DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eco and ESCO1

DIOPT Version :9

Sequence 1:	NP_648106.1	Gene:	eco / 38812	FlyBaseID:	FBgn0035766	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_443143.2	Gene:	ESCO1 / 114799	HGNCID:	24645	Length:	840	Species:	Homo sapiens

Alignment Length:	943	Identity:	211/943 - (22%)
Similarity:	375/943 - (39%)	Gaps:	204/943 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   200 SMLEKSKKKHNHSLKTTAQVHTTKPKKTSPAEESQSDDEKPSSSKNSRKNTEVRETRSSQIISPK 264
            |:.||||:..:              |.|..:::..|:.|...|.||..|.:..:||..||..|..
Human     3 SIQEKSKENSS--------------KVTKKSDDKNSETEIQDSQKNLAKKSGPKETIKSQAKSSS 53

  Fly   265 TRNRRRPFTSADINCKTLKAAAH------LHEN---MRSYDEEKTAAVKLENSRSRSKSPVEVFK 320
            .....:|.....::.::.|||::      :::|   :|.|.:|.|.. ||...:...::|    |
Human    54 ESKINQPELETRMSTRSSKAASNDKATKSINKNTVTVRGYSQESTKK-KLSQKKLVHENP----K 113

  Fly   321 SNDDAVKRNTGNTNNKTAKSSEVA--TAKRPESPGSSMKIDVEVP-------ESDEEASNHKPQK 376
            :|:...:|     :.:..:.:||:  :.:..|..|....:...:|       .|.:..||...||
Human   114 ANEQLNRR-----SQRLQQLTEVSRRSLRSREIQGQVQAVKQSLPPTKKEQCSSTQSKSNKTSQK 173

  Fly   377 RQHPETSTPVAPSADADS-------GSPQSKMRKVTLSSSIPTMAFYSHSGE-AVTKSRRR---- 429
            ....:.....:.|.:.::       .||:.|.|||...::....:..:...| ...|:.||
Human   174 HVKRKVLEVKSDSKEDENLVINEVINSPKGKKRKVEHQTACACSSQCTQGSEKCPQKTTRRDETK 238

  Fly   430 --PSIS--KNSLKQPTKISPTSRPLLGINKGVHHKIRKRHGFANRLPATDMDNILNSLSNERLKN 490
              |..|  |.| |..|.:.|....:   .|.||.::...    ..||.:...::.....|| |:.
Human   239 PVPVTSEVKRS-KMATSVVPKKNEM---KKSVHTQVNTN----TTLPKSPQPSVPEQSDNE-LEQ 294

  Fly   491 LITTKREERAKV-EEVHQILRNAKDPIKMAKPLSVIEADDANNNNNLPATAWQETSADFSDLSDV 554
            ...:||....:: ||:                ...||:|:.            |...:.|.:..|
Human   295 AGKSKRGSILQLCEEI----------------AGEIESDNV------------EVKKESSQMESV 331

  Fly   555 EDIDPIIEVEPIIPIIRHEPVQKSPTAEPADLSKRKFFKSGR-RSSTCMEVRITDNIRASVSQGK 618
            ::..| .|::.....:..:.:.:..|.:  |:...:||.|.: :...|    |.:.|.:|.
Human   332 KEEKP-TEIKLEETSVERQILHQKETNQ--DVQCNRFFPSRKTKPVKC----ILNGINSSA---- 385

  Fly   619 IELVQTIRRKPRQVRVKSATIFSAEQATVDA-------ILKNLDDTVVDEIVEANPVVQA----T 672
                   ::.....::|.:...|.:...:|:       :|:........|:  .:||.|:    |
Human   386 -------KKNSNWTKIKLSKFNSVQHNKLDSQVSPKLGLLRTSFSPPALEM--HHPVTQSTFLGT 441

  Fly   673 PIDAEETTMETESLPDIIEYAPEANDVEIDPFAEFRQRLP--------YQTDDPNVVEQQQILLE 729
            .:.....|.:.|.:.:|.....:.||:.:: ..:..:|.|        .:..||.:..|.:...:
Human   442 KLHDRNITCQQEKMKEINSEEVKINDITVE-INKTTERAPENCHLANEIKPSDPPLDNQMKHSFD 505

