DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eco and esco2

DIOPT Version :9

Sequence 1:	NP_648106.1	Gene:	eco / 38812	FlyBaseID:	FBgn0035766	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	XP_012819470.1	Gene:	esco2 / 100158558	XenbaseID:	XB-GENE-5955289	Length:	788	Species:	Xenopus tropicalis

Alignment Length:	1039	Identity:	228/1039 - (21%)
Similarity:	363/1039 - (34%)	Gaps:	380/1039 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 RKRADSSMSSP-TSSSEGTPSSR-----------------ARNSIRRSP--RTFSAQKDPDAFSS 177
            |||..||:||. ..:..|||..:                 :|.:||:||  .|::...||
Frog     7 RKRKRSSVSSDGRQAFYGTPVKKLIVEYDDCPSPLTTRNSSRRNIRKSPPVTTYTNMADP----- 66

  Fly   178 PESFQTRLSKVAAMLMKGQDSRSMLEKSKKKHNHSLKTTAQVHTTKPKKTSPAEESQSDDEKPSS 242
                 |....|.|..:|...:|.::                   ..|.:|:||
Frog    67 -----TEKENVGASPLKSNAARKLV-------------------VSPIQTAPA------------ 95

  Fly   243 SKNSRKNTEVRETRSSQIISPKTRNRRRPFTSADINCKTLKAAAHLHENMRS-YDEEKTAAVKLE 306
                                ||......|.|::.......|::.    :.|| |..:|.....|:
Frog    96 --------------------PKAAYGNSPLTASPRAASPFKSSV----STRSFYKRDKMYVTPLD 136

  Fly   307 NSR-SRSKSPVEVFKSNDDAVKRNTGNTNNKTAKSSEVAT----AKRPES--------------- 351
            ... :.|||.:            ::||.::.::.:|.|||    |||.:.
Frog   137 RKLINESKSSL------------SSGNESSVSSPTSPVATIAPRAKRNKKQPGKRKSGPKGKKTP 189

  Fly   352 PGSSMK-IDVEV------PESDEEAS-NHKPQKRQHPETSTPVAPSADADSGSPQSKMRKVTLSS 408
            |||..| |:|..      |.||:.|. |..|.|      ||| :|.:|..:|        |....
Frog   190 PGSGKKAINVPARKPTPSPRSDKGAGVNTLPSK------STP-SPCSDKGAG--------VNTLP 239

  Fly   409 SIPTMAFYSHSGEAV----TKSRRRPSISK----NSLKQPTKISPTSRPLLGINKGVHHKIRKRH 465
            |.||.:..|..|..|    :||...|...|    |:|  |:|.:|:.|.    :||..
Frog   240 SKPTPSPRSDKGAGVNTLPSKSTPSPCSDKGAGVNTL--PSKPTPSPRS----DKGAG------- 291

  Fly   466 GFANRLPATDMDNILNSLSNERLKNLITTKREERAKVEEVHQILRNAKDPIKMAKPLSVIEADDA 530
              .|.||:               |...:.:.::.|.|..:            .:||.....:|..
Frog   292 --VNTLPS---------------KPTPSPRSDKGAGVNTL------------PSKPTPSPRSDKG 327

  Fly   531 NNNNNLPATAWQETSADFSDLSDVEDIDPIIEVEPIIPIIRHEPVQKSPTAEPADLSKRKFFKSG 595
            ...|.||:....|          ||:...:..::.....::.:|..|....       ..||.:|
Frog   328 AGVNTLPSKPTPE----------VEESAGVPSMKTTFLGLKMKPRPKLTVG-------AAFFATG 375

  Fly   596 RRSSTCMEVRITDNIRASVSQGKIELVQTIRRKPRQVRVKSATIFSAEQATVDAILKNLDDTVVD 660
            :|..:..: |.:.||:          ...:.:.|:|..|
Frog   376 KRPHSAPK-RPSPNIK----------FPPLAKPPKQSTV-------------------------- 403

  Fly   661 EIVEANPVVQATPIDAEETTMETESLPDIIEYAPEANDVEIDPFAEFRQRLPYQTDDPNVVEQQQ 725
                  |:.:|.|        ...:|..::                            .|.|.|:
Frog   404 ------PITKALP--------PHSALKGVV----------------------------CVAEGQK 426

  Fly   726 ILLEFLISNNICTEKNFEIFIANPDDYKDEANQIVDNLYMVVNSEEAAQ------LAQMETVENT 784
            ...|...:.|:.:|.     :|.    |.|:|:.|.     :..:.|.|      .||..|....
Frog   427 QGQEGRKACNVPSES-----VAK----KPESNKEVK-----LTKDHAGQESLPTSPAQAGTGMQR 477

  Fly   785 AVAIAPKQDAPAVEEVQ------------PKLFPIFTQRLQPVVQK-SLRRRPDTSMRLLTAAG- 835
            |   ||  |:|.::|.:            |.:||||:   .|...| .|..|.|.:..:.::..
Frog   478 A---AP--DSPVIDEGEDSSVPKPSNKKGPTVFPIFS---TPAGNKRPLDLRGDLASPVFSSTPT 534

  Fly   836 ---------------------GSNQYQIDAGQKAFGARQCQQCGLVYTVHEPEEELLHREYHNS- 878
                                 ..:|..||||||.||...|..||:||.....|:|..|.:||..
Frog   535 NAPAALRFPKQGKKKREGRKVAEDQLVIDAGQKHFGPIACNTCGMVYAAANLEDEAQHVQYHQRL 599

  Fly   879 IHVLRFKGWIDEDIVSVYPEWASDGRIIRINERAPTARLDRLRDLIGVVDKELGYS--SYIVPK- 940
            :..:|:.||..|.:::.:  |  ||:||.::...|...|.:..::..:||.|||:.  |...|.
Frog   600 LEGIRYVGWKKERVITEF--W--DGKIIMVSPDDPKYALKKAEEVRELVDSELGFQQVSLRCPSQ 660

  Fly   941 ----IFVAFIAVRKQQIVGFCLVQPLSQAHRFIQVDGTDY--------------FSEESYPASCG 987
                :||:    .:::|||..:.:|:.:|:|.:....:.:              .|.|..||.||
Frog   661 TRTYMFVS----NEKKIVGCLIAEPIREAYRVLAEPPSPHSVHREPLERHRAWRCSTEPEPAICG 721

  Fly   988 VSRIWVSPLQRRSGIASKLLRVVQCHTVLGQEIARECIAFSTPTDDGRALARQFTGLDNFLTYD 1051
            :|||||..|.||..|||:|:..|:...:.|..:..|.||||.||.||:..|..:..:.:||.|:
Frog   722 ISRIWVFALMRRKAIASRLVDSVRSSFMYGSVLTTEEIAFSDPTPDGKLFASTYCKVPDFLVYN 785

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eco	NP_648106.1	zf-C2H2_3	839..878	CDD:290589	19/38 (50%)
		NAT_SF	945..>1008	CDD:173926	24/76 (32%)
		Acetyltransf_13	982..1043	CDD:290591	28/60 (47%)
esco2	XP_012819470.1	PHA03307	38..>349	CDD:223039	92/454 (20%)
		PHA03247	<200..537	CDD:223021	95/511 (19%)
		zf-C2H2_3	559..598	CDD:372777	19/38 (50%)
		Acetyltransf_13	716..784	CDD:372779	30/67 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	64	1.000	Domainoid score	I9967
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002145
OrthoInspector	1	1.000	-	-		otm48340
Panther	1	1.100	-	-	LDO	PTHR45884
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2551
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.100