DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment lark and Spen

DIOPT Version :9

Sequence 1:NP_523957.1 Gene:lark / 38811 FlyBaseID:FBgn0011640 Length:352 Species:Drosophila melanogaster
Sequence 2:XP_006539132.1 Gene:Spen / 56381 MGIID:1891706 Length:3644 Species:Mus musculus


Alignment Length:409 Identity:99/409 - (24%)
Similarity:144/409 - (35%) Gaps:95/409 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 TFKLFIGNLDEKTQATELRALFEKYGTVVECDV-----VKNYGFVHMETEQQGRDAIQNLNGYTL 65
            |..||||||::.|...:||.:|:::|.:|:.|:     |..|.|:..........||:.::|..|
Mouse   439 TRTLFIGNLEKTTTYHDLRNIFQRFGEIVDIDIKKVNGVPQYAFLQYCDIASVCKAIKKMDGEYL 503

  Fly    66 NEFAIKVEAAKSRRAPNTPTTKIFVGNLTDKTRAPEVRELFQKYGTVVEC--DIVRNYGFVHLDC 128
            ....:|:...||     .||..:::..|:.......:...|.:||.||:.  |.::....|....
Mouse   504 GNNRLKLGFGKS-----MPTNCVWLDGLSSNVSDQYLTRHFCRYGPVVKVVFDRLKGMALVLYSE 563

  Fly   129 VGDVQDAIKELNGRVVDGQPLKV-------QVSTSRVRPKPGM---------------------- 164
            :.|.|.|:||..||.:.|..:||       |::......|.|.                      
Mouse   564 IEDAQAAVKETKGRKIGGNKIKVDFANRESQLAFYHCMEKSGQDMRDFYEMLTERRAGQMAQSKH 628

  Fly   165 ----GDPEQCYRC--GRSGHWSKECPRLY-------GS---------AGGGREPPSPLSA--GGY 205
                .|.:..::|  .|.|.:.....|.|       |:         ...|||..|....  |.|
Mouse   629 EDWSADAQSPHKCREERRGSYEYSQERTYYENVRTPGTYPEDSRRDYPARGREFYSEWETYQGEY 693

  Fly   206 RDRMYGRDPYPPPPPPPPFLRDRIMDGFRDYDYYDR-------RFEDSRDLYERRYQTSRMRDFP 263
            .|..|    |..|.....:..|......|:|.|..|       |||..||...|..:.|:     
Mouse   694 YDSRY----YDEPREYREYRSDPYEQDIREYSYRQRERERERERFESDRDHERRPIERSQ----- 749

  Fly   264 PPPISRREPMP--LPPTLSGSLRSCSVSRGYDTMFSR----RSPPPPR----SSNGMSRYGSPTP 318
             .|:..|.|..  :.|..|..|.|.|..|.|.....|    .|..|||    ....:.||   |.
Mouse   750 -SPVHLRRPQSPGVSPAHSERLPSDSERRLYRRSSERSGSCSSVSPPRYDKLEKARLERY---TK 810

  Fly   319 HGYEDFSRDAFDERMISSR 337
            :...|..|....||:...|
Mouse   811 NEKADKERTFDPERVERER 829

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
larkNP_523957.1 RRM1_2_CoAA_like 8..73 CDD:409779 21/69 (30%)
RRM1_2_CoAA_like 87..152 CDD:409779 18/73 (25%)
hnRNP-R-Q <88..>258 CDD:273732 49/231 (21%)
SpenXP_006539132.1 RRM1_SHARP 7..81 CDD:240794
U2AF_lg 128..596 CDD:273727 45/161 (28%)
RRM2_SHARP 338..411 CDD:240795
RRM3_SHARP 438..511 CDD:240796 22/71 (31%)
RRM4_SHARP 512..588 CDD:240797 22/80 (28%)
PTZ00121 <635..1272 CDD:173412 51/208 (25%)
PHA03247 <1629..2063 CDD:223021
PHA03247 <2122..2642 CDD:223021
Collagen_mid <2641..>2722 CDD:374271
PHA03247 <2949..3474 CDD:223021
SPOC 3483..3642 CDD:369497
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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