Protein Alignment eco and ESCO1

DIOPT Version :10

• Sequence 1: NP_648106.1
• Gene: eco / 38812
• FlyBaseID: FBgn0035766
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: NP_443143.2
• Gene: ESCO1 / 114799
• HGNCID: 24645
• Length: 840
• Species: Homo sapiens
• Alignment Length: 943
• Identity: 211/943 - (22%)
• Similarity: 375/943 - (39%)
• Gaps: 204/943 - (21%)

  Fly   200 SMLEKSKKKHNHSLKTTAQVHTTKPKKTSPAEESQSDDEKPSSSKNSRKNTEVRETRSSQIISPK 264
            |:.||||:..:              |.|..:::..|:.|...|.||..|.:..:||..||..|..
Human     3 SIQEKSKENSS--------------KVTKKSDDKNSETEIQDSQKNLAKKSGPKETIKSQAKSSS 53

  Fly   265 TRNRRRPFTSADINCKTLKAAAH------LHEN---MRSYDEEKTAAVKLENSRSRSKSPVEVFK 320
            .....:|.....::.::.|||::      :::|   :|.|.:|.|.. ||...:...::|    |
Human    54 ESKINQPELETRMSTRSSKAASNDKATKSINKNTVTVRGYSQESTKK-KLSQKKLVHENP----K 113

  Fly   321 SNDDAVKRNTGNTNNKTAKSSEVA--TAKRPESPGSSMKIDVEVP-------ESDEEASNHKPQK 376
            :|:...:|     :.:..:.:||:  :.:..|..|....:...:|       .|.:..||...||
Human   114 ANEQLNRR-----SQRLQQLTEVSRRSLRSREIQGQVQAVKQSLPPTKKEQCSSTQSKSNKTSQK 173

  Fly   377 RQHPETSTPVAPSADADS-------GSPQSKMRKVTLSSSIPTMAFYSHSGE-AVTKSRRR---- 429
            ....:.....:.|.:.::       .||:.|.|||...::....:..:...| ...|:.||
Human   174 HVKRKVLEVKSDSKEDENLVINEVINSPKGKKRKVEHQTACACSSQCTQGSEKCPQKTTRRDETK 238

  Fly   430 --PSIS--KNSLKQPTKISPTSRPLLGINKGVHHKIRKRHGFANRLPATDMDNILNSLSNERLKN 490
              |..|  |.| |..|.:.|....:   .|.||.::...    ..||.:...::.....|| |:.
Human   239 PVPVTSEVKRS-KMATSVVPKKNEM---KKSVHTQVNTN----TTLPKSPQPSVPEQSDNE-LEQ 294

  Fly   491 LITTKREERAKV-EEVHQILRNAKDPIKMAKPLSVIEADDANNNNNLPATAWQETSADFSDLSDV 554
            ...:||....:: ||:                ...||:|:.            |...:.|.:..|
Human   295 AGKSKRGSILQLCEEI----------------AGEIESDNV------------EVKKESSQMESV 331

  Fly   555 EDIDPIIEVEPIIPIIRHEPVQKSPTAEPADLSKRKFFKSGR-RSSTCMEVRITDNIRASVSQGK 618
            ::..| .|::.....:..:.:.:..|.:  |:...:||.|.: :...|    |.:.|.:|.
Human   332 KEEKP-TEIKLEETSVERQILHQKETNQ--DVQCNRFFPSRKTKPVKC----ILNGINSSA---- 385

  Fly   619 IELVQTIRRKPRQVRVKSATIFSAEQATVDA-------ILKNLDDTVVDEIVEANPVVQA----T 672
                   ::.....::|.:...|.:...:|:       :|:........|:  .:||.|:    |
Human   386 -------KKNSNWTKIKLSKFNSVQHNKLDSQVSPKLGLLRTSFSPPALEM--HHPVTQSTFLGT 441

  Fly   673 PIDAEETTMETESLPDIIEYAPEANDVEIDPFAEFRQRLP--------YQTDDPNVVEQQQILLE 729
            .:.....|.:.|.:.:|.....:.||:.:: ..:..:|.|        .:..||.:..|.:...:
Human   442 KLHDRNITCQQEKMKEINSEEVKINDITVE-INKTTERAPENCHLANEIKPSDPPLDNQMKHSFD 505

  Fly   730 FLISNNI--CTEKNFEIFIANPDDYKDEANQIVDNLYMVVNSEEAAQLAQMETVENTAVAIAPKQ 792
            ...:.|.  |.|...|             |..|:|   |..:......|:::|.||.....||:|
Human   506 SASNKNFSQCLESKLE-------------NSPVEN---VTAASTLLSQAKIDTGENKFPGSAPQQ 554

  Fly   793 DAPAVEEVQ--------PK--LFPIFTQRLQPVVQKSLRRRPDTSMRLLTAAGGSNQYQ--IDAG 845
            .:....:..        |:  ..|.....|:..:.|.|:         |..|..:::.|  ||||
Human   555 HSILSNQTSKSSDNRETPRNHSLPKCNSHLEITIPKDLK---------LKEAEKTDEKQLIIDAG 610

  Fly   846 QKAFGARQCQQCGLVYTVHEPEEELLHREYHNS-IHVLRFKGWIDEDIVSVYPEWASDGRIIRIN 909
            ||.|||..|..||::||...||:|..|..:||. |..:::.||..|.|::.||    |||||.:.
Human   611 QKRFGAVSCNVCGMLYTASNPEDETQHLLFHNQFISAVKYVGWKKERILAEYP----DGRIIMVL 671

  Fly   910 ERAPTARLDRLRDLIGVVDKELGYSS-----YIVPKIFVAFIAVRKQQIVGFCLVQPLSQAHRFI 969
            ...|...|.::.::..:||.:||:..     |...|..: ||: ..:::||..:.:.:...:|.|
Human   672 PEDPKYALKKVDEIREMVDNDLGFQQAPLMCYSRTKTLL-FIS-NDKKVVGCLIAEHIQWGYRVI 734

  Fly   970 QVDGTDYFSEES----------------YPASCGVSRIWVSPLQRRSGIASKLLRVVQCHTVLGQ 1018
            :.......|||.                .||.||:|||||..:.||..|||:::..::.:.:.|.
Human   735 EEKLPVIRSEEEKVRFERQKAWCCSTLPEPAICGISRIWVFSMMRRKKIASRMIECLRSNFIYGS 799

  Fly  1019 EIARECIAFSTPTDDGRALARQFTGLDNFLTYD 1051
            .:::|.||||.||.||:..|.|:.|...||.|:
Human   800 YLSKEEIAFSDPTPDGKLFATQYCGTGQFLVYN 832

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eco	NP_648106.1	PRK08581	189..>477	CDD:236304	66/310 (21%)
		zf-C2H2_3	839..878	CDD:464013	20/40 (50%)
		NAT_SF	945..>1008	CDD:173926	23/78 (29%)
		Acetyltransf_13	982..1050	CDD:464015	29/67 (43%)
ESCO1	NP_443143.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..188		44/208 (21%)
		PTZ00121	<5..>350	CDD:173412	80/406 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	221..300		19/87 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	318..338		4/32 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	486..505		3/18 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	542..582		8/39 (21%)
		zf-C2H2_3	604..643	CDD:464013	20/38 (53%)
		Acetyltransf_13	763..831	CDD:464015	29/67 (43%)