DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eco and DNApol-eta

DIOPT Version :9

Sequence 1:	NP_648106.1	Gene:	eco / 38812	FlyBaseID:	FBgn0035766	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_649371.2	Gene:	DNApol-eta / 40438	FlyBaseID:	FBgn0037141	Length:	885	Species:	Drosophila melanogaster

Alignment Length:	494	Identity:	96/494 - (19%)
Similarity:	151/494 - (30%)	Gaps:	165/494 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 RQLFGSPRSRLRQINDDE----------------------------------DDADVDSLGVLPL 53
            :::|.:..::.|:::.||                                  :||..|.:...||
  Fly   459 QEMFANQAAKKRRVSGDEPGQLPKVEMEKKQKQTDEFKMKSFFANYLQGAKKEDAKADGISANPL 523

  Fly    54 KTHVAANRKG------RSLFAAVPGKSSSSANSSPETNKENKKTRGGVMTATAEQLPQLFTATMR 112
            .....|..|.      ..|.|||                   :|.|.|:|:|..:..:.|.:
  Fly   524 AAAAGAPNKNFVEEYKHKLHAAV-------------------RTEGTVLTSTPAEFKESFFS--- 566

  Fly   113 LNSNSSSNSRNSSPRQTRVQRKRADSSMSSPTSSSEGTPSSRARNSIRRSPRTFSAQKDPDAFSS 177
                           |...|:|:. ....|.||..:..........:.......|...:.|....
  Fly   567 ---------------QYLKQQKKT-GQQGSVTSREDSLDVQELAEELDAIEADNSKDFEEDTEEE 615

  Fly   178 PE-SFQTRLSKVAAMLMKGQDSRSMLEKSKKKHNHSLKTTAQVHT--TKPKKTSPAEESQSDDEK 239
            .| :..|.:||     .:||.|.:..|:.....|.|......|.|  ..|..|       .|:.|
  Fly   616 TELTSDTHMSK-----PEGQSSDAGQEQDPNTLNDSTGNDLYVETGIVPPTLT-------EDELK 668

  Fly   240 PSSSKNSRKNTEVRETRSS------QIISPKTRNRRRPFTSADINC--------KTLKA------ 284
            ||:||  ||..|:..:.|:      :...|..|....|....| .|        |:|:.
  Fly   669 PSTSK--RKFDEIESSVSNYKECYVEFAVPNLRTDILPTIKCD-QCGANIPDEVKSLQTHRDHHF 730

  Fly   285 AAHLHENMRSYDEEKTAAVKLENSRSRSK---SPVEVFKSNDDAVKRNTGNTNNKTAKSSEVAT- 345
            |..|...:||.:.|       |.::||.|   .|....||...|   .:|:::..||..|...|
  Fly   731 AQELSRTLRSTERE-------ERTQSRQKISLKPTPPKKSKKTA---GSGSSSYSTAPPSNSITK 785

  Fly   346 --------AKRPESPGSSM----KIDVEVPESDEEASNHKPQKRQ---------------HPETS 383
                    .:.|..|..:.    |..::..:..|....|..:..|               :.|..
  Fly   786 FFRAKPTQEQAPSDPQMNQCPECKAFIKCVDMPEHLDYHVARNLQRELNQQDLRTRTAALNKEKI 850

  Fly   384 TPVAPSADADSGSPQSKMRKVTLSSSIPTMA---FYSHS 419
            :||.|...:     |.|:.....:||..|..   |:|.|
  Fly   851 SPVQPKKQS-----QKKLNSTISASSSGTKTIAQFFSQS 884

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eco	NP_648106.1	zf-C2H2_3	839..878	CDD:290589
		NAT_SF	945..>1008	CDD:173926
		Acetyltransf_13	982..1043	CDD:290591
DNApol-eta	NP_649371.2	PolY_Pol_eta	20..447	CDD:176456
		zf_UBZ	705..736	CDD:408236	6/31 (19%)
		zf_UBZ	805..832	CDD:408236	4/26 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45452757
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4551
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.960