275368	5/19 (26%)
zfp64	XP_017944788.1	COG5048	<147..451	CDD:227381	98/306 (32%)
		zf-H2C2_2	157..182	CDD:372612	13/24 (54%)
		C2H2 Zn finger	173..193	CDD:275368	7/20 (35%)
		zf-H2C2_2	186..209	CDD:372612	13/23 (57%)
		C2H2 Zn finger	201..221	CDD:275368	6/19 (32%)
		C2H2 Zn finger	229..249	CDD:275368	7/19 (37%)
		C2H2 Zn finger	257..277	CDD:275368	6/19 (32%)
		C2H2 Zn finger	285..303	CDD:275368	6/17 (35%)
		C2H2 Zn finger	314..334	CDD:275368	5/19 (26%)
		C2H2 Zn finger	342..362	CDD:275368	6/19 (32%)
		C2H2 Zn finger	370..388	CDD:275368	6/17 (35%)
		C2H2 Zn finger	429..449	CDD:275368	5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910