Protein Alignment lark and SAFB

DIOPT Version :10

• Sequence 1: NP_523957.1
• Gene: lark / 38811
• FlyBaseID: FBgn0011640
• Length: 352
• Species: Drosophila melanogaster
• Sequence 2: NP_001188267.1
• Gene: SAFB / 6294
• HGNCID: 10520
• Length: 917
• Species: Homo sapiens
• Alignment Length: 450
• Identity: 105/450 - (23%)
• Similarity: 149/450 - (33%)
• Gaps: 148/450 - (32%)

  Fly    10 FIGNLDEKTQATELRALFEKYGTVVECDVVKN--------YGFVHMETEQQGRDAIQNLNGYTLN 66
            ::..|...|:||:|:.||.|||.||...||.|        ||||.|.|.::....|.:|:...|:
Human   409 WVSGLSSTTRATDLKNLFSKYGKVVGAKVVTNARSPGARCYGFVTMSTAEEATKCINHLHKTELH 473

  Fly    67 EFAIKVEAAKSRRAPNTPTTKIFVGNLTDKTRAPEVRELFQKYGTVVECDIVRNYGFVHLDCVGD 131
            ...|.||.||     |.|     ||..|...|..:.::  :|     ..:..|:......|....
Human   474 GKMISVEKAK-----NEP-----VGKKTSDKRDSDGKK--EK-----SSNSDRSTNLKRDDKCDR 521

  Fly   132 VQDAIKELNGRVVDGQPLKVQVSTSRVRPKPGMGDPEQCYRCGRSG-------HWSKECPRLYGS 189
            ..||.|..:|   .|:..|.|..     .|||..:..:..:.|..|       ..||..|.:...
Human   522 KDDAKKGDDG---SGEKSKDQDD-----QKPGPSERSRATKSGSRGTERTVVMDKSKGVPVISVK 578

  Fly   190 AGGGREPPSP----LSAGGYRDRMYGRDPYPPPPPPP---------------------------- 222
            ..|.:|..|.    .||...:..:...|....|....
Human   579 TSGSKERASKSQDRKSASREKRSVVSFDKVKEPRKSRDSESHSRVRERSEREQRMQAQWEREERE 643

  Fly   223 ---------PFLRDRI---------MDGFRDYDYYDRRFEDSRDLYER---------RYQTSRMR 260
                     .|.|.|:         ::..|.:..::||.|..|...||         ||:..|.
Human   644 RLEIARERLAFQRQRLERERMERERLERERMHVEHERRREQERIHREREELRRQQELRYEQERR- 707

  Fly   261 DFP----PPPISRREPMPLPPTLSGSLRSCSVSRGYDTMFSR-----------RSPPPPRS---- 306
              |    |..:.||:....|     ..:..::...|.:.|:|           |...|..|
Human   708 --PAVRRPYDLDRRDDAYWP-----EAKRAALDERYHSDFNRQDRFHDFDHRDRGRYPDHSVDRR 765

  Fly   307 --SNGM----------SRYGSPTPHGYEDFSRDAF-----DERMISSRGMRGPSPP-GRR 348
              |..|          .|:|.|..||.:  |||.:     |:||...||:  |.|| |||
Human   766 EGSRSMMGEREGQHYPERHGGPERHGRD--SRDGWGGYGSDKRMSEGRGL--PPPPRGRR 821

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lark	NP_523957.1	RRM1_2_CoAA_like	8..73	CDD:409779	25/70 (36%)
		RRM1_2_CoAA_like	87..152	CDD:409779	13/64 (20%)
		hnRNP-R-Q	<88..>258	CDD:273732	41/235 (17%)
SAFB	NP_001188267.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..33
		SAP	31..65	CDD:128789
		PLN03124	32..>187	CDD:215591
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	64..118
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	221..407
		LGT	<227..399	CDD:469786
		RRM_SAFB1_SAFB2	405..480	CDD:410080	25/70 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	477..641		36/188 (19%)
		Interaction with POLR2A. Interaction with SFRS1, SFRS9 and SFRS10. /evidence=ECO:0000250|UniProtKB:O88453, ECO:0000269|PubMed:9671816	528..792		49/279 (18%)
		Nuclear localization signal. /evidence=ECO:0000255	599..616		2/16 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	671..708		10/39 (26%)
		RcnB	<733..>823	CDD:444206	26/92 (28%)