DRSC/TRiP Functional Genomics Resources

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Protein Alignment lark and RBM4

DIOPT Version :9

Sequence 1:NP_523957.1 Gene:lark / 38811 FlyBaseID:FBgn0011640 Length:352 Species:Drosophila melanogaster
Sequence 2:NP_002887.2 Gene:RBM4 / 5936 HGNCID:9901 Length:364 Species:Homo sapiens


Alignment Length:368 Identity:123/368 - (33%)
Similarity:173/368 - (47%) Gaps:82/368 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 KLFIGNLDEKTQATELRALFEKYGTVVECDVVKNYGFVHMETEQQGRDAIQNLNGYTLNEFAIKV 72
            |||||||..:....|:|:|||:||.|:|||::|||||||:|.:....|||:||:.|.|:...|.|
Human     3 KLFIGNLPREATEQEIRSLFEQYGKVLECDIIKNYGFVHIEDKTAAEDAIRNLHHYKLHGVNINV 67

  Fly    73 EAAKSRRAPNTPTTKIFVGNLTDKTRAPEVRELFQKYGTVVECDIVRNYGFVHLDCVGDVQDAIK 137
            ||:|::   :..:||:.|||::......|:|..|::||.|:|||||::|.|||::...|..:||:
Human    68 EASKNK---SKTSTKLHVGNISPTCTNKELRAKFEEYGPVIECDIVKDYAFVHMERAEDAVEAIR 129

  Fly   138 ELNGRVVDGQPLKVQVSTSRVRPKPGMGDPEQCYRCGRSGHWSKECP-----------RLYGSAG 191
            .|:.....|:.:.||:||||:|..|||||...|||||:.||||||||           ..|....
Human   130 GLDNTEFQGKRMHVQLSTSRLRTAPGMGDQSGCYRCGKEGHWSKECPIDRSGRVADLTEQYNEQY 194

  Fly   192 GGREPPSPLSAGG--YRDRMYGR-DPYPPPPPPPPFLRDRIMDGFRD--------YDYYDRRFED 245
            |....|..:|.|.  |.:..||. |.|        :.|.|....:..        |:|.::....
Human   195 GAVRTPYTMSYGDSLYYNNAYGALDAY--------YKRCRAARSYEAVAAAAASVYNYAEQTLSQ 251

  Fly   246 ----------------SRDLYERRY-----------------------QTSRM-RDFPPPPISRR 270
                            |.|.|:|..                       .||.. ||..|   .||
Human   252 LPQVQNTAMASHLTSTSLDPYDRHLLPTSGAAATAAAAAAAAAAVTAASTSYYGRDRSP---LRR 313

  Fly   271 EPMPLPPTLSGSLRSCSVSRGYDTMFSRRSPPPPRSSNGMSRY 313
            ...|:|....|      ...|:::..|:.|.....|...|:||
Human   314 ATAPVPTVGEG------YGYGHESELSQASAAARNSLYDMARY 350

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
larkNP_523957.1 RRM1_2_CoAA_like 8..73 CDD:409779 34/64 (53%)
RRM1_2_CoAA_like 87..152 CDD:409779 24/64 (38%)
hnRNP-R-Q <88..>258 CDD:273732 67/230 (29%)
RBM4NP_002887.2 RRM1_RBM4 2..68 CDD:410018 34/64 (53%)
RRM2_RBM4 78..144 CDD:410019 25/65 (38%)
PTZ00368 <145..>181 CDD:173561 23/35 (66%)
ZnF_C2HC 161..176 CDD:197667 11/14 (79%)
Interaction with TNPO3. /evidence=ECO:0000269|PubMed:12628928 196..364 33/172 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 74 1.000 Domainoid score I9137
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 191 1.000 Inparanoid score I3876
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1563362at2759
OrthoFinder 1 1.000 - - FOG0002310
OrthoInspector 1 1.000 - - otm40448
orthoMCL 1 0.900 - - OOG6_104638
Panther 1 1.100 - - LDO PTHR23147
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1736
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1110.930

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