DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eco and ESCO2

DIOPT Version :9

Sequence 1:	NP_648106.1	Gene:	eco / 38812	FlyBaseID:	FBgn0035766	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_001017420.1	Gene:	ESCO2 / 157570	HGNCID:	27230	Length:	601	Species:	Homo sapiens

Alignment Length:	738	Identity:	160/738 - (21%)
Similarity:	286/738 - (38%)	Gaps:	230/738 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   365 SDEEASNHKPQKRQHPETS----TPVAPSADADSGSPQSKMRKVTLSSSIPTMAFYSHSGEAVTK 425
            ||:...|....:::|...|    |.:.....|:.|||        ..|::.|::||:.:...:..
Human    40 SDKNEENLHCSQQEHFVLSALKTTEINRLPSANQGSP--------FKSALSTVSFYNQNKWYLNP 96

  Fly   426 SRRRPSISKNSLKQPTKISPTSRPLLGINKGVHHKIRKRHGFANRLPATDMDNILNSLSNERLKN 490
            ..|:......|....|.....|.|:      |..|::.:       |.....|      |::.:.
Human    97 LERKLIKESRSTCLKTNDEDKSFPI------VTEKMQGK-------PVCSKKN------NKKPQK 142

  Fly   491 LITTKREERAK-VEEVHQILRNAKDPIKMAKPLSVIEADD----ANNNNNLPATAWQETSADFSD 550
            .:|.|.:.:.: ::.|.:..||:|....:.||  ::|.::    |.||:|.|....|:
Human   143 SLTAKYQPKYRHIKPVSRNSRNSKQNRVIYKP--IVEKENNCHSAENNSNAPRVLSQK------- 198

  Fly   551 LSDVEDIDPIIEVEPIIPIIRHEPVQKSPTAEPADLSKRKFFKSGRRSSTCMEVRITDNIRASVS 615
                  |.|.:.::                      ....||           ||...::|.|..
Human   199 ------IKPQVTLQ----------------------GGAAFF-----------VRKKSSLRKSSL 224

  Fly   616 QGKIELVQTIRRKPRQVRVKSATIFSAEQATVDAILKNLDDTVVDEIVEANPVVQATPIDAEETT 680
            :.:..|.:|.:.|                               .|::|.:.|...    :|:.|
Human   225 ENEPSLGRTQKSK-------------------------------SEVIEDSDVETV----SEKKT 254

  Fly   681 METESLPDIIEYAPEANDVEIDPFAEFRQRLPYQTDDPNVVEQQQILLEFLISNNICTEKNFEIF 745
            ..|..:|..:                              |.::::.:..|.:::    ||.|..
Human   255 FATRQVPKCL------------------------------VLEEKLKIGLLSASS----KNKEKL 285

  Fly   746 IANPDDYKDEANQIVDNLYMVVNSEEAAQLAQMETVENTAVAIAPKQDAPAVEEVQPKLFPIFTQ 810
            |      ||.::..|.:....|:..||.. ::....||.  .|:||.          .::|||:.
Human   286 I------KDSSDDRVSSKEHKVDKNEAFS-SEDSLGENK--TISPKS----------TVYPIFSA 331

  Fly   811 ---------------------RLQPVVQKSLRRRPDTSMRLLTAAGGSNQYQIDAGQKAFGARQC 854
                                 ..|..:||:...| |||.:.      .:|..||||||.|||..|
Human   332 SSVNSKRSLGEEQFSVGSVNFMKQTNIQKNTNTR-DTSKKT------KDQLIIDAGQKHFGATVC 389

  Fly   855 QQCGLVYTVHEPEEELLH-REYHNSIHVLRFKGWIDEDIVSVYPEWASDGRIIRINERAPTARLD 918
            :.||::||...||:|:.| :.:|..:..:::.||..|.:|:.:  |  ||:|:.:....|:..:.
Human   390 KSCGMIYTASNPEDEMQHVQHHHRFLEGIKYVGWKKERVVAEF--W--DGKIVLVLPHDPSFAIK 450

  Fly   919 RLRDLIGVVDKELGYSSYIVPK--------IFVAFIAVRKQQIVGFCLVQPLSQAHRFI------ 969
            ::.|:..:||.|||:.. :|||        :|::    .::::||..:.:|:.||.|.:
Human   451 KVEDVQELVDNELGFQQ-VVPKCPNKIKTFLFIS----DEKRVVGCLIAEPIKQAFRVLSEPIGP 510

  Fly   970 -QVDGTD-----YFSEESYPASCGVSRIWVSPLQRRSGIASKLLRVVQCHTVLGQEIARECIAFS 1028
             ....|:     ..|:...||.||:|||||..|:||..||.:|:..::...:.|..::.:.||||
Human   511 ESPSSTECPRAWQCSDVPEPAVCGISRIWVFRLKRRKRIARRLVDTLRNCFMFGCFLSTDEIAFS 575

  Fly  1029 TPTDDGRALARQFTGLDNFLTYD 1051
            .||.||:..|.::....|||.|:
Human   576 DPTPDGKLFATKYCNTPNFLVYN 598

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eco	NP_648106.1	zf-C2H2_3	839..878	CDD:290589	20/39 (51%)
		NAT_SF	945..>1008	CDD:173926	23/74 (31%)
		Acetyltransf_13	982..1043	CDD:290591	25/60 (42%)
ESCO2	NP_001017420.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	222..243		5/51 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	282..315		8/39 (21%)
		zf-C2H2_3	374..413	CDD:290589	19/38 (50%)
		Acetyltransf_13	529..591	CDD:290591	25/61 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	67	1.000	Domainoid score	I9809
eggNOG	1	0.900	-	-		E1_KOG3014
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5634
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002145
OrthoInspector	1	1.000	-	-		otm41134
orthoMCL	1	0.900	-	-		OOG6_102667
Panther	1	1.100	-	-	LDO	PTHR45884
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4551
SonicParanoid	1	1.000	-	-		X2551
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.750