DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lark and Pabpc4

DIOPT Version :9

Sequence 1:	NP_523957.1	Gene:	lark / 38811	FlyBaseID:	FBgn0011640	Length:	352	Species:	Drosophila melanogaster
Sequence 2:	NP_570951.2	Gene:	Pabpc4 / 230721	MGIID:	2385206	Length:	660	Species:	Mus musculus

Alignment Length:	416	Identity:	90/416 - (21%)
Similarity:	139/416 - (33%)	Gaps:	149/416 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 AGTFKLFIGNLDEKTQATELRALFEKYGTVVECDVV------KNYGFVHMETEQQGRDAIQNLNG 62
            :|...:||.|||:......|...|..:|.::.|.||      |.|.|||.||::....||:.:||
Mouse    96 SGVGNVFIKNLDKSIDNKALYDTFSAFGNILSCKVVCDENGSKGYAFVHFETQEAADKAIEKMNG 160

  Fly    63 YTLNEFAIKVEAAKSRR-------APNTPTTKIFVGNLTDKTRAPEVRELFQKYGTVVECDIVRN 120
            ..||:..:.|...|||:       |.....|.:::.|..::.....::|||.::|..:...::|:
Mouse   161 MLLNDRKVFVGRFKSRKEREAELGAKAKEFTNVYIKNFGEEVDDGNLKELFSQFGKTLSVKVMRD 225

  Fly   121 -------YGFVHLDCVGDVQDAIKELNGRVVDGQPLKV------------------QVSTSRVRP 160
                   :|||..:...|...|::|:||:.:.|:.:.|                  |:...|:..
Mouse   226 SSGKSKGFGFVSYEKHEDANKAVEEMNGKEMSGKAIFVGRAQKKVERQAELKRKFEQLKQERISR 290

  Fly   161 KPGMG----------DPEQCYR----------------CGRSGHWSKEC---------------P 184
            ..|:.          |.|:..|                .|||..:...|               .
Mouse   291 YQGVNLYIKNLDDTIDDEKLRREFSPFGSITSAKVMLEDGRSKGFGFVCFSSPEEATKAVTEMNG 355

  Fly   185 RLYGS--------------------------AGGGREPPSPL------SAGGY----RDRMYGRD 213
            |:.||                          ||....|.|.:      :||||    ..:..||.
Mouse   356 RIVGSKPLYVALAQRKEERKAHLTNQYMQRVAGMRALPASAILNQFQPAAGGYFVPAVPQAQGRP 420

  Fly   214 PYPPP------PPPPPFLRDRIMDGFRDYDYYDRRFEDSRDLYERRYQTSRMRDFPPPPISRREP 272
            ||..|      .|.|.:.:.....||:.                   ..|.:|...|.|..|.
Mouse   421 PYYTPNQLAQMRPNPRWQQGGRPQGFQG-------------------MPSALRQSGPRPALRH-- 464

  Fly   273 MPLPPTLSGSLRSCSVSRGYDTMFSR 298
              |.||     .:...|||..|...|
Mouse   465 --LAPT-----GNAPASRGLPTTAQR 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lark	NP_523957.1	RRM1_2_CoAA_like	8..73	CDD:409779	24/70 (34%)
		RRM1_2_CoAA_like	87..152	CDD:409779	16/89 (18%)
		hnRNP-R-Q	<88..>258	CDD:273732	46/277 (17%)
Pabpc4	NP_570951.2	PABP-1234	11..640	CDD:130689	90/416 (22%)
		RRM1_I_PABPs	12..91	CDD:240824
		RRM2_I_PABPs	97..172	CDD:240825	26/74 (35%)
		RRM3_I_PABPs	190..269	CDD:240826	17/78 (22%)
		RRM4_I_PABPs	293..370	CDD:240827	11/76 (14%)
		PABP	572..639	CDD:279051
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910