DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mus312 and slx4

DIOPT Version :9

Sequence 1:	NP_729234.2	Gene:	mus312 / 38809	FlyBaseID:	FBgn0002909	Length:	1149	Species:	Drosophila melanogaster
Sequence 2:	XP_002932505.2	Gene:	slx4 / 100379741	XenbaseID:	XB-GENE-981723	Length:	1695	Species:	Xenopus tropicalis

Alignment Length:	1518	Identity:	290/1518 - (19%)
Similarity:	497/1518 - (32%)	Gaps:	435/1518 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KTRRANFKNLQPRLTRSTKAAADTLSLSNFFATPENAEEVPSCLADI-------PVQPDPPAPK- 60
            |:|.::.|    |.....:..|.||..:....|.|:..|..:|:...       |.:.:||..|
Frog   239 KSRASHLK----RCAAQLEVPAHTLLQAVQRQTTESVTEAATCVVSAKAKRKAGPKKKEPPKKKK 299

  Fly    61 -IKP----------IRTSNVFEKPGPKP------KKAPKLKASTVSTSSGARRGRGKSKQQP--- 105
             ::|          :..|...::....|      |..|..|:|...     ::.|.|.|..|
Frog   300 MVQPNSEVEDLLVAMALSRSLQEDPTTPMCEIAQKAVPATKSSVPE-----KKSRKKQKNAPPPL 359

  Fly   106 -----SISNFLRNEQIFAEVTAQHCMADNFSADDIEMALALSKSESEKHGRLR-LHDDDDAVV-- 162
                 ..:.|.|.:|..|.:.::.  .:..|...:..:...|.:|.|||...| |.|.....:
Frog   360 LLVQAPEAAFQRLQQRVAILLSEE--LELISNTALPQSWLSSIAEKEKHAWWRPLQDKQICTLWE 422

  Fly   163 --DLLDDEEKSTERI--------------RHKLQKYGFRTA------------------------ 187
              :::|:.:.....|              :|||.....||.
Frog   423 GSNMMDNRDLLGYYIQELNPPITPWKPPAQHKLYNSQPRTVTPVHLAATPPCSVSSAKQQSTETC 487

  Fly   188 ---------AKEDYKSLAVLPVVASKGGRRGKWA--------NR----FTSLTLRN--PDVQQKK 229
                     :::|.::|..|..:|.:|....:|.        ||    .:|:|...  |.:|::.
Frog   488 SQDGHLLSHSQKDRQALLDLAELAGEGMTLTQWKLGTSHEVDNRGRESVSSVTASGFVPSLQEET 552

  Fly   230 LEE----KVSALL------GQEMRGKEPNGE-----DC--CLTPYTVITAA-------------- 263
            .::    ::||.|      ..||.......:     ||  .|:.:..:..|
Frog   553 CKQSDHPQLSAPLVSLAADFMEMVNNPHLSDAQLQTDCGEVLSVHMFVLYARCPLLVEAVHSEGF 617

  Fly   264 --------------LKELRAEGESRILR----EPSEGPIDDL-------ESYYVTDLFEVSRTPA 303
                          |.::.||.....||    ..|..||..|       ..:.|:.|.||    .
Frog   618 WVDEAGTGRVRRLLLNDVSAEAALCFLRFLYSASSTIPIHCLTHVCELARRFGVSSLIEV----C 678

  Fly   304 HHLLKNWAAIQGRDFSPERE-----------TQKCRQLRQQHELVYAELERYYGDPQKLEEEVMQ 357
            .||:......:..|.:.|.|           .:..:.:....:...||||.......|||.|.:.
Frog   679 EHLVSEPENSETLDAAAEEEDDDGGMRAETFQELLKSMWVDEDEGVAELETEGQGEDKLEAEAVG 743

  Fly   358 E--LDELEKLVA--------DNMIEDDSVVINIVEAESSSTGSSPSKEPPDKRPK-MTMEDKENL 411
            |  |:|:.:..|        .:..:..|..:::...||..:......||....|. .:.|..:..
Frog   744 ECDLEEIYEFAATQRRVTGKQDTQDGSSSELDMQNQESEDSALGERNEPERLVPSGPSTEYNKQT 808

  Fly   412 QPTTSKASLTVPAQSTRC-------TSPDLFADSEDEPDIVTTAISNEPE---DVRNLSMKVYKN 466
            ....|..::|:||....|       :||             |....:.|.   .|.:.|:|
Frog   809 HTRASVPNVTIPATQQPCLAKVSPVSSP-------------TGTPKSHPSFSPSVSHSSLK---- 856

  Fly   467 VSISER----------------SSSVAEIEIVSSNDEPSQITTYEVFSSDEVKTVSNATQEK-IS 514
            .|.|:|                ::||.. |.:|.....|...|..|.:|.....|:.|.|:. |.
Frog   857 PSCSQRLLSTSGCHASPAGNLFANSVLS-EHLSPTSAESAGPTAGVVASISPSRVNEAEQDLFIQ 920

  Fly   515 FDDKPIDD------------FIDLTQEFDMVEFNE----SKPRTPNLIASSETDSNVDNLNGDTI 563
            .:..|:||            :::|:.....|:..|    |.|.|..|....|..|: .||....:
Frog   921 RNPLPLDDSYDRMFSETCGEYVELSDTVIPVQNQEHTLTSPPTTTVLPVLPELGSS-PNLQHSPL 984

