DRSC/TRiP Functional Genomics Resources

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Protein Alignment mus312 and SLX4

DIOPT Version :9

Sequence 1:NP_729234.2 Gene:mus312 / 38809 FlyBaseID:FBgn0002909 Length:1149 Species:Drosophila melanogaster
Sequence 2:NP_115820.2 Gene:SLX4 / 84464 HGNCID:23845 Length:1834 Species:Homo sapiens


Alignment Length:1281 Identity:244/1281 - (19%)
Similarity:409/1281 - (31%) Gaps:453/1281 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 FKNLQPRLTRSTKAA-----ADTLSLSNFFATPENAEEVP-SCLADIPVQPD-PPAPKIKPI--- 64
            |...|.:|.:..:||     ||.|         |....|. ..||.:.||.. ....:::|:   
Human   857 FAATQRKLLQEERAAGAGEDADWL---------EGGSPVSGQLLAGVQVQKQWDKVEEMEPLEPG 912

  Fly    65 --RTSNVFEKPG----PKPK---------KAPKLKA----------STVSTSSGARRGRGKSKQQ 104
              ..:..:||.|    |.|:         :||:.:|          |:.|....|.|..|.....
Human   913 RDEAATTWEKMGQCALPPPQGQHSGARGAEAPEQEAPEEALGHSSCSSPSRDCQAERKEGSLPHS 977

  Fly   105 PSISNFLRNEQIFAEVTAQHCMADNFSADDIEMALALSKSESEKHGRL-----------RLHDDD 158
            ....::   ||:|:....:.......:::..|.:.|:.:...|...||           |.    
Human   978 DDAGDY---EQLFSSTQGEISEPSQITSEPEEQSGAVRERGLEVSHRLAPWQASPPHPCRF---- 1035

  Fly   159 DAVVDLLDDEEKSTERIRHKLQKYGFRTAAKEDYKSLAVLPVVASKGGRRGKWANRFTSLTLRNP 223
                 ||...:..:.|..|              :.|.:.|....|:||     .::..|.||.:|
Human  1036 -----LLGPPQGGSPRGSH--------------HTSGSSLSTPRSRGG-----TSQVGSPTLLSP 1076

  Fly   224 DVQQKKLEEKVSALLGQE---MRGKEPNGEDCCLTPYTVITAALKELRAEGESRILREPSEGPID 285
            .|..|:..::....|.:|   .:|||              ..::.|.|.:|   :|..|.:.|..
Human  1077 AVPSKQKRDRSILTLSKEPGHQKGKE--------------RRSVLECRNKG---VLMFPEKSPSI 1124

  Fly   286 DLESYYVTDLFEVSRTPAHHLLKNWAAIQGRDFSPERETQKCRQLRQQHELVY-----AELERYY 345
            ||          ....|.|              |..|..:...:|.::.|::.     .|||   
Human  1125 DL----------TQSNPDH--------------SSSRSQKSSSKLNEEDEVILLLDSDEELE--- 1162

  Fly   346 GDPQKLEEEVMQEL--DELEKLVADNMIEDDSVVINIVEAESSSTGSSPSKEPPDKRPKMTMEDK 408
                 ||:..|:.:  |.||:..|..:......:.:|::.::.   ..||:.||.....:..||:
Human  1163 -----LEQTKMKSISSDPLEEKKALEISPRSCELFSIIDVDAD---QEPSQSPPRSEAVLQQEDE 1219

  Fly   409 ENLQPTTSKASLTVPAQSTRCTSPDLFADSEDEPDIVTTAISNEPEDVRNLSMKVYKNVSISERS 473
            ..|  ..::.||      .|..:|.||.|.|..|                      ...|.::.|
Human  1220 GAL--PENRGSL------GRRGAPWLFCDRESSP----------------------SEASTTDTS 1254

  Fly   474 SSVAEIEIVS-SNDEPSQITTYEVFSSDEVKTVSNATQEKISFDDKPIDDFIDLTQEFDMVEFNE 537
            ..|....:.| |.|..||.....:.|...|:.|:..| .:.|..::   :..::.|:|.::....
Human  1255 WLVPATPLASRSRDCSSQTQISSLRSGLAVQAVTQHT-PRASVGNR---EGNEVAQKFSVIRPQT 1315

  Fly   538 SKPRTPNLIASSETDSNVDNLNGDTILDFSSQEVSC--PISKELYAKYAKVETFPVWNAAAEEED 600
            ..|:||:                           ||  |:|.                       
Human  1316 PPPQTPS---------------------------SCLTPVSP----------------------- 1330

