DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lark and RBMS3

DIOPT Version :9

Sequence 1:	NP_523957.1	Gene:	lark / 38811	FlyBaseID:	FBgn0011640	Length:	352	Species:	Drosophila melanogaster
Sequence 2:	NP_001003793.1	Gene:	RBMS3 / 27303	HGNCID:	13427	Length:	437	Species:	Homo sapiens

Alignment Length:	262	Identity:	53/262 - (20%)
Similarity:	91/262 - (34%)	Gaps:	82/262 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LFIGNLDEKTQATELRALFEKYGTVVECDVV--------KNYGFVHMETEQQGRDAIQNL--NGY 63
            |:|..|...|...:|..|.:.||.:|....:        |.||||..::....:.|:.:|  ||
Human    63 LYIRGLPPGTTDQDLIKLCQPYGKIVSTKAILDKNTNQCKGYGFVDFDSPAAAQKAVASLKANG- 126

  Fly    64 TLNEFAIKVEAAKSRRAPNTPTTKIFVGNLTDKTRAPEVRELFQKYGTVVECDIVRN-------Y 121
                    |:|..:::....| |.:::.||.......|:..:.:.:|.|:...|:|:       .
Human   127 --------VQAQMAKQQEQDP-TNLYISNLPISMDEQELENMLKPFGHVISTRILRDANGVSRGV 182

  Fly   122 GFVHLDCVGDVQDAIKELNGRVVDGQPLKVQVSTSRVRPKPGMGDPEQCYRC------------- 173
            ||..::.....:..|:..||:.              ::..||:..|.:...|
Human   183 GFARMESTEKCEVVIQHFNGKY--------------LKTPPGIPAPSEPLLCKFADGGQKKRQNQ 233

  Fly   174 ------GRSGHWSKECPRLYGSAGGG--REPPSPLSAGGYRDRMYGRDPYP-------PPPPPPP 223
                  ||.  |.:|     |.||..  .:|.:.:..|.|      ..||.       |.....|
Human   234 SKYTQNGRP--WPRE-----GEAGMALTYDPTAAIQNGFY------SSPYSIATNRMIPQTSITP 285

  Fly   224 FL 225
            |:
Human   286 FI 287

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lark	NP_523957.1	RRM1_2_CoAA_like	8..73	CDD:409779	18/73 (25%)
		RRM1_2_CoAA_like	87..152	CDD:409779	12/71 (17%)
		hnRNP-R-Q	<88..>258	CDD:273732	31/173 (18%)
RBMS3	NP_001003793.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	28..57
		RRM1_RBMS3	57..136	CDD:409902	20/81 (25%)
		RRM2_RBMS3	139..226	CDD:240919	18/101 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	399..437
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910