Protein Alignment CTCF and ctcf

DIOPT Version :10

• Sequence 1: NP_648109.1
• Gene: CTCF / 38817
• FlyBaseID: FBgn0035769
• Length: 818
• Species: Drosophila melanogaster
• Sequence 2: NP_001116268.1
• Gene: ctcf / 100101689
• XenbaseID: XB-GENE-862914
• Length: 734
• Species: Xenopus tropicalis
• Alignment Length: 780
• Identity: 238/780 - (30%)
• Similarity: 340/780 - (43%)
• Gaps: 149/780 - (19%)

  Fly    71 AEEAEEEEEDDEDKYFID---------------DEGNCYIKTTPKKQKE---------------- 104
            :|.||...||.|.  |:.               ||.||.|..:.....|
 Frog     3 SEMAEAVVEDSET--FMKRKETKTYQRRREGGVDEDNCVIVQSQTDISEVPHDVNSNVQMVMMEQ 65

  Fly   105 -----LQKK---LKQAAAKPGKATRSVVSTATNKSINL--RPAK-----------STPKATTSKP 148
                 ||.|   ::...::.|..|.......|.:.:|:  :|..           :.|.|||
 Frog    66 LDPTLLQMKTEVMEGVVSQEGDPTVDDTQIITLQVVNMEEQPINLGELQLVQVPVAVPMATT--- 127

  Fly   149 PPEPKAISVRPARAAAAK--AKQSAMPPPPALVVKVPAPRG----RPRKNPVIPKPEPMDLEREL 207
                   ||....||...  :|:......|.:...:|.|.|    :...|..:...|..:|:::.
 Frog   128 -------SVGELHAAFENEVSKEGLQEGEPMICHTLPLPEGFQVVKVGANGEVETLEQAELQQQE 185

  Fly   208 EE-LVDEPDISSMVTELSD-------YTVDEAAVEAATATLTPNEAEVYEFED---NATTEDENA 261
            |. ...:||....:.:...       ||.:...|:.:          ||:||:   .....|.||
 Frog   186 EPGWQKDPDYVPPIKKTKKTKKSKLRYTEEGKDVDVS----------VYDFEEEQQEGLLSDVNA 240

  Fly   262 DKKDVDFVLSNKEVKLKTASSTSQNSNASGHKYSCPHCPYTASKKFLITRHSRSHDVEPSFKCSI 326
            :|     |:.|    :|....|..........:.|..|.||..::..:.||.:||..|...||.:
 Frog   241 EK-----VVGN----MKPPKPTKIKKKGVKKTFQCELCSYTCPRRSNLDRHMKSHTDERPHKCHL 296

  Fly   327 CERSFRSNVGLQNHINTHMGNKPHKCKLCESAFTTSGELVRHTRYKHTKEKPHKCTECTYASVEL 391
            |.|:||:...|:||:|||.|.:||||..|:.||.||||||||.|||||.|||.||:.|.|||||:
 Frog   297 CGRAFRTVTLLRNHLNTHTGTRPHKCPDCDMAFVTSGELVRHRRYKHTHEKPFKCSMCDYASVEV 361

  Fly   392 TKLRRHMTCHTGERPYQCPHCTYASQDMFKLKRHMVIHTGEKKYQCDICKSRFTQSNSLKAHKLI 456
            :||:||:..||||||:||..|:|||:|.:||||||..|:|||.|:|.||.:|||||.::|.|.|.
 Frog   362 SKLKRHIRSHTGERPFQCSLCSYASRDTYKLKRHMRTHSGEKPYECYICHARFTQSGTMKMHILQ 426

  Fly   457 HSVVDKPVFQCNYCPTTCGRKADLRVHIKHMHT-SDVPMTCRRCGQQLPDRYQYKLHVKSHEGEK 520
            ....:...|.|.:|.|...||:||.||::..|: .:....||.|.....:||....|.|||:.||
 Frog   427 KHTENVAKFHCPHCDTVIARKSDLGVHLRKQHSYIEQGKKCRYCDTVFHERYALIQHQKSHKNEK 491

  Fly   521 CYSCKLCSYASVTQRHLASHMLIHLDEKPFHCDQCPQAFRQRQLLRRHMNLVHNEEYQPPEPREK 585
            .:.|..|.||...:||:..|...|..|||:.|..|.:.|||:|||..|....|:..:.|     .
 Frog   492 RFKCDQCEYACRQERHMIMHKRTHTGEKPYACSHCDKTFRQKQLLDMHFKRYHDPSFVP-----A 551

