DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mrva and mfsd1

DIOPT Version :9

Sequence 1:	NP_001261505.1	Gene:	mrva / 38808	FlyBaseID:	FBgn0035763	Length:	478	Species:	Drosophila melanogaster
Sequence 2:	XP_002933284.1	Gene:	mfsd1 / 779536	XenbaseID:	XB-GENE-1011077	Length:	512	Species:	Xenopus tropicalis

Alignment Length:	479	Identity:	236/479 - (49%)
Similarity:	335/479 - (69%)	Gaps:	25/479 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 EDEERIVDNEEVSRPTEEDQVVSRAGRRDNELSLPSGGCCMPSSTSHRFMALVFMCLLGFGSYFC 68
            :||:|            |..:...||.|..:::    ..|.||..:||.:.|..||.||||||||
Frog     3 DDEDR------------ETLLPGAAGSRKRDMA----AICDPSRFAHRVVVLALMCFLGFGSYFC 51

  Fly    69 YDAPGALQNYFKKDLNLTSAQFTLIYSIYSWPNVVLCFVGGFLIDRLFGIRLGTIIYMMILLVGQ 133
            ||.|.|||...:.|:.:.:|.|..:|:.||||||||||.|||||||:|||||||||:.:.:.|||
Frog    52 YDNPAALQTQVQADMKVNTADFMQLYAFYSWPNVVLCFFGGFLIDRVFGIRLGTIIFSLFVCVGQ 116

  Fly   134 LIFACGGILDAFWMMILGRFIFGIGAESLAVAQNSYAVLWFKGKELNMVFGLQLSVARFGSTVNF 198
            :|||.|.:::|||:|..||.:||||.||||||||:|||.||||||||:|||||||:||.|||||.
Frog   117 VIFATGALVNAFWLMEAGRLVFGIGGESLAVAQNTYAVSWFKGKELNLVFGLQLSMARVGSTVNM 181

  Fly   199 WVMQPIYEYVSNFY--KGHTALGVVLLLATLTCVMSMTCALILGWMDKRAERILQRNNNPAGQIP 261
            .||..:|..:.:..  .|::.|||.|::..:||:.|:.|||:||::|||||:||.:.....|::.
Frog   182 NVMGLVYSRIKDHMGAAGYSTLGVTLMIGAVTCIFSLICALVLGYLDKRAEKILDKEQGKTGEVI 246

  Fly   262 KLTDVFSFKPPFWMVSIICVAYYVAIFPFIALGQNFFVDRFGLSPAEANTVDSLVYLIAAVSSPV 326
            :||||..|....|::.||||.||||:||||.||:.||:::|..||.:|..::|:||:|:|..|||
Frog   247 QLTDVKDFSLSLWLIFIICVCYYVAVFPFIGLGKVFFIEKFQFSPLQAGAINSVVYIISAPLSPV 311

  Fly   327 FGFIIDKLGRNVTWVFTATLTTIGAHALLTFTQLTPYVGMIIMGLSYSMLAASLWPLVALIIPEY 391
            .||::|::|:|:.||..|.:||:.:|.:|.||...|::.|.::|:|||:||.:|||:||.::||:
Frog   312 LGFMVDRVGKNIIWVMCAVVTTLASHLMLAFTFWNPWIAMSLLGISYSLLACALWPMVAFVVPEH 376

  Fly   392 QLGTAYGFCQSIQNLGLAVITIVAGIIVDHSGGEHMWLQLFFMGWLTIALISTGVIWAYNNKNRG 456
            ||||||||.|||||||||:|.||||:|:|.||  :::|::||...|.:|:|:..:::..|....|
Frog   377 QLGTAYGFMQSIQNLGLAIIAIVAGVILDASG--YLFLEVFFSACLCMAIIAVVMLYFVNLLRGG 439

  Fly   457 NLNMTPQQRAQF-----VSAENYQ 475
            :||::..:|.:.     :.||..|
Frog   440 DLNLSAWEREKLQKQAAIEAEKEQ 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mrva	NP_001261505.1	MFS	55..448	CDD:119392	216/394 (55%)
mrva	NP_001261505.1	MFS_1	58..410	CDD:284993	199/353 (56%)
mfsd1	XP_002933284.1	MFS_MFSD1	38..433	CDD:340898	216/396 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	289	1.000	Domainoid score	I1533
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11228
Inparanoid	1	1.050	504	1.000	Inparanoid score	I1312
OMA	1	1.010	-	-		QHG53923
OrthoDB	1	1.010	-	-		D412964at33208
OrthoFinder	1	1.000	-	-		FOG0007323
OrthoInspector	1	1.000	-	-		otm48564
Panther	1	1.100	-	-	LDO	PTHR23512
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5598
SonicParanoid	1	1.000	-	-		X5435
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110