DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mrva and mfsd1l

DIOPT Version :9

Sequence 1:	NP_001261505.1	Gene:	mrva / 38808	FlyBaseID:	FBgn0035763	Length:	478	Species:	Drosophila melanogaster
Sequence 2:	XP_002666794.5	Gene:	mfsd1l / 100003326	ZFINID:	ZDB-GENE-080917-43	Length:	482	Species:	Danio rerio

Alignment Length:	456	Identity:	149/456 - (32%)
Similarity:	228/456 - (50%)	Gaps:	55/456 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 HRFMALVFMCLLGFGSYFCYDAPGALQNYFK----------------------KDLNLTSAQFTL 92
            :||:.|.|.|:|.||||||:|.|..||..|:                      :.|.:|..::.|
Zfish    10 YRFVVLFFNCMLTFGSYFCFDIPSVLQEQFQGNLTCPNGTVSNSTGNGTGTCVEGLGMTPQEYNL 74

  Fly    93 IYSIYSWPNVVLCFVGGFLIDRLFGIRLGTIIYMMILLVGQLIFACG----GILDAFWMMILGRF 153
            :|:||:|.|.|:..:.|||||:| |.|.|..::..:.::|..|||.|    |......:|:.||.
Zfish    75 LYAIYAWTNAVVVIMAGFLIDKL-GNRFGVFLFSFLTVLGSAIFALGSHFKGTTYLLPLMLTGRL 138

  Fly   154 IFGIGAESLAVAQNSYAVLWFKGKELNMVFGLQLSVARFGSTVNFWVMQPIYEYVSNFYKGHTAL 218
            :||.|..||.:.||.....||:||||.:.|||.|:.:|.||.:||::.|   .:.|.:....|..
Zfish   139 LFGSGNGSLTIVQNRITAFWFRGKELALAFGLTLAFSRLGSVLNFFLTQ---RFESQYGMQWTLW 200

  Fly   219 GVVLLLATLTCVMSMTCALILGWMDKRAERILQRNNNPAGQIP------KLTDVFSFKPPFWMVS 277
            |     .||.||:....|:.:..:||...:.|..:    |.|.      ::.||......:|::.
Zfish   201 G-----GTLLCVLGFLSAVTVSVLDKMGMKQLGLD----GAIQEESRKVRVQDVKRLSLRYWLLV 256

  Fly   278 IICVAYYVAIFPFIALGQNFFVDRF-GLSPAEANTVDSLVYLIAAVSSPVFGFIIDKLG-RNVTW 340
            :..:.:|..||||||....|..|:: |.|..||..:...||..:.|.:...|.:||.:| |.|..
Zfish   257 LTIMFFYNGIFPFIADASTFIQDKYSGYSQKEAAYIAGAVYDSSLVLAAAVGILIDYVGLRGVFA 321

  Fly   341 VFTATLTTIGAHALLTFTQLTPYVGMIIMGLSYSMLAASLWPLVALIIPEYQLGTAYGFCQSIQN 405
            |..|.| |:....||.||.:.|.|..:.:|::||..|||:||.:.|::|:..||||.|...|||.
Zfish   322 VLCAVL-TLPVFGLLAFTFVPPLVSTVWLGITYSFAAASMWPSIPLVVPQATLGTAMGLATSIQM 385

  Fly   406 LGLAVITIVAGIIVDHSGGE---HMW---LQLFFMGWLTIALISTGVIWAYNNKNRGN-LNMTPQ 463
            :|:.:..:|.|.|:.....:   .:|   ..:.||...||:.|.|..|....:..:|: ||.|.:
Zfish   386 VGIGISNLVVGQILGTKSSDVKIPLWRWQYMMIFMLANTISCIVTSTILNIIDYRQGSTLNKTTK 450

  Fly   464 Q 464
            :
Zfish   451 R 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mrva	NP_001261505.1	MFS	55..448	CDD:119392	142/432 (33%)
mrva	NP_001261505.1	MFS_1	58..410	CDD:284993	130/385 (34%)
mfsd1l	XP_002666794.5	MFS_1	63..391	CDD:311564	117/341 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53923
OrthoDB	1	1.010	-	-		D412964at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101417
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.830