DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lark and Gm21992

DIOPT Version :9

Sequence 1:	NP_523957.1	Gene:	lark / 38811	FlyBaseID:	FBgn0011640	Length:	352	Species:	Drosophila melanogaster
Sequence 2:	NP_001277056.1	Gene:	Gm21992 / 102902673	MGIID:	5439461	Length:	477	Species:	Mus musculus

Alignment Length:	333	Identity:	115/333 - (34%)
Similarity:	170/333 - (51%)	Gaps:	44/333 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 KLFIGNLDEKTQATELRALFEKYGTVVECDVVKNYGFVHMETEQQGRDAIQNLNGYTLNEFAIKV 72
            |||||||..:....|:|:|||:||.|:|||::|||||||:|.:....|||:||:.|.|:...|.|
Mouse   119 KLFIGNLPREATEQEIRSLFEQYGKVLECDIIKNYGFVHIEDKTAAEDAIRNLHHYKLHGVNINV 183

  Fly    73 EAAKSRRAPNTPTTKIFVGNLTDKTRAPEVRELFQKYGTVVECDIVRNYGFVHLDCVGDVQDAIK 137
            ||:|::   :..:||:.|||::......|:|..|::||.|:|||||::|.|||::...|..:||:
Mouse   184 EASKNK---SKASTKLHVGNISPTCTNQELRAKFEEYGPVIECDIVKDYAFVHMERAEDAVEAIR 245

  Fly   138 ELNGRVVDGQPLKVQVSTSRVRPKPGMGDPEQCYRCGRSGHWSKECP-----------RLYGSAG 191
            .|:.....|:.:.||:||||:|..|||||...|||||:.||||||||           ..|....
Mouse   246 GLDNTEFQGKRMHVQLSTSRLRTAPGMGDQSGCYRCGKEGHWSKECPIDRSGRVADLTEQYNEQY 310

  Fly   192 GGREPPSPLSAGGYRDRMYGRDPYPPPPPPPPFLRDRIMDGFRDYDYYDRRFEDSRDLYE--RRY 254
            |....|..:|   |.|.:|..:.|..                  .|.|.:|...:|. ||  ...
Mouse   311 GAVRTPYTMS---YGDSLYYNNTYGA------------------LDAYYKRCRAARS-YEAVAAA 353

  Fly   255 QTSRMRDFPPPPISRREPMPLPPTLSGSLRSCSVSRGYDTMFSRRSPPPPRSSNGMSRYGSPTPH 319
            ..|...::....:|:     ||...:.::.|...|...|. ::|...||..::...:...:.|..
Mouse   354 AASAYSNYAEQTLSQ-----LPQVQNTAMASHLTSTSLDP-YNRHLLPPSGAAAAAAAAAACTAA 412

  Fly   320 GYEDFSRD 327
            ....:.||
Mouse   413 STSYYGRD 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lark	NP_523957.1	RRM1_2_CoAA_like	8..73	CDD:409779	34/64 (53%)
		RRM1_2_CoAA_like	87..152	CDD:409779	24/64 (38%)
		hnRNP-R-Q	<88..>258	CDD:273732	62/182 (34%)
Gm21992	NP_001277056.1	RRM1_CoAA	1..71	CDD:241052
		ELAV_HUD_SF	14..265	CDD:273741	67/148 (45%)
		RRM_SF	79..184	CDD:302621	34/64 (53%)
		RRM1_RBM4	118..184	CDD:241050	34/64 (53%)
		RRM2_RBM4	194..260	CDD:241051	25/65 (38%)
		ZnF_C2HC	277..292	CDD:197667	11/14 (79%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0109
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1563362at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104638
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4630
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840