DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lark and RBM4B

DIOPT Version :9

Sequence 1:	NP_523957.1	Gene:	lark / 38811	FlyBaseID:	FBgn0011640	Length:	352	Species:	Drosophila melanogaster
Sequence 2:	NP_113680.1	Gene:	RBM4B / 83759	HGNCID:	28842	Length:	359	Species:	Homo sapiens

Alignment Length:	347	Identity:	114/347 - (32%)
Similarity:	169/347 - (48%)	Gaps:	75/347 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 KLFIGNLDEKTQATELRALFEKYGTVVECDVVKNYGFVHMETEQQGRDAIQNLNGYTLNEFAIKV 72
            |||||||..:....|:|:|||:||.|:|||::|||||||:|.:....|||:||:.|.|:...|.|
Human     3 KLFIGNLPREATEQEIRSLFEQYGKVLECDIIKNYGFVHIEDKTAAEDAIRNLHHYKLHGVNINV 67

  Fly    73 EAAKSRRAPNTPTTKIFVGNLTDKTRAPEVRELFQKYGTVVECDIVRNYGFVHLDCVGDVQDAIK 137
            ||:|::   :..:||:.|||::......|:|..|::||.|:|||||::|.|||::...|..:||:
Human    68 EASKNK---SKASTKLHVGNISPTCTNQELRAKFEEYGPVIECDIVKDYAFVHMERAEDAVEAIR 129

  Fly   138 ELNGRVVDGQPLKVQVSTSRVRPKPGMGDPEQCYRCGRSGHWSKECP-----------RLYGSAG 191
            .|:.....|:.:.||:||||:|..|||||...|||||:.||||||||           ..|....
Human   130 GLDNTEFQGKRMHVQLSTSRLRTAPGMGDQSGCYRCGKEGHWSKECPVDRTGRVADFTEQYNEQY 194

  Fly   192 GGREPPSPLSAGGYRDRMYGRDPYPPPPPPPPFLRDRIMDGFRDYDYYDRRFEDSRDLYERRYQT 256
            |....|..:   ||.:.||..|.|..                  .|||            :||
Human   195 GAVRTPYTM---GYGESMYYNDAYGA------------------LDYY------------KRY-- 224

  Fly   257 SRMRDFPPPPISRREPMPLPPTLSGSLRSCSVSRGYDTMFSRRSPPPPRSSNGMSRYGSPTPHGY 321
             |:|.:.                  ::.:.:.:..|:......|..|...|..::.:.:.|
Human   225 -RVRSYE------------------AVAAAAAASAYNYAEQTMSHLPQVQSTTVTSHLNST---- 266

  Fly   322 EDFSRDAFDERMISSRGMRGPS 343
               |.|.:|..::.:.|....|
Human   267 ---SVDPYDRHLLPNSGAAATS 285

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lark	NP_523957.1	RRM1_2_CoAA_like	8..73	CDD:409779	34/64 (53%)
		RRM1_2_CoAA_like	87..152	CDD:409779	24/64 (38%)
		hnRNP-R-Q	<88..>258	CDD:273732	62/180 (34%)
RBM4B	NP_113680.1	RRM1_RBM4	2..68	CDD:410018	34/64 (53%)
		RRM2_RBM4	78..144	CDD:410019	25/65 (38%)
		PTZ00368	<145..>181	CDD:173561	23/35 (66%)
		ZnF_C2HC	161..176	CDD:197667	11/14 (79%)
		Interaction with TNPO3. /evidence=ECO:0000250	196..359		24/151 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	74	1.000	Domainoid score	I9137
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	191	1.000	Inparanoid score	I3876
Isobase	1	0.950	-	0	Normalized mean entropy	S3124
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1563362at2759
OrthoFinder	1	1.000	-	-		FOG0002310
OrthoInspector	1	1.000	-	-		otm40448
orthoMCL	1	0.900	-	-		OOG6_104638
Panther	1	1.100	-	-	LDO	PTHR23147
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4630
SonicParanoid	1	1.000	-	-		X1736
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.950