DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mrva and VBA5

DIOPT Version :9

Sequence 1:	NP_001261505.1	Gene:	mrva / 38808	FlyBaseID:	FBgn0035763	Length:	478	Species:	Drosophila melanogaster
Sequence 2:	NP_013031.3	Gene:	VBA5 / 853980	SGDID:	S000001813	Length:	582	Species:	Saccharomyces cerevisiae

Alignment Length:	555	Identity:	108/555 - (19%)
Similarity:	183/555 - (32%)	Gaps:	162/555 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 DEERIVDNEEVSRPTEEDQVVSRAGRRDNELSLPSGGCCMPSSTSHRFMALVFMCLLG------- 62
            :|.:....:|:......|..::..|..|:.:.| |...|:.|.|...|:..:.:.::|
Yeast     2 EETKYSSQQEIEGACGSDASLNARGSNDSPMGL-SLYLCLASLTLVLFITALDILIVGTIIDVVA 65

  Fly    63 --FGSYFCYDAPGALQNYFKKDLNLTSAQFTLIYSIYSWPNVVLCFVGGFLIDRLFGIRLGTIIY 125
              ||            ||.|....:|.         ||.||.:|..:.|.... :.|.:...|:.
Yeast    66 EQFG------------NYSKTGWLVTG---------YSLPNAILSLIWGRFAS-IIGFQHSLILA 108

  Fly   126 MMILLVGQLIFACGGILDAFWMMILGRFIFGIGAESLAVAQNSYAVLWFKGKELNMVFGLQLSVA 190
            ::|...|.||.|....::   |:|.||.:.|:|..                       |||....
Yeast   109 ILIFEAGSLIAALASSMN---MLIFGRVVAGVGGS-----------------------GLQTLCF 147

  Fly   191 RFGSTVNFWVMQP-IYEYVSNFYKGHTALGVVLLLATLTCVMSMTC----------ALILGWMDK 244
            ..|.|:.....:| :...:|..:.....:|.::..|..|.|....|          |:|:..:..
Yeast   148 VIGCTMVGERSRPLVISILSCAFAVAAIVGPIIGGAFTTHVTWRWCFYINLPIGGLAIIMFLLTY 212

  Fly   245 RAER--ILQRNNNPAGQIPKLT---------------------DVFSFKPPFWMVSIICVAYYVA 286
            :||.  |||:..:..|.|...|                     |.|.|        .:|.|..|.
Yeast   213 KAENKGILQQIKDAIGTISSFTFSKFRHQVNFKRLMNGIIFKFDFFGF--------ALCSAGLVL 269

  Fly   287 IFPFIALGQNFFVDRFGLSPAEANTVDSLVYLIAAVSSPVFG-----FIIDKLG---RNVTWVFT 343
            ....:..|.|.:         ..|:...:.||:..|...:|.     |:.||..   .|:::...
Yeast   270 FLLGLTFGGNKY---------SWNSGQVITYLVLGVLLFIFSLVYDFFLFDKFNPEPDNISYRPL 325

  Fly   344 ATLTTIGAHALL-----TFTQLTPYVGMIIMGLSYSML--AASLWP----LVALIIPEYQLGTAY 397
            .....:...|::     ||...|.|.|.:|..:.:..|  |:|.|.    |:.::|.......|.
Yeast   326 LLRRLVAKPAIIIVNMVTFLLCTGYNGQMIYSVQFFQLIFASSAWKAGLHLIPIVITNVIAAIAS 390

  Fly   398 GFCQSIQNLGLAVITIVAGIIVDHSGGEHMWLQL----------------FFMGW-LTIALISTG 445
            |..  .:.|||....::.|.::...|...|.|..                |.:|: |..:|:|
Yeast   391 GVI--TKKLGLVKPLLIFGGVLGVIGAGLMTLMTNTSTKSTQIGVLLLPGFSLGFALQASLMS-- 451

  Fly   446 VIWAYNNKNRGNLNMT---PQQRAQFVSAENYQNF 477
                      ..|.:|   |:....|:....:..|
Yeast   452 ----------AQLQITKDRPEAAMDFIEVTAFNTF 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mrva	NP_001261505.1	MFS	55..448	CDD:119392	92/471 (20%)
mrva	NP_001261505.1	MFS_1	58..410	CDD:284993	83/413 (20%)
VBA5	NP_013031.3	MFS_Azr1_MDR_like	43..493	CDD:341045	99/513 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157341822
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930