  Fly   586 LHKCPSCPREFTHKGNLMRHMET-----HDDSANAREKRRRLKLGRNVRLQKDGTVITLIKDQYV 645
            ...|..|.:.||.:..:.||.:.     ..|..|..|.....|.|:..|.:|
 Frog   552 AFVCSKCGKTFTRRNTMSRHADNCTGPDGTDGENGGESEVVHKKGKRGRKRK------------- 603

  Fly   646 DMDRDQEENEEDDNPESYDLAEIEPENSEAEDADDDVET---IVSDP-IRQRIKPAPIIINKQ-- 704
              .|.::|...|    |.|.||.|.|:.:.||.||:.||   |.:|| ..:.:.|.|....|:
 Frog   604 --MRSKKEGSSD----SEDNAEPELEDDDDEDEDDEDETPVEIEADPEPEEPLTPLPPPAKKRRG 662

  Fly   705 ---ARLAASEKQPMIINQRLRSQRGTKTF--HIKEEPDNSDFTVEWQGDDGEVM---VVELVNGD 761
               .:...:::...:|.....|.|..:..  .:|:|.|     :|.:|.....:   .||..|||
 Frog   663 RPPGKANQAKQNAAVIQVDDHSNRAIENIIVQVKKESD-----LEAEGGVEAAVPTPAVEAPNGD 722

  Fly   762  761
             Frog   723  722

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CTCF	NP_648109.1	FAP	116..>202	CDD:429334	20/104 (19%)
		C2H2 Zn finger	296..316	CDD:275368	6/19 (32%)
		COG5048	321..>621	CDD:227381	136/305 (45%)
		C2H2 Zn finger	324..344	CDD:275368	9/19 (47%)
		C2H2 Zn finger	352..373	CDD:275368	14/20 (70%)
		C2H2 Zn finger	381..401	CDD:275368	11/19 (58%)
		zf-H2C2_2	394..415	CDD:463886	12/20 (60%)
		C2H2 Zn finger	409..429	CDD:275368	12/19 (63%)
		zf-H2C2_2	422..446	CDD:463886	15/23 (65%)
		C2H2 Zn finger	437..457	CDD:275368	11/19 (58%)
		C2H2 Zn finger	467..485	CDD:275368	9/17 (53%)
		C2H2 Zn finger	496..516	CDD:275370	7/19 (37%)
		C2H2 Zn finger	524..544	CDD:275368	7/19 (37%)
		zf-H2C2_2	536..561	CDD:463886	9/24 (38%)
		C2H2 Zn finger	552..573	CDD:275368	9/20 (45%)
		zf-C2H2	587..609	CDD:395048	6/26 (23%)
		C2H2 Zn finger	589..609	CDD:275368	6/24 (25%)
ctcf	NP_001116268.1	zf-H2C2_5	264..287	CDD:404746	7/22 (32%)
		C2H2 Zn finger	266..286	CDD:275368	6/19 (32%)
		zf-H2C2_2	278..303	CDD:463886	10/24 (42%)
		C2H2 Zn finger	294..314	CDD:275368	9/19 (47%)
		zf-H2C2_2	307..331	CDD:463886	14/23 (61%)
		C2H2 Zn finger	322..345	CDD:275368	16/22 (73%)
		zf-H2C2_5	349..373	CDD:404746	13/23 (57%)
		C2H2 Zn finger	351..371	CDD:275368	11/19 (58%)
		COG5048	<364..498	CDD:227381	61/133 (46%)
		C2H2 Zn finger	379..399	CDD:275368	12/19 (63%)
		C2H2 Zn finger	407..424	CDD:275368	9/16 (56%)
		C2H2 Zn finger	437..455	CDD:275368	9/17 (53%)
		C2H2 Zn finger	467..487	CDD:275368	7/19 (37%)
		C2H2 Zn finger	495..515	CDD:275368	7/19 (37%)
		zf-H2C2_2	507..532	CDD:463886	9/24 (38%)
		C2H2 Zn finger	523..544	CDD:275368	9/20 (45%)
		C2H2 Zn finger	555..571	CDD:275368	4/15 (27%)