DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mrva and F27D9.2

DIOPT Version :9

Sequence 1:	NP_001261505.1	Gene:	mrva / 38808	FlyBaseID:	FBgn0035763	Length:	478	Species:	Drosophila melanogaster
Sequence 2:	NP_509296.1	Gene:	F27D9.2 / 181028	WormBaseID:	WBGene00017861	Length:	498	Species:	Caenorhabditis elegans

Alignment Length:	553	Identity:	106/553 - (19%)
Similarity:	200/553 - (36%)	Gaps:	150/553 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 EDEERIVDNEEVSR----------PTEEDQVVSRAGRRDNELSLPSGGCCMPSSTSHRFMALVFM 58
            |..|:|:|:..:.:          ||..|       :.|.:....:|.|....:|.
Worm     7 ETGEKILDDGSIGQSNFDQTEAMLPTPSD-------KTDWKSIYLAGSCAFIQATQ--------- 55

  Fly    59 CLLGFGSYFCYDAPGALQNYFKKDLNLTSAQFTLIYSIYSWPNVVLCFVGGFLIDRLFGIRLGTI 123
                |..:|....|..|    ..:.|:|...|.::.::||....:...|.||..:|:..:|...|
Worm    56 ----FAIFFTSMYPYIL----TLEHNVTQTSFGIVVAMYSVSQAIFSPVFGFWSNRIGQVRFPLI 112

  Fly   124 IYMMILLVGQLIFACGGILDA--FWMMILGRFIFGIGAESLAVAQNSYAVLWFKGKELNMVF--- 183
            :..:::..|.:.:.....|.:  .::|:|.|.|.|.|..::::.: :||......|:.:...
Worm   113 VGFIVMAFGNITYLSLQYLSSNHLYVMMLARLIAGGGTGNMSLLR-AYASTASTSKDRSRAIACV 176

  Fly   184 ------------GLQLSVARFGSTVNFWVMQPIYEYVSNFYKGHTALGVVLLLAT---LTC-VMS 232
                        ||||            :..|:.|      .|...||:.:.:.|   |.| :::
Worm   177 SGGIALGTMMGPGLQL------------LFSPLGE------NGINILGLNISIYTSPALFCLILN 223

  Fly   233 MTCALI--LGWMDK----RAERILQRNNNPAGQIPKLTDVFSFKPPFWMVSIICVAYYVAIF--- 288
            :|..||  |.:::|    ..:.|:|...|...:|.||.     .|.|..:.:..:..:..||
Worm   224 VTGLLIVKLAFVEKYIINHGKNIVQDEENGEKKIKKLA-----SPDFIAILLCIITRFSQIFLNT 283

  Fly   289 PFIALGQNFFVDRFGLSPAEANTVDSLVYLIAA------------------VSSPVFGFIIDKLG 335
            ...::|..:.:..|||...|:.::::.|:.:|.                  :.:.||.||  .|.
Worm   284 TIESIGSAYTMMMFGLEKEESVSINAGVHTVAGSIAAFMFICFIFTGVRRYMKNRVFTFI--SLS 346

  Fly   336 RNVTWVFT----------ATLTTIGAHA------------LLTFTQLTPYVGMI-IMGLSYSMLA 377
            ..:.|:..          ..|.|.|::|            |....:...|:|.| :.|:::|.:.
Worm   347 IPLVWLIATYPYKFYSDHVQLMTNGSNANCDTEKYSWCTDLTKVNEYVYYIGFIMVFGVAFSFMN 411

  Fly   378 ASLWPLVALIIPEYQLGTAYGFCQSIQNLGLAVITIVAGIIVDHSGGEHMWLQLFFMGWLTIALI 442
            .::..|.:.:|.....||..|..|...:.|..:..::...:....|....||.|...   .:.||
Worm   412 ITVTTLFSKVIGPRPQGTYQGVYQMAGSFGRMLAPLLMSYVYTLYGPSIPWLILIVN---LVVLI 473

  Fly   443 STGVIWAYNNKNRGNLNMTPQQRAQFVSAENYQ 475
            |..:|                .|.:.|..|.|:
Worm   474 SAWII----------------LRVRMVPFEKYE 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mrva	NP_001261505.1	MFS	55..448	CDD:119392	90/463 (19%)
mrva	NP_001261505.1	MFS_1	58..410	CDD:284993	83/422 (20%)
F27D9.2	NP_509296.1	MFS_MFSD8	42..484	CDD:340884	95/503 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156830
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930