DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lark and Rbm15b

DIOPT Version :9

Sequence 1:	NP_523957.1	Gene:	lark / 38811	FlyBaseID:	FBgn0011640	Length:	352	Species:	Drosophila melanogaster
Sequence 2:	NP_780611.3	Gene:	Rbm15b / 109095	MGIID:	1923598	Length:	887	Species:	Mus musculus

Alignment Length:	380	Identity:	93/380 - (24%)
Similarity:	136/380 - (35%)	Gaps:	110/380 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 TFKLFIGNLDEKTQATELRALFEKYGTVVECDVVKN--------YGFVHMETEQQGRDAIQNLNG 62
            |..|||||||......|||..||||| ::|..|:|.        |.|:..:.......|...::|
Mouse   332 TRNLFIGNLDHSVSEVELRRAFEKYG-IIEEVVIKRPARGQGGAYAFLKFQNLDMAHRAKVAMSG 395

  Fly    63 YTLNEFAIKVEAAKSRRAPNTPTTKIFVGNLTDKTRAPEVRELFQKYGTVVECDIVR--NYGFVH 125
            ..:....||:...|:     .|||:::||.|...|....:...|.::|::...|.|:  ::.::.
Mouse   396 RVIGRNPIKIGYGKA-----NPTTRLWVGGLGPNTSLAALAREFDRFGSIRTIDHVKGDSFAYIQ 455

  Fly   126 LDCVGDVQDAIKELNGRVVDGQPLKVQVSTSRVRPKPGMGDPEQCYRCGRSGHWSKECPRLYGSA 190
            .:.:...|.|..::.|..:.|...:::|..::..        |..|            |:.|
Mouse   456 YESLDAAQAACAKMRGFPLGGPDRRLRVDFAKAE--------ETRY------------PQQY--- 497

  Fly   191 GGGREPPSPLS------AGGY-RDRMYGRDPYPPPPPPPPFL---RDRIMDGFRDYDY------Y 239
                 .||||.      ..|| |.|....|.......||..|   |||.   |.:.|:      .
Mouse   498 -----QPSPLPVHYELLTDGYTRHRNLDADLRVRDRTPPHLLYSDRDRT---FLEGDWTSLSKSS 554

  Fly   240 DRRFEDSRDLYER--------RYQTSRMRDFPPPPISRREPMPLPPTLSGSLRSCSVSRGYDT-- 294
            |||  :|.:.|.|        |:.....|....|...||:           .||.|..||..|
Mouse   555 DRR--NSLEGYSRSVRSRSGERWGGDGDRSIAKPWEERRK-----------RRSLSSDRGRTTHS 606

  Fly   295 ----------------MFSRRSPPPPR----SSNGMSRYG----SPTPHGYEDFS 325
                            ..|.|:|...|    ||.|....|    |.:.||.|:.|
Mouse   607 PYEERSRTKGGGQQSERGSDRTPERSRKENHSSEGTKESGSNSLSNSRHGAEERS 661

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lark	NP_523957.1	RRM1_2_CoAA_like	8..73	CDD:409779	24/72 (33%)
		RRM1_2_CoAA_like	87..152	CDD:409779	12/66 (18%)
		hnRNP-R-Q	<88..>258	CDD:273732	41/195 (21%)
Rbm15b	NP_780611.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..132
		RRM1_RBM15B	134..215	CDD:240998
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	215..249
		RRM2_RBM15B	325..409	CDD:241000	25/77 (32%)
		RRM3_RBM15B	412..487	CDD:241002	16/74 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	549..703		30/126 (24%)
		SR-25	568..>712	CDD:287471	24/105 (23%)
		Nuclear localization signal. /evidence=ECO:0000255	590..594		2/14 (14%)
		Interaction with Epstein-Barr virus BMLF1. /evidence=ECO:0000250	719..887
		SPOC	719..854	CDD:285043
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910