DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CTCF and zfp64

DIOPT Version :9

Sequence 1:	NP_648109.1	Gene:	CTCF / 38817	FlyBaseID:	FBgn0035769	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	NP_001373446.1	Gene:	zfp64 / 100003733	ZFINID:	ZDB-GENE-031118-80	Length:	642	Species:	Danio rerio

Alignment Length:	527	Identity:	127/527 - (24%)
Similarity:	222/527 - (42%)	Gaps:	84/527 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   265 DVDFVLSNKEVKLKTASSTSQNSNASGHKYSCPHCPYTASKKFLITRHSRSHDVEPSF--KCSIC 327
            :|:...::|:...:..|:.....|| |...|...|.....|.....:.:.|..::|:.  |..||
Zfish    32 NVELFFAHKQNCCQIPSTHISVRNA-GASESLQTCVSKVKKTLTKAQKNPSKKLKPALTQKRHIC 95

  Fly   328 ERS---FRSNVG---LQNHINTHMGNKPHKCKLCESAFTTSGELVRHTRYKHTKEKPHKCTECTY 386
            ..|   |::..|   ::.||.||.|.:|.:|:||...|:...:|..|:|. ||.||||||..|||
Zfish    96 TFSGCTFKTQYGQKDMERHILTHTGERPFECELCHKRFSRRDKLNLHSRL-HTGEKPHKCKYCTY 159

  Fly   387 ASVELTKLRRHMTCHTGERPYQCPHCTYASQDMFKLKRHMVIHTGEKKYQCDICKSRFTQSNSLK 451
            |:.:.:.|::|:..|..|||::|..|.|||::..:|..|:..|||:..:||:.|.::|..::.||
Zfish   160 AAADSSSLKKHLRIHYDERPFKCQICPYASRNSSQLTVHLRSHTGDAPFQCNQCDAKFKINSDLK 224

  Fly   452 AHKLIHSVVDKPVFQCNYCPTTCGRKADLRVHIKHMHTSDVPMTCRRCGQQLPDRYQYKLHVKSH 516
            .|..:|| .:|| ::|:.|...|..||:|:.|:...|::.....|.:|..|...:...:.|.:.|
Zfish   225 RHSRVHS-GEKP-YKCDLCDYRCAMKANLKSHVHLKHSASDSFHCSKCDFQCSTKAALRHHSRQH 287

  Fly   517 EGEKCYSCKLCSYASVTQRHLASHMLIHLDEKPFHCDQCPQAFRQRQLLRRHMNLVH-------- 573
            :..:...|..|||:..::..|..|..:|.||:||.||.|..|.:||..|..|....|
Zfish   288 QPAQPLQCSECSYSCSSKGALKIHERVHSDERPFKCDLCSFASKQRSNLLIHTRKCHADKPDRLS 352

  Fly   574 ----------------NEEYQPPEPREKLHKCPSCPREFTHKGNLMRHMETHDDSANAREKRRRL 622
                            :..|:......:.::|..|...|..:.:|..|...|::....:...:..
Zfish   353 KSGRISGNGEDLTKPISSRYRAKLEATRAYRCDLCEASFVREDSLRSHKRQHNNITQQQSHNQTS 417

  Fly   623 KLGRNVRLQK--DGTVITLIKDQYVDMDRDQEENEEDDNPESYDLAE---------------IEP 670
            :......:|.  :.::.|                   ::|.:|:...               ::.
Zfish   418 QTSTKQPVQNIPEASIAT-------------------ESPSTYNTTHLKIIVAPSLGSEASFVQT 463

  Fly   671 ENSEAEDADDDVETIVSDPIRQRIKP-AP-----------IIINKQARLAASEKQPMIINQRLRS 723
            ..|.|.....|...::.:|:.|.:.. ||           ..|:....::.|..|..|.:....:
Zfish   464 SKSGAVLLGSDDHDVLLNPVLQHVSMLAPEGALEHQTVLLAQISPSETVSQSSSQNFIASCSASA 528

  Fly   724 QRGTKTF 730
            ...|.||
Zfish   529 SEATHTF 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CTCF	NP_648109.1	23ISL	<116..206	CDD:293226
		C2H2 Zn finger	296..316	CDD:275368	2/19 (11%)
		COG5048	321..>621	CDD:227381	98/331 (30%)
		zf-C2H2	322..344	CDD:278523	8/29 (28%)
		C2H2 Zn finger	324..344	CDD:275368	7/25 (28%)
		zf-H2C2_2	337..361	CDD:290200	10/23 (43%)
		C2H2 Zn finger	352..373	CDD:275368	7/20 (35%)
		C2H2 Zn finger	381..401	CDD:275368	7/19 (37%)
		zf-H2C2_2	394..415	CDD:290200	8/20 (40%)
		C2H2 Zn finger	409..429	CDD:275368	7/19 (37%)
		zf-H2C2_2	422..446	CDD:290200	9/23 (39%)
		C2H2 Zn finger	437..457	CDD:275368	6/19 (32%)
		C2H2 Zn finger	467..485	CDD:275368	7/17 (41%)
		C2H2 Zn finger	496..516	CDD:275370	4/19 (21%)
		C2H2 Zn finger	524..544	CDD:275368	6/19 (32%)
		zf-H2C2_2	536..561	CDD:290200	11/24 (46%)
		C2H2 Zn finger	552..573	CDD:275368	8/20 (40%)
		zf-C2H2	587..609	CDD:278523	5/21 (24%)
		C2H2 Zn finger	589..609	CDD:275368	5/19 (26%)
zfp64	NP_001373446.1	C2H2 Zn finger	95..118	CDD:275368	6/22 (27%)
		zf-H2C2_2	110..135	CDD:404364	10/24 (42%)
		C2H2 Zn finger	126..146	CDD:275368	7/20 (35%)
		zf-H2C2_2	139..162	CDD:404364	15/23 (65%)
		C2H2 Zn finger	154..174	CDD:275368	7/19 (37%)
		SFP1	<176..260	CDD:227516	31/85 (36%)
		C2H2 Zn finger	182..202	CDD:275368	7/19 (37%)
		C2H2 Zn finger	210..230	CDD:275368	6/19 (32%)
		zf-H2C2_2	222..246	CDD:404364	9/25 (36%)
		C2H2 Zn finger	238..257	CDD:275368	7/18 (39%)
		C2H2 Zn finger	323..341	CDD:275368	8/17 (47%)
		C2H2 Zn finger	384..404	CDD:275368	5/19 (26%)
		SP1-4_N	<408..>605	CDD:425404	18/147 (12%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	77	1.000	Domainoid score	I8831
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000