DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eco and Esco1

DIOPT Version :9

Sequence 1:	NP_648106.1	Gene:	eco / 38812	FlyBaseID:	FBgn0035766	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_001074691.1	Gene:	Esco1 / 77805	MGIID:	1925055	Length:	843	Species:	Mus musculus

Alignment Length:	1017	Identity:	218/1017 - (21%)
Similarity:	381/1017 - (37%)	Gaps:	258/1017 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 MRLNSNSSSNSRNSSPRQTRVQRKRADSSMSSPTSSSEGTPSSRARNSIRRSPRTFSAQKDPDAF 175
            |.:...|..||       :.|.::..|.::.....||:.:|:.::.:.        .|.|.|..|
Mouse     1 MSIQEKSKENS-------SIVTKESEDENLEEEVESSQNSPTKKSGSK--------EAVKTPVRF 50

  Fly   176 SSPESFQTRLSKVAAMLMKGQDSRSMLEKSKKKHNHSLKTTAQVHTTKPKKTSPAEESQSDDEKP 240
            |                            :|.|.|.|         ....:.|....|.|.|:..
Mouse    51 S----------------------------NKSKTNES---------EFGMRMSTRSASCSADKTA 78

  Fly   241 SSSKNSRKNTEVRETRSSQIISPKTRNRRRPFTSADINCKTLKAAAHLHENMRSYDEEKTAAVKL 305
            ::|.|  |||...:.:|.:  |.||:...:...|..|    ||....||.  ||...::......
Mouse    79 TNSFN--KNTVTLKGQSQE--SSKTKKLCQEKLSLGI----LKGNEQLHR--RSQRLQQLTECTT 133

  Fly   306 ENSRSRS-KSPVEVFKSNDDAVKRNTGNTNNKTAKSSEVAT----AKRPESPGSSMKIDVEVPES 365
            .:.|||. ...::..|.|..:.:|.  ..|:..:|.::|..    .||     ..::|..:..|.
Mouse   134 RSLRSREIHGQIQTVKQNQQSARRE--QCNSTQSKCNKVKVNQKHVKR-----KVLEIKSDCKED 191

  Fly   366 DEEASNH-------KPQKRQHPETSTPVAPSADADSGSP---QSKMRKVTLSSSIPTMAFYSHSG 420
            ....:|.       |.:|.||..|||   .|:..:.||.   |...||..: ..:|..|
Mouse   192 RHSVTNEVINSPKGKKRKVQHQTTST---CSSQCNQGSEKCLQKTSRKEEI-KPVPVTA------ 246

  Fly   421 EAVTKSRRRPSI--SKNSLKQP--TKIS-PTSRPLLGINKGVHHKIRKRHGFANRLPATDMDNIL 480
             .:.|.:...|:  .||.|::.  |::| .|.||.:.:.....|...:....|.:.....:..:.
Mouse   247 -DIRKLKAATSVVSKKNELRKSAHTQVSTSTKRPQIPLPLVPEHSDDQELEQAGKSKRGSILQLC 310

  Fly   481 NSLSNERLKNLITTKREERAKVEEVHQILRNAKDPIKMAKPLSV-IEADDANNNNNLPATAWQET 544
            ..::.|...:.:..|:|.            :..:.:|..||..| ::..||...
Mouse   311 EEIAGEIESDTVEVKKES------------SCVESVKEEKPAEVKLQGTDAERQ----------- 352

  Fly   545 SADFSDLSDVEDIDPIIEVEPIIPIIRHEPVQKSPTAEPADLSKRKFFKSGR-RSSTCMEVRITD 608
                                    |:.|:...:       |:...:||.|.: :...|    :.:
Mouse   353 ------------------------ILHHKEANQ-------DVRSNRFFPSRKTKPVKC----VLN 382

  Fly   609 NIRASVSQGKIELVQTIRRKPRQVRVKSATIFSAEQATVDAILK---NLDDT-VVDEIVE-ANPV 668
            .|.:|.           ::.....::|.:...|.:|..:|:.:.   ||..| :...::| .:||
Mouse   383 GINSST-----------KKNSNWTKIKLSKFNSVQQHKLDSQVSPKLNLLQTGLSTSVLEMPHPV 436