  Fly   601 KIEFSLSMERDLKSSEQSSHQLGILTTPNDTEHSS-------SFSELNFSRNSLRRSVSLSTDLS 658
                      ......:..|:......|....|||       |....:|||..|:.|        
Human  1331 ----------GTSDGRRQGHRSPSRPHPGGHPHSSPLAPHPISGDRAHFSRRFLKHS-------- 1377

  Fly   659 FKSPLNWKMNSSAEKRVSPAASPYKQSDA-SVDLTQNSDDENDAILLSDEEINYSIWKGNKTVKD 722
                             .|..|...|:.| .|....:||||.:   ::..:.|.|      ...|
Human  1378 -----------------PPGPSFLNQTPAGEVVEVGDSDDEQE---VASHQANRS------PPLD 1416

  Fly   723 LDIGDDSSDSCF----ASPVTKKRAIPQFQTEEDLDAFLMDFSTDGNGSQGSHSPNKSALSKERA 783
            .|......|.|:    .||:             .:|.:.::.:...:.|..|...|::|.|::..
Human  1417 SDPPIPIDDCCWHMEPLSPI-------------PIDHWNLERTGPLSTSSPSRRMNEAADSRDCR 1468

  Fly   784 EFGILDAAPSQPFSLSELQSHADKEKSSD-NEINWAEASFLDAPAKPLSRRSSHKFNELLAKISK 847
            ..|:||..|.:....::.:.   :||||. ..:..:..|||                        
Human  1469 SPGLLDTTPIRGSCTTQRKL---QEKSSGAGSLGNSRPSFL------------------------ 1506

  Fly   848 PAHNSG--DDFDEFDQMVFQSTKEAASSAGETSDMPQGLDLLLKGEIKTTAIPETRAPGNQTPIE 910
               ||.  |.:|..:|...::...|...:...:..|:||              ||....|:....
Human  1507 ---NSALWDVWDGEEQRPPETPPPAQMPSAGGAQKPEGL--------------ETPKGANRKKNL 1554

  Fly   911 PQQVDVDGNVYSVRVCHTPKPDFATLPESEILQQLYKYGIKPLKRKQAVKMLEFIYNQTHPIMKT 975
            |.:|.:           ||.|.::.:....:.::|.::|::||.::|.|..|:.|:..||     
Human  1555 PPKVPI-----------TPMPQYSIMETPVLKKELDRFGVRPLPKRQMVLKLKEIFQYTH----- 1603

  Fly   976 AAVQDLPARSEPIVRSKSTPVIMERPHSQ-VAKSTSKTLKA-IGTKKDLTFNDATG--------- 1029
               |.|.:.||.  .|:|:..:::.||.| :|..|.|..:| :..:::.|    ||         
Human  1604 ---QTLDSDSED--ESQSSQPLLQAPHCQTLASQTYKPSRAGVHAQQEAT----TGPGAHRPKGP 1659

  Fly  1030 -------------EELLRFSQS----LAPSLCDDFETFVMQTNVTK------------------- 1058
                         |.:...|:|    ..|.|.||.:....|.:|..                   
Human  1660 AKTKGPRHQRKHHESITPPSRSPTKEAPPGLNDDAQIPASQESVATSVDGSDSSLSSQSSSSCEF 1724

  Fly  1059 ----------------KTPQPLVPLHIAWHNLIC---ANPQLHESVLTYEPIDLQAVYLHLKHMG 1104
                            ...|..|........|.|   :.|.|::.||.|:|.:|:.:...|:..|
Human  1725 GAAFESAGEEEGEGEVSASQAAVQAADTDEALRCYIRSKPALYQKVLLYQPFELRELQAELRQNG 1789

  Fly  1105 HRYDPKDLKTFFDRRCIIF------RYELGAPGKQAERHVRRHTKK 1144
            .|...:.|..|.|..||.|      |.:|     |..|...|..||
Human  1790 LRVSSRRLLDFLDTHCITFTTAATRREKL-----QGRRRQPRGKKK 1830

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mus312NP_729234.2 Slx4 1068..1125 CDD:286569 18/65 (28%)
SLX4NP_115820.2 Interaction with SLX4IP, ERCC4/XPF and MSH2. /evidence=ECO:0000269|PubMed:19596235 1..669
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 24..49
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 69..206
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 376..417
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 452..471
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 561..610
BTB 681..788 CDD:321966
Interaction with PLK1 and TERF2-TERF2IP. /evidence=ECO:0000269|PubMed:19596235 684..1834 244/1281 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 826..846
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 902..1151 56/320 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1195..1504 80/455 (18%)
Interaction with MUS81 1328..1648 86/464 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1516..1564 12/72 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1605..1746 25/146 (17%)
Interaction with SLX1 1632..1834 42/208 (20%)
Slx4 1754..1810 CDD:312858 18/55 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0006963
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - LDO PTHR21541
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R9004
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
33.130

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