DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lark and RBM14

DIOPT Version :9

Sequence 1:	NP_523957.1	Gene:	lark / 38811	FlyBaseID:	FBgn0011640	Length:	352	Species:	Drosophila melanogaster
Sequence 2:	NP_006319.1	Gene:	RBM14 / 10432	HGNCID:	14219	Length:	669	Species:	Homo sapiens

Alignment Length:	392	Identity:	112/392 - (28%)
Similarity:	161/392 - (41%)	Gaps:	112/392 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 KLFIGNLD-EKTQATELRALFEKYGTVVECDVVKNYGFVHMETEQQGRDAIQNLNGYTLNE-FAI 70
            |:|:||:| ..|...||.|||..||||:.|.|:|.:.||||........||:.|:|:.|.. .|:
Human     2 KIFVGNVDGADTTPEELAALFAPYGTVMSCAVMKQFAFVHMRENAGALRAIEALHGHELRPGRAL 66

  Fly    71 KVEAAKSRRAPNTP--TTKIFVGNLTDKTRAPEVRELFQKYGTVVECDIVRNYGFVHLDCVGDVQ 133
            .||.::.|     |  |.||||||::....:.|:|.||::.|.|:|||:|::|.|||::...|.:
Human    67 VVEMSRPR-----PLNTWKIFVGNVSAACTSQELRSLFERRGRVIECDVVKDYAFVHMEKEADAK 126

  Fly   134 DAIKELNGRVVDGQPLKVQVSTSRVR-------------PKPGMGDPEQCYRCGRSGHWSKECPR 185
            .||.:|||:.|.|:.:.|::||...:             .|||.||.......|.|..:.
Human   127 AAIAQLNGKEVKGKRINVELSTKGQKKGPGLAVQSGDKTKKPGAGDTAFPGTGGFSATFD----- 186

  Fly   186 LYGSAGGGREPPSPLSAGGYRDRMYGRDPYPPPPPPPPFLRDRIMDGFRDYDYYDRRFEDSRDLY 250
             |..|.|.       |.||:       |.....|.||.|.|||
Human   187 -YQQAFGN-------STGGF-------DGQARQPTPPFFGRDR---------------------- 214

  Fly   251 ERRYQTSRMRDFPP-----------PPISRREPMPLPPTLSGSLR---SCSVSRGYDTM------ 295
                  |.:|..||           |...|.:|   ..:|..:.|   |.|:..||.|.
Human   215 ------SPLRRSPPRASYVAPLTAQPATYRAQP---SVSLGAAYRAQPSASLGVGYRTQPMTAQA 270

  Fly   296 FSRRSPP------PPR-----------SSNGMSRYG--SPTPHGYEDFSRDAFDERMISSRGMRG 341
            .|.|:.|      |.|           :::.:..||  .|:......:...|.....::|.|.:|
Human   271 ASYRAQPSVSLGAPYRGQLASPSSQSAAASSLGPYGGAQPSASALSSYGGQAAAASSLNSYGAQG 335

  Fly   342 PS 343
            .|
Human   336 SS 337

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lark	NP_523957.1	RRM1_2_CoAA_like	8..73	CDD:409779	28/66 (42%)
		RRM1_2_CoAA_like	87..152	CDD:409779	28/64 (44%)
		hnRNP-R-Q	<88..>258	CDD:273732	51/182 (28%)
RBM14	NP_006319.1	RRM1_CoAA	1..71	CDD:241052	30/68 (44%)
		PABP-1234	<3..280	CDD:130689	101/332 (30%)
		RRM2_CoAA	79..146	CDD:241053	29/66 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	147..175		7/27 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	193..232		15/80 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	284..303		2/18 (11%)
		TRBP-interacting domain, interaction with STIL. /evidence=ECO:0000269\|PubMed:25385835	307..354		6/31 (19%)
		PRK13875	<319..433	CDD:237537	5/19 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	566..590
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0109
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1563362at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23147
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	5	4.880