  Fly   730 FLISNNI--CTEKNFEIFIANPDDYKDEANQIVDNLYMVVNSEEAAQLAQMETVENTAVAIAPKQ 792
            ...:.|.  |.|...|             |..|:|   |..:......|:::|.||.....||:|
Human   506 SASNKNFSQCLESKLE-------------NSPVEN---VTAASTLLSQAKIDTGENKFPGSAPQQ 554

  Fly   793 DAPAVEEVQ--------PK--LFPIFTQRLQPVVQKSLRRRPDTSMRLLTAAGGSNQYQ--IDAG 845
            .:....:..        |:  ..|.....|:..:.|.|:         |..|..:::.|  ||||
Human   555 HSILSNQTSKSSDNRETPRNHSLPKCNSHLEITIPKDLK---------LKEAEKTDEKQLIIDAG 610

  Fly   846 QKAFGARQCQQCGLVYTVHEPEEELLHREYHNS-IHVLRFKGWIDEDIVSVYPEWASDGRIIRIN 909
            ||.|||..|..||::||...||:|..|..:||. |..:::.||..|.|::.||    |||||.:.
Human   611 QKRFGAVSCNVCGMLYTASNPEDETQHLLFHNQFISAVKYVGWKKERILAEYP----DGRIIMVL 671

  Fly   910 ERAPTARLDRLRDLIGVVDKELGYSS-----YIVPKIFVAFIAVRKQQIVGFCLVQPLSQAHRFI 969
            ...|...|.::.::..:||.:||:..     |...|..: ||: ..:::||..:.:.:...:|.|
Human   672 PEDPKYALKKVDEIREMVDNDLGFQQAPLMCYSRTKTLL-FIS-NDKKVVGCLIAEHIQWGYRVI 734

  Fly   970 QVDGTDYFSEES----------------YPASCGVSRIWVSPLQRRSGIASKLLRVVQCHTVLGQ 1018
            :.......|||.                .||.||:|||||..:.||..|||:::..::.:.:.|.
Human   735 EEKLPVIRSEEEKVRFERQKAWCCSTLPEPAICGISRIWVFSMMRRKKIASRMIECLRSNFIYGS 799

  Fly  1019 EIARECIAFSTPTDDGRALARQFTGLDNFLTYD 1051
            .:::|.||||.||.||:..|.|:.|...||.|:
Human   800 YLSKEEIAFSDPTPDGKLFATQYCGTGQFLVYN 832

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eco	NP_648106.1	zf-C2H2_3	839..878	CDD:290589	20/40 (50%)
		NAT_SF	945..>1008	CDD:173926	23/78 (29%)
		Acetyltransf_13	982..1043	CDD:290591	26/60 (43%)
ESCO1	NP_443143.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..188		44/208 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	221..300		19/87 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	318..338		4/32 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	486..505		3/18 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	542..582		8/39 (21%)
		zf-C2H2_3	604..643	CDD:290589	20/38 (53%)
		Acetyltransf_13	763..825	CDD:290591	26/61 (43%)
		Acetyl-CoA binding. /evidence=ECO:0000269\|PubMed:27112597, ECO:0000269\|PubMed:27803161, ECO:0007744\|PDB:4MXE, ECO:0007744\|PDB:5T53	772..774		1/1 (100%)
		Acetyl-CoA binding. /evidence=ECO:0000269\|PubMed:27112597, ECO:0000269\|PubMed:27803161, ECO:0007744\|PDB:4MXE, ECO:0007744\|PDB:5T53	780..785		2/4 (50%)
		Acetyl-CoA binding. /evidence=ECO:0000269\|PubMed:27112597, ECO:0000269\|PubMed:27803161, ECO:0007744\|PDB:4MXE, ECO:0007744\|PDB:5T53	812..814		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	67	1.000	Domainoid score	I9809
eggNOG	1	0.900	-	-		E1_KOG3014
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	136	1.000	Inparanoid score	I4566
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002145
OrthoInspector	1	1.000	-	-		otm41134
orthoMCL	1	0.900	-	-		OOG6_102667
Panther	1	1.100	-	-	O	PTHR45884
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4551
SonicParanoid	1	1.000	-	-		X2551
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.940