DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eco and POLK

DIOPT Version :9

Sequence 1:	NP_648106.1	Gene:	eco / 38812	FlyBaseID:	FBgn0035766	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_001374040.1	Gene:	POLK / 51426	HGNCID:	9183	Length:	884	Species:	Homo sapiens

Alignment Length:	887	Identity:	172/887 - (19%)
Similarity:	291/887 - (32%)	Gaps:	267/887 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 INDDEDDADVDSLGVLPLKTHVAANRKGRSLFAAVPGKSSSSANSSPETNKENKKTRGGVMTATA 100
            :||::  |.::.|....:...:....|| |.|.....|.....|...|...:.|      ...|:
Human    21 LNDNK--AGMEGLDKEKINKIIMEATKG-SRFYGNELKKEKQVNQRIENMMQQK------AQITS 76

  Fly   101 EQL--PQLFTATMRLNSNSSSNSRNS----------SPRQTRVQRKRADSSMSSPTSSSEGTPSS 153
            :||  .||......:....|.|..|:          :..:.|...:..|..::..:.|...|.:.
Human    77 QQLRKAQLQVDRFAMELEQSRNLSNTIVHIDMDAFYAAVEMRDNPELKDKPIAVGSMSMLSTSNY 141

  Fly   154 RARN-SIRRSPRTFSAQK-DPDAFSSPESFQ--TRLSKVAAMLMKGQDSRSM------------- 201
            .||. .:|.:...|.|:: .|.....|.:|.  ..:||....::...|...|
Human   142 HARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKEVKEILADYDPNFMAMSLDEAYLNITK 206

  Fly   202 -LEKSKK----KHNHSLKTTAQVH--------------TTKPKK-----------TSPA--EESQ 234
             ||:.:.    |..:.:|..:.|.              |..|.|           .||.  |||.
Human   207 HLEERQNWPEDKRRYFIKMGSSVENDLQNLYIQRSITFTDNPGKEVNKLSEHERSISPLLFEESP 271

  Fly   235 SDDEKPSS----SKNSRKNTEVRET-----RSSQIISPKTRNRRRPFTSADINCKTLKAAAHLHE 290
            ||.:.|..    :...:.|.::.:.     .|:|.:..:.|.|....|       ||.|:|.:..
Human   272 SDVQPPGDPFQVNFEEQNNPQILQNSVVFGTSAQEVVKEIRFRIEQKT-------TLTASAGIAP 329

  Fly   291 NMRSYDEEKTAAVKLENSRSRSKSPVEVFKSND---DAVK-------RNTGNTNNKTAKSSEVAT 345
            |        |...|:.:.:::.....::..:..   |.:|       ...|....|..|:..:.|
Human   330 N--------TMLAKVCSDKNKPNGQYQILPNRQAVMDFIKDLPIRKVSGIGKVTEKMLKALGIIT 386

  Fly   346 AKR---------------------------------PESPGSSMKID---VEVPESDEEASNHKP 374
            ...                                 .:....||.::   .|:.:::|:.|..:
Human   387 CTELYQQRALLSLLFSETSWHYFLHISLGLGSTHLTRDGERKSMSVERTFSEINKAEEQYSLCQ- 450

  Fly   375 QKRQHPETSTPVAPSADADSGSPQSKMRKVTL-----SSSIPTMAFYSHSGEAVTKSRRRPSISK 434
                  |..:.:|    .|....:.|.|.||:     :..:.|.|  |.....|:.:....:|:|
Human   451 ------ELCSELA----QDLQKERLKGRTVTIKLKNVNFEVKTRA--STVSSVVSTAEEIFAIAK 503

  Fly   435 NSLKQPTKIS-----PTSRPLLGI-------NKGVHHKIRKRHGFAN-----------RLPATDM 476
            ..||  |:|.     |....|:|:       .:...|:.|...||..           .|..||.
Human   504 ELLK--TEIDADFPHPLRLRLMGVRISSFPNEEDRKHQQRSIIGFLQAGNQALSATECTLEKTDK 566

  Fly   477 DNILNSLSNERLKNLITTKREERA-------KVEEVHQILRNAKDPIKMAKPLSVIEADDANNNN 534
            |..:..|.....|:....||.||.       |.|.|:      |...:.::|..|::   ...|.
Human   567 DKFVKPLEMSHKKSFFDKKRSERKWSHQDTFKCEAVN------KQSFQTSQPFQVLK---KKMNE 622

  Fly   535 NLPATAWQETSADFSDLSDVEDIDPIIEVEPII----PIIRHEPVQK--SPTAEPADLSKR-KFF 592
            ||          :.|:.||    |..|...|:.    ..|..|.:.|  ....:...:|:. |.|
Human   623 NL----------EISENSD----DCQILTCPVCFRAQGCISLEALNKHVDECLDGPSISENFKMF 673

  Fly   593 KSGRRSSTCMEVRITDNIRASVSQGKIELVQTIRRKPRQVRVKSATIFSAEQATVDAILKNLDDT 657
            .....|:|  :|...:|:.||....|    |.....|   ::|       |.::||.|      .
Human   674 SCSHVSAT--KVNKKENVPASSLCEK----QDYEAHP---KIK-------EISSVDCI------A 716

  Fly   658 VVDEIVEANPVVQATPIDA---EETTMETESLPD---IIEYAPEAN----DVEIDPFAEFRQ--R 710
            :||.|..::   :|..|||   :.:..|..|||.   .||:..:.:    .:|.:....|||  |
Human   717 LVDTIDNSS---KAESIDALSNKHSKEECSSLPSKSFNIEHCHQNSSSTVSLENEDVGSFRQEYR 778

  Fly   711 LPYQTDDP----------NVVEQQQILLEFLISNNICTEKNF 742
            .||..:..          ||.::...|..|.:..::|..|:|
Human   779 QPYLCEVKTGQALVCPVCNVEQKTSDLTLFNVHVDVCLNKSF 820

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eco	NP_648106.1	zf-C2H2_3	839..878	CDD:290589
		NAT_SF	945..>1008	CDD:173926
		Acetyltransf_13	982..1043	CDD:290591
POLK	NP_001374040.1	PolY_Pol_IV_kappa	104..530	CDD:176459	76/455 (17%)
		ZnF_Rad18	635..661	CDD:128973	5/25 (20%)
		zf-WRNIP1_ubi	790..816	CDD:383112	4/25 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	830..872
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141251
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4551
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.960