DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lark and RBM34

DIOPT Version :9

Sequence 1:	NP_523957.1	Gene:	lark / 38811	FlyBaseID:	FBgn0011640	Length:	352	Species:	Drosophila melanogaster
Sequence 2:	NP_055829.2	Gene:	RBM34 / 23029	HGNCID:	28965	Length:	430	Species:	Homo sapiens

Alignment Length:	218	Identity:	46/218 - (21%)
Similarity:	81/218 - (37%)	Gaps:	57/218 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LFIGNLDEKTQATELRALFEKYGTV-------------------------VECDVVKNYGFVHME 48
            :|:|||.......:|::.|::||.:                         :..|......:|..:
Human   187 VFVGNLPVTCNKKKLKSFFKEYGQIESVRFRSLIPAEGTLSKKLAAIKRKIHPDQKNINAYVVFK 251

  Fly    49 TEQQGRDAIQNLNGYTLNEFAIKVEAAKSRRAPNTPTTKIFVGNLTDKTRAPEVRELFQKYGTVV 113
            .|.....|::.......:.|.|:|:.|.  ...:.....:|||||..|.....:.:.|...|:::
Human   252 EESAATQALKRNGAQIADGFRIRVDLAS--ETSSRDKRSVFVGNLPYKVEESAIEKHFLDCGSIM 314

  Fly   114 ECDIVRN--------YGFVHLDCVGDVQDAIK----ELNG------RVVDGQPLKVQVSTSRV-- 158
            ...|||:        :|:|..:....|..|:|    ||.|      |.|:.:..|.|.|..|:
Human   315 AVRIVRDKMTGIGKGFGYVLFENTDSVHLALKLNNSELMGRKLRVMRSVNKEKFKQQNSNPRLKN 379

  Fly   159 --RPKPGM--------GDPEQCY 171
              :||.|:        |.|:..:
Human   380 VSKPKQGLNFTSKTAEGHPKSLF 402

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lark	NP_523957.1	RRM1_2_CoAA_like	8..73	CDD:409779	14/88 (16%)
		RRM1_2_CoAA_like	87..152	CDD:409779	22/82 (27%)
		hnRNP-R-Q	<88..>258	CDD:273732	30/114 (26%)
RBM34	NP_055829.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..55
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	72..123
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	134..153
		RRM	176..>382	CDD:223796	41/196 (21%)
		RRM1_RBM34	185..276	CDD:240840	14/88 (16%)
		RRM2_RBM34	288..360	CDD:240841	19/71 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	365..395		7/29 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	411..430
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910