  Fly   669 VQATPIDAE---ETTMETESLPDIIEYAPEANDVEIDPFAEFRQRLP---------YQTDDPNVV 721
            .|:|.::.:   ..|.:.:.:..|.....:.|::.|: ..:..:|.|         ..:.|.::.
Mouse   437 SQSTFLEMKAHGNVTCQRDKMKGIKSEEVKINNIAIE-INKATKRDPGNCNLDNHIKPSPDSSLD 500

  Fly   722 EQQQILLEFLISNN--ICTEKNFEIFIANPDDYKDEANQIVDNLYMVVNSEEAAQLAQMETV--E 782
            .|.::..|.....|  ||:....|   .||                :.|:..|:.|.....:  :
Mouse   501 NQMKLSCESAPDQNFSICSASEVE---TNP----------------LENTAAASTLLSQAKIDED 546

  Fly   783 NTAVAIAPKQ------DAPAVEEVQPKLFPIFTQ-----RLQPVVQKSLRRRPDTSMRLLTAAGG 836
            .|....||.|      |..::......:.|..:|     .|:..:.|||:.:....:       .
Mouse   547 RTFPGSAPNQQHSVLSDEASINRKNRDVPPNHSQLKHDSHLEITIPKSLKLKDSEKV-------D 604

  Fly   837 SNQYQIDAGQKAFGARQCQQCGLVYTVHEPEEELLHREYHNS-IHVLRFKGWIDEDIVSVYPEWA 900
            ..|..||||.|.|||..|..||::||...||:|..|..:||. |..:::.||..|.|::.||
Mouse   605 EKQLVIDAGHKRFGAVSCNICGMLYTASNPEDETQHLLFHNQFISAVKYVGWKKERILAEYP--- 666

  Fly   901 SDGRIIRINERAPTARLDRLRDLIGVVDKELGYSS-----YIVPKIFVAFIAVRKQQIVGFCLVQ 960
             |||||.:....|...|.::.::..:||.:||:..     |...|..: ||: ..:::||..:.:
Mouse   667 -DGRIIMVLPEDPKYALKKVDEIREMVDNDLGFQQAPLMCYSRTKTLL-FIS-NDKKVVGCLIAE 728

  Fly   961 PLSQAHRFIQVDGTDYFSEES----------------YPASCGVSRIWVSPLQRRSGIASKLLRV 1009
            .:...:|.|:.......|||.                .||.||:|||||..:.||..|||:::..
Mouse   729 HIQWGYRVIEEKLPVIRSEEEKVRFERQKAWCCSTLPEPAICGISRIWVFSMMRRKKIASRMIEC 793

  Fly  1010 VQCHTVLGQEIARECIAFSTPTDDGRALARQFTGLDNFLTYD 1051
            ::.:.:.|..:::|.||||.||.||:..|.|:.|...||.|:
Mouse   794 LRSNFIYGSYLSKEEIAFSDPTPDGKLFATQYCGTGQFLVYN 835

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eco	NP_648106.1	zf-C2H2_3	839..878	CDD:290589	19/38 (50%)
		NAT_SF	945..>1008	CDD:173926	23/78 (29%)
		Acetyltransf_13	982..1043	CDD:290591	26/60 (43%)
Esco1	NP_001074691.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..78		22/128 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	262..300		9/37 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	546..584		7/37 (19%)
		zf-C2H2_3	607..646	CDD:290589	19/38 (50%)
		Acetyltransf_13	766..828	CDD:290591	26/61 (43%)
		Acetyl-CoA binding. /evidence=ECO:0000250\|UniProtKB:Q5FWF5	775..777		1/1 (100%)
		Acetyl-CoA binding. /evidence=ECO:0000250\|UniProtKB:Q5FWF5	783..788		2/4 (50%)
		Acetyl-CoA binding. /evidence=ECO:0000250\|UniProtKB:Q5FWF5	815..817		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	67	1.000	Domainoid score	I9802
eggNOG	1	0.900	-	-		E1_KOG3014
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002145
OrthoInspector	1	1.000	-	-		otm43203
orthoMCL	1	0.900	-	-		OOG6_102667
Panther	1	1.100	-	-	O	PTHR45884
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4551
SonicParanoid	1	1.000	-	-		X2551
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.890