DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eco and Polk

DIOPT Version :9

Sequence 1:	NP_648106.1	Gene:	eco / 38812	FlyBaseID:	FBgn0035766	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_612525.1	Gene:	Polk / 171525	RGDID:	620058	Length:	851	Species:	Rattus norvegicus

Alignment Length:	666	Identity:	130/666 - (19%)
Similarity:	206/666 - (30%)	Gaps:	237/666 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 GRPSRMATPR-----LSERKRQ----LF----------GSPRSRLRQINDDEDDADVDSLGVLPL 53
            |...::.|||     |:||:|.    ||          |||    .|:|.:|.:
  Rat   225 GNCRKIDTPRQEADELTERERSISPLLFEDSPPDLQPQGSP----FQLNSEEQN----------- 274

  Fly    54 KTHVAANRKGRSLFAAVPGKSSSSANSSPETNKENKKTRGGVMTATAEQLPQLFTATMRLNSNSS 118
            ...:|.|       ..|.|.|:...........|.|.|    :||:|...|....|.:..:.|..
  Rat   275 NPQIAQN-------PVVFGTSAEEVVKEIRFRIEQKTT----LTASAGIAPNTMLAKVCSDKNKP 328

  Fly   119 SNSRNSSPRQ----------------------------------TRVQRKRADSSMSSPTSS--- 146
            :......|.:                                  |.:.::||..|:....||
  Rat   329 NGQYQIVPSRSAVMDFIKDLPIRKVSGIGKVTEKMLLALGIVTCTELYQQRALLSLLFSESSWHY 393

  Fly   147 ----SEGTPSS-RARNSIRRS---PRTFS-AQKDPDAFSSPESFQTRLSKVAAMLMKGQDSRSML 202
                :.|..|: .||:..|:|   .|||| ..|..:.:|..:...|.|:.  .:..:|...|::.
  Rat   394 FLHVALGLGSTDLARDGERKSMSVERTFSEINKTEEQYSLCQELCTELAH--DLQKEGLKGRTVT 456

  Fly   203 EKSKKKHNHSLKTTAQVHTTKPKKTSPAEE---------------------------------SQ 234
            .|.|.. :..:||.|   :|.|...|.||:                                 |.
  Rat   457 IKLKNV-DFEVKTRA---STVPSAISTAEDIFAVAKELLRTEVTAGSPQPLRLRLMGVRMSTFSN 517

  Fly   235 SDDEK------------------PSSSKNSRKN-TEV---RETRSSQIISPKTRNRRRPFTSADI 277
            .||.|                  |:.....|.: ||:   .||...:....|.|:.|.|......
  Rat   518 DDDRKHQQRSIIGFLQAGNQGLSPTGCTADRTDKTELVKPLETSRKKSFFDKKRSERIPNCQDPP 582

  Fly   278 NCK-----TLKAAAHLHENMRSYDEEKTAAVKLENS------------RSRSKSPVEVFKSNDDA 325
            .||     .|:|:.......:..:..||:    |||            |.:....:|.|..:.||
  Rat   583 RCKIAGEQALQASEPSQALKKMSESFKTS----ENSNDPQTFICPVCFREQEGISLEAFNEHVDA 643

  Fly   326 VKRNTGNTNNKTAKSSEVATAKRPESPGSSMKIDVEVP------ESDEEASNHKPQKRQHPETST 384
            ..     ....|:::||:.:.....|.....:....||      ..|.|.::.........|..:
  Rat   644 CL-----DGPSTSENSEMPSYSHASSADIGQQAHRAVPLWEKRGHGDGEITSGDGADLTETEDRS 703

  Fly   385 PVAPSADA-------DSGSPQSKMRKVTLSSSIPTMAFYSHSGEAVTKSRRRPSISKNSLKQP-T 441
            |.|.|.||       ..|.|.|:.:...||.:..|::                ::|:....|| |
  Rat   704 PKAASMDAVGNNHSEGEGYPDSQGKSCPLSPANETVS----------------TLSREDSAQPCT 752

  Fly   442 KISPTSRPL----------------------LGINKGVHHKIRKRHGFANRLPATDMDNILNSLS 484
            ....|.|.|                      :.:|||:..::|.....:.:.|..      ::.|
  Rat   753 DEVVTGRALVCPVCNLEQETSDLTLFNIHVDICLNKGIIQELRNSEVNSVKQPKG------STRS 811

  Fly   485 NERLKNLI-TTKREER 499
            .:||:... .|||..|
  Rat   812 TDRLQKASGKTKRAGR 827

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eco	NP_648106.1	zf-C2H2_3	839..878	CDD:290589
		NAT_SF	945..>1008	CDD:173926
		Acetyltransf_13	982..1043	CDD:290591
Polk	NP_612525.1	PolY_Pol_IV_kappa	103..513	CDD:176459	63/319 (20%)
		PRK02406	107..525	CDD:235035	67/331 (20%)
		ZnF_Rad18	620..645	CDD:128973	5/24 (21%)
		ZnF_Rad18	760..786	CDD:128973	1/25 (4%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334917
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930