  Fly   564 LDFSSQEVSCPISKELYAKYAKVETFPV--WNAAAEEED------------KIEFSLSMERD--- 611
               :|....|.| |.:.|  |:..:||:  .|::....|            ...|:.|.|.|
Frog   985 ---NSDNSPCKI-KGVTA--AEPRSFPLCSLNSSRNSHDSDSFHNPTNHTTSSSFAKSQEPDVIL 1043

  Fly   612 -LKSSEQSSHQLGILTTPNDT------------EHSSSFSELNFSRNSLRRSVSLSTDLSFKSPL 663
             |.|.|::...:..|.:|...            |...|||....|..|....:|.|.:.|:..|.
Frog  1044 ILSSDEETEPNMEGLLSPGSVHEGKDCILNGIKESPVSFSIKRRSEGSSNLEMSSSMETSWLVPA 1108

  Fly   664 N------------------------------WKMNSSAEKRVSPAASPYKQSDASV----DLTQN 694
            .                              :..||.:...:|||.||.|.....|    .|||.
Frog  1109 TPLPQTVLSVVSRLQTSCLPEVPQISTIQSAFHYNSLSPPLLSPAKSPAKPLSPPVSPDLQLTQG 1173

  Fly   695 SDDENDAILLSDEEINY---SIWKGNKTVKDLDIGDDSSDSCFASPVTKKRAIPQFQTEEDLDAF 756
            |....:....|..:.::   |:.....:...:::| ||.|.|   |:.|.:......:......|
Frog  1174 SAQLPEVCRSSGSKASFAPSSLPASPTSSSVVEVG-DSEDEC---PIPKGQLGSPAASASHQSPF 1234

  Fly   757 LMDFST-DGNGSQGSHSPNKSALS---------------------KERAEFGILDAAPSQPFSLS 799
              .|.| ..|.|:.|:.|....||                     |......:| |:|:.. |:.
Frog  1235 --HFKTLSNNLSESSNEPMIPQLSPTTRPTQDPVPLLEPCDNVDTKTSPAHSLL-ASPASS-SVI 1295

  Fly   800 ELQSHADKEKSSDNEINWAEASFL------------------DAPAK---------PLSRRSSHK 837
            |:::..|....::..:..:..||.                  :.|.:         |.|..|:.|
Frog  1296 EIENIQDGSPQTEVRLGTSGYSFYIDYEPPIPVEDDLWFHGEETPKRPDPSPKTCTPPSIESTPK 1360

  Fly   838 FNELLAKISKPAHNSGDDFDE------FDQMVFQSTKEAASSAGETSDMPQGLDLLLKGEIKTTA 896
            ...::...|.|...|.....|      ..::.|.:|:.......|..|:|..|.|..:
Frog  1361 KEAVVQNSSTPHRGSPAPLREDGSVPHSSRLSFLNTQTWEEWEEEEEDLPAVLPLSER------- 1418

  Fly   897 IPETRAPGNQTPIEPQQVDVDGNVYSVRVCHTPKPDFATLPESEILQQLYKYGIKPLKRKQAVKM 961
              .::||.:|..::.....|.....:.:|..||.|.::.:....:.::|.::|::.|.:||.|..
Frog  1419 --LSKAPESQKQLKTPVSIVRKRELAPKVPITPLPAYSDMDTPILKKELNRFGVRALPKKQMVLK 1481

  Fly   962 LEFIYNQTHPIMKTAAVQDLPAR-------------SEPIVRSKSTPVIMERPHSQVAKSTSKTL 1013
            |:.|::.||.:|.:.:.:::|::             ..|:..........:.|.|..|....|..
Frog  1482 LKEIFSYTHQVMSSDSDEEVPSQLNRGGNGNKAPIHKPPVANKPKQSASAQGPVSSQAHKPRKAA 1546

  Fly  1014 KAIGTKKDLTFNDATGEELLRFSQ------------SLAP-SLCDDFETFVMQTNVTKKTPQPL- 1064
            .....|.....::...|:.|..||            ||:. |..::|||........:..|...
Frog  1547 SVCNAKASTQEHNMGSEQRLNASQESTTSSGGSDTSSLSQGSAANEFETAFADEEEDEPVPASQE 1611

  Fly  1065 ----VPLHIAWHNLICANPQLHESVLTYEPIDLQAVYLHLKHMGHRYDPKDLKTFFDRRCIIFRY 1125
                .....|....|.::|.|::.:|.|:|::|.|::..||..|.:.....|..|.|..||.|..
Frog  1612 VGREAATAEAVKRFIESHPDLYKRILLYQPLELAALHAELKQAGIKVASGKLLDFLDTHCITFTT 1676

  Fly  1126 ELGAPGKQAERHVRRHTKKPSKR 1148
            ......|.::|.     :|..||
Frog  1677 AAARKEKTSKRR-----RKAGKR 1694

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mus312	NP_729234.2	Slx4	1068..1125	CDD:286569	18/56 (32%)
slx4	XP_002932505.2	BTB_POZ_BTBD12_SLX4	564..679	CDD:349597	20/118 (17%)
		PHA03247	<1144..1271	CDD:223021	30/132 (23%)
		Slx4	1619..1676	CDD:401446	18/56 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006963
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR21541
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9004
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.130