DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lark and rbm4b

DIOPT Version :9

Sequence 1:	NP_523957.1	Gene:	lark / 38811	FlyBaseID:	FBgn0011640	Length:	352	Species:	Drosophila melanogaster
Sequence 2:	NP_989204.1	Gene:	rbm4b / 394812	XenbaseID:	XB-GENE-494431	Length:	338	Species:	Xenopus tropicalis

Alignment Length:	364	Identity:	132/364 - (36%)
Similarity:	179/364 - (49%)	Gaps:	69/364 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 KLFIGNLDEKTQATELRALFEKYGTVVECDVVKNYGFVHMETEQQGRDAIQNLNGYTLNEFAIKV 72
            |||:|||..:...:||::|||::|.|.|||::|||||||||..:...:|:.|||.|.|:...|.|
Frog     3 KLFVGNLPPEATQSELKSLFEQFGRVTECDIIKNYGFVHMEDRKAADEAVHNLNHYKLHSVPINV 67

  Fly    73 EAAKSRRAPNTPTTKIFVGNLTDKTRAPEVRELFQKYGTVVECDIVRNYGFVHLDCVGDVQDAIK 137
            |  .||..|.. :||:.|.||:....:.|:|..|::||.|:|||||::|.|||::...:..||||
Frog    68 E--HSRGKPKA-STKLHVSNLSTSCTSEELRAKFEEYGAVLECDIVKDYAFVHMERSAEALDAIK 129

  Fly   138 ELNGRVVDGQPLKVQVSTSRVRPKPGMGDPEQCYRCGRSGHWSKECP------RLYGSAGGGRE- 195
            .|:.....|:.:.||:||||:|..||||:..:|||||:.||||||||      .|..:.|...|
Frog   130 NLDNTEFKGKRMHVQLSTSRLRVTPGMGERTRCYRCGKEGHWSKECPLDQMTKELEQAPGYPPES 194

  Fly   196 ---PPSPL--SAGGYRDRMYGRDPYPPPPPPPPFLRDRIMDGFRDYDYYDR---RFEDSRDLYER 252
               |..|:  :|..||.....|..|..        |:|    |...|||.|   |......|.||
Frog   195 FPDPYGPMRSAAAAYRTAYAHRVFYDE--------RER----FSIVDYYQRYRVRPSSYDALIER 247

  Fly   253 RYQT-----------SRMRDFPPPPISRREPMPLPPTLSGSLRSCSVSRGYDTMFSRRSPPPPRS 306
            |...           .|:..||    ..|..:|.||.|..|            .:.|...|..||
Frog   248 RLTALPSAATTVSYRERIESFP----YERHLLPPPPELPSS------------YYPRERSPLRRS 296

  Fly   307 SNGMS--------RYGSPTPHG--YED--FSRDAFDERM 333
            |:..|        |..||....  .:|  .||:::.||:
Frog   297 SSASSSMEIYRTERRLSPIMRSPFVDDPRCSRESYYERV 335

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lark	NP_523957.1	RRM1_2_CoAA_like	8..73	CDD:409779	32/64 (50%)
		RRM1_2_CoAA_like	87..152	CDD:409779	25/64 (39%)
		hnRNP-R-Q	<88..>258	CDD:273732	70/195 (36%)
rbm4b	NP_989204.1	RRM_SF	2..68	CDD:388407	32/64 (50%)
		RRM_SF	78..144	CDD:388407	26/65 (40%)
		ZnF_C2HC	161..176	CDD:197667	11/14 (79%)
		COG5222	<162..>201	CDD:227547	17/38 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	72	1.000	Domainoid score	I9175
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	186	1.000	Inparanoid score	I3804
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1563362at2759
OrthoFinder	1	1.000	-	-		FOG0002310
OrthoInspector	1	1.000	-	-		oto102486
Panther	1	1.100	-	-	LDO	PTHR23147
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4630
SonicParanoid	1	1.000	-	-		X1736
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.100